With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5416-80-8,2-Methyl-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.
INTERMEDIATE 9 – PREPARATION OF 3-(5-Chloro-1 H-indol-3-yl)propan-1-amine. To a solution of 3-(3-Azidopropyl)-5-chloro-1 H-indole (0.299 g; 1.27 mmol) in THF (9 mL) were added triphenylphosphine (0.354 g; 1.34 mmol) and water (0.6 mL). The reaction mixture was stirred at room temperature for 22 hours and was then concentrated under reduced pressure. The residue was dissolved in dichloromethane (10 mL) and 10 mL of 6N hydrochloric acid were added. After separation, the aqueous layer was further extracted with dichloromethane (2×10 mL) and the pH was adjusted to 14 with an aqueous solution of sodium hydroxide 6N. This basic solution was extracted dichloromethane (3×20 mL) and the combined organic layer was dried over magnesium sulphate, and evaporated to afford 0.089 g (34%) of 3-(5-Chloro-1 H-indol-3-yl)propan-1 -amine as a white solid.ESI/APCI(+): 209 (M+H); ESI/APCI(-): 207 (M-H).
5416-80-8, 5416-80-8 2-Methyl-1H-indole-3-carbaldehyde 73166, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D; REMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; MARCHAND, Arnaud; ALLASIA, Sara; KILONDA, Amuri; CHALTIN, Patrick; WO2012/80220; (2012); A1;,
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