On June 3, 2010, Staehle, Wolfgang; Kober, Ingo; Schiemann, Kai; Schultz, Melanie; Wienke, Dirk published a patent.Category: indole-building-block The title of the patent was Preparation of benzo[b][1,6]naphthyridines as inhibitors of autotaxin for the treatment of tumors. And the patent contained the following:
Title compounds I [D = D'[R1]m; D’ = Ar, Het1; Het1 = heterocycle with provisos; R1 = H, halo, OH, etc.; R4 = [R4′]p; R4′ = H, halo, OH, etc.; m = 0-5; p = 1-4; R2, R3 = alkyl with provisos; R5 = H, halo, OH, etc.; X, Y = CH2, (CH2)2, CO, etc.; Z = O, NH, CH=CH, etc.] and their pharmaceutically acceptable salts and formulations were prepared Benzo[b][1,6]naphthyridine II is an example from the disclosed process. Title compounds I exhibited inhibition activity in autotaxin assays. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Category: indole-building-block
The Article related to benzonaphthyridine preparation autotaxin inhibition antitumor agent, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Category: indole-building-block
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles