An article Accessing New 5-alpha-(3,3-Disubstituted Oxindole)-Benzylamine Derivatives from Isatin: Stereoselective Organocatalytic Three Component Petasis Reaction WOS:000544049200011 published article about ORGANOBORONIC ACIDS; MULTICOMPONENT REACTIONS; ARYLBORONIC ACIDS; BORONIC ESTERS; AMINES; SALICYLALDEHYDES; CYCLIZATION; INHIBITORS; DISCOVERY; ALDEHYDES in [Marques, Carolina S.; Burke, Anthony J.] Univ Evora, Inst Res & Adv Studies, Rua Romao Ramalho 59, P-7000671 Evora, Portugal; [McArdle, Patrick; Erxleben, Andrea] Natl Univ Ireland, Sch Chem, Galway, Ireland; [Burke, Anthony J.] Univ Evora, Dept Chem, Sch Sci & Technol, Rua Romao Ramalho 59, P-7000671 Evora, Portugal in 2020.0, Cited 67.0. SDS of cas: 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4
A one-step, three-component Petasis reaction of isatin derived 5-arylboronate-3-substituted oxindole derivatives with salicylaldehydes and secondary amines affords new enantiomerically pure structurally diverse 5-alpha-(3-substituted-oxindole)-benzylamine derivatives. The reaction shows good substrate and reagent scope affording the products with good to excellent yields (up to >99 % yield) and enantioselectivities (up to 99 % ee) using cheap and readily available (R)-BINOL as the organocatalyst. A diastereoselective version of the reaction was also developed where moderate yields (37 to 55 % yield), excellent enantioselectivities (up to 99 % ee) and good diastereoselectivities (up to 86 % de) were obtained for new 5-alpha-(3-hydroxy-oxindole)-benzylamine derivatives, having two stereocenters. The reaction is also feasible on gram-scale.
About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Marques, CS; McArdle, P; Erxleben, A; Burke, AJ or concate me.. SDS of cas: 100-83-4
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles