The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane(SMILESS: C1(CC2=N[C@@H](C3=CC=CC=C3)CO2)=N[C@@H](C4=CC=CC=C4)CO1,cas:132098-59-0) is researched.Quality Control of Tris(3,5-bis(trifluoromethyl)phenyl)phosphine. The article 《Catalytic activity of copper-bis(oxazoline) grafted on mesoporous silica in enantioselective cyclopropanation》 in relation to this compound, is published in Reaction Kinetics, Mechanisms and Catalysis. Let’s take a look at the latest research on this compound (cas:132098-59-0).
Chiral Ph substituted bis(oxazoline) (PhBox) was covalently immobilized through carbamate linkers onto mesoporous silica materials. These supports were previously prepared by the sol-gel method and they exhibited different textural properties. The presence and the integrity of the bis(oxazoline) ligand was checked by 13C-CP-MAS-NMR. These chiral mesoporous materials were complexed with copper(II) triflate. In spite of the different textural properties of these supports, the copper loading, determined by ICP-AES, was nearly the same (0.041-0.044 mmol Cu/g of solid). The supported Cu(II) complexes were tested as catalysts in the enantioselective cyclopropanation of styrene with Et diazoacetate. Enantioselectivities were consistently lower than those obtained in homogeneous phase. Different analyses point to a difficulty in the formation of the expected chelate, due to the presence of a coordinating functional group in the linker, as responsible for the loss in enantioselectivity. The textural properties of the materials significantly affected the behavior upon recovery.
As far as I know, this compound(132098-59-0)Quality Control of Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles