Tag: 100-200

Synthesis and activity of novel 1-halogenobenzylindole linked triazole derivatives as antifungal agents was written by Na, Young Min. And the article was included in Bulletin of the Korean Chemical Society in 2011.SDS of cas: 827-01-0 This article mentions the following:

A series of 33 substituted indole-conazole compounds with piperizinyl and difluorophenyl moieties and 2 chiral centers, e. g. I, were prepared and tested for antifungal activity. Several products showed significant activity with both I and II exceeded the clin. prevalent antifungal drug fluconazole against C. albicans including a drug resistant strain. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0SDS of cas: 827-01-0).

5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.SDS of cas: 827-01-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Cobalt-Catalyzed Intramolecular Olefin Hydroarylation Leading to Dihydropyrroloindoles and Tetrahydropyridoindoles was written by Ding, Zhenhua;Yoshikai, Naohiko. And the article was included in Angewandte Chemie, International Edition in 2013.Name: 5-Chloroindole-3-carboxaldehyde This article mentions the following:

The authors developed an intramol. olefin hydroarylation reaction using a cobalt nitrogen-heterocyclic carbene (NHC) as a catalyst. The title compounds thus formed included dihydropyrroloindole derivatives and tetrahydropyridoindole derivatives The synthesis of the target compounds was achieved by a directed carbon-hydrogen bond (C-H bond) activation. Cobalt bromide (CoBr₂), 4,5-dihydro-1,3-bis(2,4,6-trimethylphenyl)-1H-imidazolium chloride (SImes chloride) was used as catalyst combination and [(Trimethylsilyl)methyl]magnesium chloride (Grignard reagent) was used as additive. A cyclization of N-[[1-(3-butenyl)-1H-indol-3-yl]methylene]-4-methoxybenzenamine (I) (indole alkene imine Schiff base) gave a pyrrolo[1,2-a]indolecarboxaldehyde derivative (II) and 6,7,8,9-tetrahydropyrido[1,2-a]indole-10-carboxaldehyde (III). In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Name: 5-Chloroindole-3-carboxaldehyde).

5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Name: 5-Chloroindole-3-carboxaldehyde

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Palladium-catalyzed oxidative cycloaddition through C-H/N-H activation: access to benzazepines was written by Wang, Lei;Huang, Jiayao;Peng, Shiyong;Liu, Hui;Jiang, Xuefeng;Wang, Jian. And the article was included in Angewandte Chemie, International Edition in 2013.Recommanded Product: 5-Isopropylindoline-2,3-dione This article mentions the following:

A synthesis of benzazepine heterocycles from isatins and alkynes via direct Pd-catalyzed oxidative cycloaddition is developed. Heterocycles are well tolerated in the reaction, which allows access to a number of unique mol. structures. The significance of the benzazepine scaffold as a structural element should render this method attractive for both synthetic and medicinal chem. In the experiment, the researchers used many compounds, for example, 5-Isopropylindoline-2,3-dione (cas: 150560-58-0Recommanded Product: 5-Isopropylindoline-2,3-dione).

5-Isopropylindoline-2,3-dione (cas: 150560-58-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Recommanded Product: 5-Isopropylindoline-2,3-dione

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Visible-Light-Mediated Cyclopropanation Reactions of 3-Diazooxindoles with Arenes was written by Zhao, Shuai;Chen, Xiang-Xiang;Gao, Nan;Qian, Mingcheng;Chen, Xin. And the article was included in Journal of Organic Chemistry in 2021.Reference of 112656-95-8 This article mentions the following:

The cyclopropanation reaction of 3-diazooxindoles with arenes was first accomplished using visible-light irradiation A series of spiro[norcaradiene-7,3′-indolin]-2′-ones, e.g., I, were synthesized for the first time in high yields and with excellent diastereoselectivities. The synthetic usefulness of this catalyst-free photochem. methodol. is illustrated by the further controllable rearrangement and epoxidation reactions. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Reference of 112656-95-8).

7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Reference of 112656-95-8

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Remote Control of Axial Chirality: Synthesis of Spirooxindole-Urazoles via Desymmetrization of ATAD was written by Zhang, Lin-Lin;Zhang, Ji-Wei;Xiang, Shao-Hua;Guo, Zhen;Tan, Bin. And the article was included in Organic Letters in 2018.Category: indole-building-block This article mentions the following:

In the presence of a nonracemic bisthiourea, 3-vinylindoles and N-Boc alkylideneoxindoles underwent diastereoselective and enantioselective tandem Diels-Alder and ene reactions and desymmetrization with triazolinediones in hexane to yield spirooxindolecarbazolylurazoles such as I containing axial chirality in 49-84% yields, 3:1-10:1 dr at the atropisomeric axes, and in 93->99% ee. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Category: indole-building-block).

5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Eosin Y-catalyzed one-pot synthesis of spiro[4H-pyran-oxindole] under visible light irradiation was written by Chen, Meng-Nan;Di, Jia-Qi;Li, Jiao-Mian;Mo, Li-Ping;Zhang, Zhan-Hui. And the article was included in Tetrahedron in 2020.Related Products of 774-47-0 This article mentions the following:

An efficient and simple synthetic approach was developed for the preparation of biol. interesting spiro[oxindole-3,4′-(4’H-pyran)] derivatives via visible light-mediated one-pot, three-component reaction of isatins, 1,3-dicarbonyl compounds and malononitrile by using an inexpensive organic dye, Na₂ eosin Y, as the photocatalyst in aqueous Et lactate at ambient temperature The substrate scope of this three-component reaction was expanded to linear 1,3-dicarbonyl compounds as viable starting materials. In the experiment, the researchers used many compounds, for example, 5,6-Difluoroindoline-2,3-dione (cas: 774-47-0Related Products of 774-47-0).

5,6-Difluoroindoline-2,3-dione (cas: 774-47-0) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Related Products of 774-47-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Rhodium(III)-catalyzed regioselective C2-amidation of indoles with N-(2,4,6-trichlorobenzoyloxy)amides and its synthetic application to the development of a novel potential PPAR缂?modulator was written by Shi, Jingjing;Zhao, Guanguan;Wang, Xiaowei;Xu, H. Eric;Yi, Wei. And the article was included in Organic & Biomolecular Chemistry in 2014.Synthetic Route of C8H6N2O2 This article mentions the following:

A new and efficient method for the direct regioselective C2-amidation of various functionalized indoles with several N-(2,4,6-trichlorobenzoyloxy)amides via Rh(III)-catalyzed C-H activation/N-O cleavage/C-N formation using the pyrimidyl group as a readily installable and removable directing group has been developed. With this method, a variety of valuable 2-amido indoles can be easily prepared under mild conditions with broad functional group tolerance and excellent region-/site-specificities. The results from biol. evaluation showed that compound I had a partial PPAR缂?agonistic activity and a strong PPAR缂?binding affinity with an IC₅₀ value of 120.0 nM, along with a less pronounced adipocyte differentiation ability compared to the currently marketed anti-diabetic drug rosiglitazone, suggesting that further development of such a compound might be of great interest. In the experiment, the researchers used many compounds, for example, 6-Nitro-1H-indole (cas: 4769-96-4Synthetic Route of C8H6N2O2).

6-Nitro-1H-indole (cas: 4769-96-4) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Synthetic Route of C8H6N2O2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Bi(OTf)₃ Enabled C-F Bond Cleavage in HFIP: Electrophilic Aromatic Formylation with Difluoro(phenylsulfanyl)methane was written by Betterley, Nolan M.;Kerdphon, Sutthichat;Chaturonrutsamee, Suppisak;Kongsriprapan, Sopanat;Surawatanawong, Panida;Soorukram, Darunee;Pohmakotr, Manat;Andersson, Pher G.;Reutrakul, Vichai;Kuhakarn, Chutima. And the article was included in Asian Journal of Organic Chemistry in 2018.Quality Control of 5-Chloroindole-3-carboxaldehyde This article mentions the following:

Bismuth(III) trifluoromethanesulfonate [Bi(OTf)₃] mediated mild electrophilic aromatic formylation utilizing difluoro(phenylsulfanyl)methane (PhSCF₂H) as a formylating agent in hexafluoro-2-propanol (HFIP) as a recyclable ionizing solvent has been developed. The active formylating species was generated via C-F bond cleavage and was characterized to be a bis(phenylsulfanyl)methyl cation by exptl. and computational ¹H and ¹³C NMR. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Quality Control of 5-Chloroindole-3-carboxaldehyde).

5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Quality Control of 5-Chloroindole-3-carboxaldehyde

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthesis, characterization and molecular docking studies of new indol(1H-3-yl)pyrimidine derivatives: Insights into their role in DNA interaction was written by Bhat, Radhika;Begum, Noor Shahina. And the article was included in Nucleosides, Nucleotides & Nucleic Acids in 2021.Recommanded Product: 827-01-0 This article mentions the following:

This study reports the synthesis of new indol(1H-3-yl) pyrimidine derivatives using various substituted indole-3-carbaldehydes, urea and malononitrile in the presence of ammonium chloride. The resulting compounds were characterized using anal. and spectroscopic methods. The mol. docking study exhibits that among the synthesized compounds, have great binding ability toward B-DNA. The binding efficiencies of compounds with CT-DNA were evaluated via UV-visible absorption spectral and viscosity studies. The findings establish that the compounds firmly bind through an intercalative mode to CT-DNA and provide a unique pattern of DNA binding. The photo-induced cleavage indicates that the compounds have UV-visible photo nuclease properties toward plasmid DNA as revealed by agarose gel electrophoresis approach. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Recommanded Product: 827-01-0).

5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Recommanded Product: 827-01-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Studies on the interactions of 5-R-3-(2-pyridyl)-1,2,4-triazines with arynes: inverse demand aza-Diels-Alder reaction versus aryne-mediated domino process was written by Kopchuk, Dmitry S.;Nikonov, Igor L.;Khasanov, Albert F.;Giri, Kousik;Santra, Sougata;Kovalev, Igor S.;Nosova, Emiliya V.;Gundala, Sravya;Venkatapuram, Padmavathi;Zyryanov, Grigory V.;Majee, Adinath;Chupakhin, Oleg N.. And the article was included in Organic & Biomolecular Chemistry in 2018.COA of Formula: C8H3F2NO2 This article mentions the following:

The interactions between substituted 5-substituted-3-(2-pyridyl)-1,2,4-triazines I [R¹ = H, Ph, indol-3-yl, etc. ; R² = Ph, 4-BrC₆H₄, 4-O₂NC₆H₄, etc.] with in-situ generated substituted aryne intermediates were studied. The reaction afforded either inverse demand (ID) aza-Diels-Alder products or 1,2,4-triazine ring rearrangement (domino) products as major ones depending on the nature of both the substituents at the C5 position of the 1,2,4-triazine core or in the aryne moiety. The structures of the key products were confirmed based on X-ray data. Based on the d. functional theor. (DFT) studies of the Diels-Alder transition state geometries, the influence of the nature of arynes on the direction of the 1,2,4-triazine transformation were proposed. In the experiment, the researchers used many compounds, for example, 5,6-Difluoroindoline-2,3-dione (cas: 774-47-0COA of Formula: C8H3F2NO2).

5,6-Difluoroindoline-2,3-dione (cas: 774-47-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.COA of Formula: C8H3F2NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles