Song, Yuntao et al. published their patent in 2017 |CAS: 860624-88-0

The Article related to anilino heteroaryl pyrimidine compound preparation egfr kinase inhibitor cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 860624-88-0

On July 13, 2017, Song, Yuntao; Brdiges, Alexander James published a patent.SDS of cas: 860624-88-0 The title of the patent was Preparation of 2-anilino-4-heteroaryl pyrimidine compounds as selective EGFR tyrosine kinase inhibitors for treatment of cancer. And the patent contained the following:

The present invention provides compounds of formula I or a subgeneric structure or species thereof, or a pharmaceutically acceptable salt, ester, solvate, and/or prodrug thereof, and methods and compositions for treating or ameliorating abnormal cell proliferative disorders, such as cancer,. Compounds of formula I [wherein A is (un)substituted indol-1-yl, (un)substituted indol-3-yl, (un)substituted indazol-3-yl, etc.; R1 = H, F, Cl, OH, etc.; R2 = -OCF3, cyclopropyl, methoxy, etc.; R3 = C2-6 alkenyl-R7, C2-6alkynyl-R7, R7, etc; R7 = OH, C1-6alkoxy, oxetanyl, pyrrolidinyl, etc.; R10 = H, -CD3, C1-6alkyl, etc.; E1 and E2 independently = C-R1 or N with the proviso that E1 and E2 are not both N; E3 and Z are independently CH or N; Y = -C(O)-CHCH-aryl, -C(O)-CHCH-heteroaryl, -S(O)2-CHCH-aryl, etc.] or a stereoisomer or a pharmaceutically acceptable salt, solvate, ester, or prodrug thereof, are claimed and exemplified. Example compound II was prepared from a multistep procedure (preparation given). Candidate compounds of I were evaluated for inhibition of proliferation of PC-9 cells from which II demonstrated an IC50 value of 6.8 nM. The experimental process involved the reaction of Methyl 5-bromoindoline-7-carboxylate(cas: 860624-88-0).SDS of cas: 860624-88-0

The Article related to anilino heteroaryl pyrimidine compound preparation egfr kinase inhibitor cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 860624-88-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles