On January 3, 2013, Suzuki, Masaki; Kondo, Kazumi; Kurimura, Muneaki; Valluru, Krishna Reddy; Takahashi, Akira; Kuroda, Takeshi; Takahashi, Haruka; Fukushima, Tae; Miyamura, Shin; Ghosh, Indranath; Dogra, Abhishek; Harriman, Geraldine; Elder, Amy; Shimizu, Satoshi; Hodgetts, Kevin J.; Newcom, Jason S. published a patent.Recommanded Product: 6-Chloro-2,3-dihydro-1H-indole The title of the patent was Quinazolines as STEP inhibitors and their preparation and use in the treatment of central nervous system agents. And the patent contained the following:
Methods of treating disorders using quinazoline compounds of formula I that modulate STriatal-enriched tyrosine phosphatase (STEP) are described herein. Compounds of formula I wherein m is 0 and 1; L is a bond and NH and derivatives; R1 is H, C1-8 alkyl, halo, C1-8 haloalkyl, etc.; R2 is C1-8 alkoxy, benzodioxolyl, piperazinyl, halo, etc.; R3 is pyridinyl, pyrimidinyl, pyrazinyl, etc.; R4 is H, C1-8 alkyl, C1-8 alkoxy, etc.; and salts thereof, are claimed. Example compound II•3HCl was prepared by amination of 4-bromo-6-methoxy-2-(pyridin-3-yl)quinazoline with 3-aminopyridine-2-carboxamide. All the invention compounds were evaluated for their STEP inhibitory activity (some data given). The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Recommanded Product: 6-Chloro-2,3-dihydro-1H-indole
The Article related to quinazoline preparation step inhibitor treatment cns disorder, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 6-Chloro-2,3-dihydro-1H-indole
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles