Recently I am researching about DECARBOXYLATIVE COUPLING REACTIONS; DECARBONYLATIVE DIRECT OLEFINATION; C3-SELECTIVE DIRECT ALKYLATION; CINNAMIC-ACIDS; OXIDATIVE OLEFINATION; REGIOSELECTIVE SYNTHESIS; DIRECT ARYLATION; BOND ACTIVATION; DIRECTING GROUP; OXIME ESTERS, Saw an article supported by the Program for China Scholarship CouncilChina Scholarship Council [201806360122]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21372258]; Beijing National Laboratory for Molecular Sciences [BNLMS201845]; US National Science FoundationNational Science Foundation (NSF) [CHE-1902509]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Zhao, HQ; Xu, X; Luo, ZL; Cao, L; Li, BH; Li, HR; Xu, LJ; Fan, QH; Walsh, PJ. The CAS is 80-59-1. Through research, I have a further understanding and discovery of (E)-2-Methylbut-2-enoic acid. COA of Formula: C5H8O2
A versatile Rh(i)-catalyzed C6-selective decarbonylative C-H alkenylation of 2-pyridones with readily available, and inexpensive alkenyl carboxylic acids has been developed. This directed dehydrogenative cross-coupling reaction affords 6-alkenylated 2-pyridones that would otherwise be difficult to access using conventional C-H functionalization protocols. The reaction occurs with high efficiency and is tolerant of a broad range of functional groups. A wide scope of alkenyl carboxylic acids, including challenging conjugated polyene carboxylic acids, are amenable to this transformation and no addition of external oxidant is required. Mechanistic studies revealed that (1) Boc(2)O acts as the activator for the in situ transformation of the carboxylic acids into anhydrides before oxidative addition by the Rh catalyst, (2) a decarbonylation step is involved in the catalytic cycle, and (3) the C-H bond cleavage is likely the turnover-limiting step.
About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Zhao, HQ; Xu, X; Luo, ZL; Cao, L; Li, BH; Li, HR; Xu, LJ; Fan, QH; Walsh, PJ or concate me.. COA of Formula: C5H8O2
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles