With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7506-66-3,cis-Hexahydro-1H-isoindole-1,3(2H)-dione,as a common compound, the synthetic route is as follows.
7506-66-3, To the crude spiro quaternary ammonium hydroxide mixture (280g) was added Example 1 cis-dimethyl cyclohexane imide (84.8g) in MIBK (1272ml) suspension. Under vigorous stirring refluxing, the reaction system after water net, the reaction system temperature was lowered to 50 C-60 C, weighed DMAC (181 g) into the reaction mixture, continue to heat refluxing 7-10 hour. After completion of the reaction and the DMAC MIBK was distilled off, do not pay attention to the reaction system temperature above 135 C, above 135 C after distillation under reduced pressure to remove the DMAC and MIBK, in addition to the net after, the reaction liquid was boiled in boiling water 5- 10 minutes, filtered and cooled, this operation repeated 2-3 times to remove the reaction product mixture of inorganic salts. When, after the remaining material was added ethanol (400ml), at 20 C_40 C conditions, hydrogen chloride gas for 30 minutes to saturation, then refluxed for 30 minutes, concentrating the reaction solution, a large number of crystallization, cooling is cooled until crystallization , crude 175g. The precipitate was available in 95% ethanol was recrystallized as white needles after recrystallization of perospirone hydrochloride (134g). The total product yield was 69.95%, 99.85% purity liquid.
7506-66-3 cis-Hexahydro-1H-isoindole-1,3(2H)-dione 6992236, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Patent; Yantai Besten Pharmaceutical Co., Ltd.; Bi, Haidong; Zhang, Yifang; (8 pag.)CN105669665; (2016); A;,
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