With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.83515-06-4,5-Bromo-2-phenyl-1H-indole,as a common compound, the synthetic route is as follows.
83515-06-4, A stream of nitrogen under 2-nitrophenylboronic acid (11.04 g, 66.14 mmol) and the preparation example 18 of In the obtained 5-bromo-2-phenyl-1H-indole (15 g, 55.12 mmol), NaOH (6.61 g, a mixture of 165.36 mmol) and THF / H2O (200 ml / 100 ml), and then insert the Pd (PPh3) 4 (3.18 g, 5 mol) in 40 , was stirred for 12 hours at 80 .After completion of the reaction, extracted with methylene chloride, and then filtered into a MgSO4. After removal of the solvent in the resulting organic layerColumn chromatography (Hexane: EA = 5: 1 (v / v)) to give 5- (2-nitrophenyl) -2-phenyl-1H-indole to obtain a (10.74 g, yield 62%). 1H-NMR: delta 6.88 (dd, 1H), 7.21 (d, 1H), 7.32 (m, 1H), 7.34 (d, 1H), 7.46 (m, 3H), [0382] 7.64 (m, 2H), 7.77(d, 2H), 8.02 (d, 2H), 11.73 (s, 1H).
83515-06-4 5-Bromo-2-phenyl-1H-indole 838923, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; Doosan Co. Ltd.; Lee, Young Hwan; Kim, Tae Hyoung; Son, Hyo? Seok; Bae, Hyeong Chan; Park, Ho Cheol; Lee, Chang Jun; Shin, Jin Young; Baek, Young Mi; (97 pag.)KR101571589; (2015); B1;,
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