885518-25-2, 6-Fluoro-1H-indol-4-amine is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,885518-25-2
To a solution of intermediate 12 (233.00 mg, 0.61 mmol), intermediate 34c (100.00 mg,0.67 mmol), Pd(OAc)2 (137.00 mg, 0.061 mmol) and Cs2CO3 (592.00 mg, 1.82 mmol) in1,4-dioxane (5 mL) was added BNAP (38.00 mg, 0.06 1 mmol) and the reaction mixturewas heated for 3 h at 95 C. The reaction mixture was then diluted with ethyl acetate and washed with water and brine. The organic layer was dried with sodium sulfate and concentrated in vacuo to give 397 mg of intermediate 35c (quant. yield, 76% purity based on LC/MS, dark black foam) which was used in the next step without any further purification.
The synthetic route of 885518-25-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; JANSSEN PHARMACEUTICA NV; STANSFIELD, Ian; QUEROLLE, Olivier, Alexis, Georges; LIGNY, Yannick, Aime, Eddy; GROSS, Gerhard, Max; JACOBY, Edgar; MEERPOEL, Lieven; GREEN, Simon, Richard; HYND, George; KULAGOWSKI, Janusz, Jozef; MACLEOD, Calum; MANN, Samuel, Edward; (419 pag.)WO2018/2219; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles