Swaminathan, S. published the artcileSynthesis of ethyl 1-acetyl-2-(3-indolylmethyl)carbazate. An analog of Nα-acetyltryptophan ethyl ester, Recommanded Product: 2-Ethoxy-1H-indole, the main research area is .
Indole-3-carboxaldehyde (5 g.) in 100 ml. EtOH was added to a solution of 2.69 g. NH2NHAc in 10 ml. H2O containing 1 drop HOAc, and the mixture refluxed 2 hrs. to yield 4.5 g. 3-indolealdehyde acetohydrazone (I), m. 253-5° (EtOH). I (1 g.) in 150 ml. EtOH was hydrogenated 2.5 hrs. at 50 psi over Pd-BaCO3 to yield 0.75 g. 1-acetyl-2-(3-indolylmethyl)hydrazine (II), m. 147.5-8.5° (EtOAc-petr. ether). Et3N (1 g.) in 10 ml. C6H6 was added to a solution of 1 g. II in 100 ml. C6H6, followed by dropwise addition during 30 min. of a solution of 0.6 g. ClCO2Et in 29 ml. C6H6, and the mixture stirred 3 hrs., kept overnight, and worked up to yield 1.1 g. Et 1-acetyl-2-(3-indolylmethyl)carbazate (III), m. 91-2° (C6H6). III was of interest as a potential tryptophan antagonist. A mixture of 0.5 g. II in 20 ml. 40% alc. NaOH was refluxed 6 hrs., EtOH removed in vacuo, and the residue diluted with H2O to yield 0.275 g. 3-indolealdazine (IV), m.p. and mixed m.p. 310-12°. IV (0.5 g.) was also obtained by refluxing 1 g. I with 40 ml. 20% alc. NaOH. A mixture of 1.5 g. indole-3-aldehyde, 0.5 g. 98-100% N2H4.H2O, 10 ml. EtOH, and a drop HOAc was refluxed 1 hr. and cooled to yield 1.2 g. IV, m. 310-12° (Me2CO).
Indian Journal of Chemistry published new progress in CAplus about 1009-27-4, 1009-27-4 belongs to class indole-building-block, name is 2-Ethoxy-1H-indole, and the molecular formula is C10H11NO, Recommanded Product: 2-Ethoxy-1H-indole.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles