On April 30, 2006, Sun, Suya; Jia, Youzhi; Zeng, Ning; Li, Famei published an article.Electric Literature of 79815-20-6 The title of the article was Chiral ligand-exchange chromatography for separation of three stereoisomers of octahydroindole-2-carboxylic acid. And the article contained the following:
A novel HPLC method is described for separation of the three stereoisomers of octahydroindole-2-carboxylic acid (Oic), an intermediate in the synthesis of perindopril. The chiral mobile phase contained the complex of Cu(II) with the optically active selector L-phenylalaninamide (L-PheA), and an ion-pair reagent, sodium 1-octanesulfonate. The effects of the concentrations of the Cu(II)-L-PheA complex and the ion-pair reagent, mobile phase pH, ionic strength, acetonitrile content, and column temperature were studied. Satisfactory resolution was achieved for three stereoisomers, RRR-, SSS-, and SRR-Oic. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Electric Literature of 79815-20-6
The Article related to octahydroindolecarboxylic acid stereoisomer chiral ligand exchange chromatog, Organic Analytical Chemistry: Separations and other aspects.Electric Literature of 79815-20-6
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles