50820-65-0, Methyl 1H-indole-6-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
50820-65-0, To a DMF (60 mL) solution of methyl 1H-indole-6-carboxylate (5.1 g, 29.1 mmol) at -60 C was added a DMF solution (40 mL) of NBS (5.70 g, 32.0 mmol)dropwise. The reaction mixture was stirred for 2 hours while it was warmed up to room temperature. The reaction mixture was then poured into ice water (1 L) and the precipitate formed was collected through via vacuum filtration. The solid was washed with water. The solid was dissolved in ethyl acetate and washed twice with sat. aq. NaC1. The ethyl acetate layer was separated, dried (Na2504), filtered andconcentrated to give the cmde product. The material was carried on without further purification. LCMS (ESI) m/e 254.1 [(M+H), calcd C10H9Br1N1O2, 253.91; LC/MS retention time (method A): IR = 1.63 mm.
The synthetic route of 50820-65-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; LUO, Guanglin; CHEN, Ling; (83 pag.)WO2017/184658; (2017); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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