Synthesis of 5-methoxy-2, 3-dimethyl-1H-indole was written by Sun, Ming-na;Zhou, Yi;Zhang, Pei-quan;Wang, Sheng;Sun, Ming-jiao. And the article was included in Huaxue Shiji in 2019.Reference of 1076-74-0 This article mentions the following:
The title compound was synthesized from 5-methoxy-2-methyl-1H-indole by a Vilsmeier-Haack reaction and a reduction reaction. 5-Methoxy-2-methyl-1H-indole was firstly converted to 5-methoxy-2-methyl-1H-indole-3-carboxaldehyde via a Vilsmeier-Haack reaction. The latter intermediate was subjected to sodium cyanoborohydride and acetic acid in THF to synthesize the target compound, which was confirmed by 1HNMR, 13CNMR and MS. This method has considerable advantages in terms of the use of easily available raw material, simple operation, mild reaction conditions and high yield. The title compound is an important organic intermediate, and is widely used in the field of medicine. In the experiment, the researchers used many compounds, for example, 5-Methoxy-2-methyl-1H-indole (cas: 1076-74-0Reference of 1076-74-0).
5-Methoxy-2-methyl-1H-indole (cas: 1076-74-0) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Reference of 1076-74-0
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles