Tag: 100-200

《Biphasic chemotaxis of Escherichia coli to the microbiota metabolite indole》 was written by Yang, Jingyun; Chawla, Ravi; Rhee, Kathy Y.; Gupta, Rachit; Manson, Michael D.; Jayaraman, Arul; Lele, Pushkar P.. Application of 120-72-9 And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2020. The article conveys some information:

Bacterial chemotaxis to prominent microbiota metabolites such as indole is important in the formation of microbial communities in the gastrointestinal (GI) tract. However, the basis of chemotaxis to indole is poorly understood. Here, we exposed Escherichia coli to a range of indole concentrations and measured the dynamic responses of individual flagellar motors to determine the chemotaxis response. Below 1 mM indole, a repellent-only response was observed At 1 mM indole and higher, a time-dependent inversion from a repellent to an attractant response was observed The repellent and attractant responses were mediated by the Tsr and Tar chemoreceptors, resp. Also, the flagellar motor itself mediated a repellent response independent of the receptors. Chemotaxis assays revealed that receptor-mediated adaptation to indole caused a bipartite response-wild-type cells were attracted to regions of high indole concentration if they had previously adapted to indole but were otherwise repelled. We propose that indole spatially segregates cells based on their state of adaptation to repel invaders while recruiting beneficial resident bacteria to growing microbial communities within the GI tract. The results came from multiple reactions, including the reaction of 1H-Indole(cas: 120-72-9Application of 120-72-9)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application of 120-72-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2016,International Journal of Pharmaceutical Sciences Review and Research included an article by Sekhar, Abinitha S.; Saranya, T. S.; Baskar, Vaishnav; Manakadan, Asha Ashokan. Application of 162100-42-7. The article was titled 《In silico approach of apoptosis induing ability of different indole derivatives by interaction with caspase9》. The information in the text is summarized as follows:

Indole compounds are well known for their wide variety of pharmacol. activities. It is the combination of benzene with pyrrole ring. Compounds having indole group are biol. important. They are used as antimicrobial, antiviral, antitubercular, antiinflammatory, anticancer, ant-diabetic and anticonvulsant agents. Because of the wide variety of biol. application, several substituted indole derivatives are studied for their mol. structure, mol. docking and bioavailability. The purpose of the study is to carry out the docking studies of indole derivatives containing electrophilic substitution and nucleophilic substitution with the anticancer target casp9. Fifty compounds were designed and by using Argus lab version 4.0.1. Their docking score was calculated and compared with the standard drug casodex. The drug likeness of compounds was performed using Lipinski rule of five. Result showed that 1,1′-(1H-indole-5,6-diyl)diethanone and 5-(trichloromethyl)-1H-indole and the phytoconstituent curcumin showed better docking score than that of the standard drug casodex. It is concluded that certain indole derivatives show greater affinity with casp9 protein. These compounds may be helpful in studying anticancer targets for casp9 protein. In the part of experimental materials, we found many familiar compounds, such as 6-Chloro-5-methyl-1H-indole(cas: 162100-42-7Application of 162100-42-7)

6-Chloro-5-methyl-1H-indole(cas: 162100-42-7) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application of 162100-42-7

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Yildiz, Halit; Tokalioglu, Serife; Soykan, Cengiz published an article in 2021. The article was titled 《Preparation of polyacrylonitrile/polyindole conducting polymer composite and its use for solid phase extraction of copper in a certified reference material》, and you may find the article in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy.Application In Synthesis of 1H-Indole The information in the text is summarized as follows:

A polyacrylonitrile/polyindole (PAN/PIN) [50, 50] conducting polymer composite was chem. synthesized using FeCl3 as an oxidizing agent in chloroform solution and nitrogen atm. at 10°C. The formation of the composite was supported by Fourier transform IR spectroscopy. The morphol. properties of the composite were investigated by at. force microscopy and SEM. The thermal properties of the composite were examined by using thermogravimetric analyses. It was found that the composite had good thermal stability. The conducting polymer composite was used for the first time as an adsorbent for solid phase extraction of Cu (II). The optimum pH was found to be 7. The adsorption and elution shaking times were 5 and 15 min, resp. The elution was done with 5 mL of 2 mol L-1 HNO3. The accuracy of the developed method was confirmed by analyzing certified reference material (TMDA-70.2 Lake Water). In the experiment, the researchers used 1H-Indole(cas: 120-72-9Application In Synthesis of 1H-Indole)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application In Synthesis of 1H-Indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 1H-IndoleIn 2019 ,《An insight into the medicinal perspective of synthetic analogs of indole: A review》 appeared in European Journal of Medicinal Chemistry. The author of the article were Thanikachalam, Punniyakoti Veeraveedu; Maurya, Rahul Kumar; Garg, Vishali; Monga, Vikramdeep. The article conveys some information:

A review. Heterocycles occupy a salient place in chem. due to their wide range of activity in the fields of drug design, photochem., agrochems., dyes, and so on. Amongst all, indole scaffold is considered as one of the most promising heterocycles found in natural and synthetic sources and has been shown to possess various biol. activity, including anti-inflammatory, anti-HIV, antitubercular, antimalarial, anticonvulsant, antidiabetic, antihypertensive, analgesics, antidepressant, anticancer, antioxidant, antifungal, and antimicrobial, etc. All the reported indole mols. bind to multiple receptors with high affinity, thus expedite the research on the development of novel biol. active compounds through the various approach. In this review, we aimed to highlight synthetic and medicinal perspective on the development of indole-based analogs. In addition, structural activity relationship (SAR) study to correlate for their biol. activity also discussed. In the experiment, the researchers used many compounds, for example, 1H-Indole(cas: 120-72-9Quality Control of 1H-Indole)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Quality Control of 1H-Indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Cu2O-incorporated MAF-6-derived highly porous carbons for the adsorptive denitrogenation of liquid fuel》 was published in Chemical Engineering Journal (Amsterdam, Netherlands) in 2020. These research results belong to Khan, Nazmul Abedin; Shin, Subin; Hwa Jhung, Sung. Formula: C8H7N The article mentions the following:

Metal-organic framework (MOF)-derived carbons (MDCs) with remarkable porosity were synthesized through pyrolysis of a MOF (metal-azolate framework-6 or MAF-6) in the presence of KOH activating agent. Further, Cu2O particles were synthesized under a mild condition within the MDCs. The Cu2O/MDCs showed very efficient adsorptions of both quinoline (454 mg/g) and indole (435 mg/g) from liquid fuel. Or, the Cu2O/MDC resulted in increase of quinoline and indole adsorption, by around 213% and 243%, resp., compared with simple MDC, prepared without KOH. Addnl., the new adsorbent showed around 5-6 times efficiency in removal of such adsorbates to that of conventional activated carbon. The maximum adsorption capacities (Qm) of the studied adsorbent for quinoline and indole also stand at the first and second positions, resp., among the carbon-based adsorbents reported so far. Moreover, compared with other studied adsorbents, the Cu2O-incorporated MDCs had a good selectivity towards both adsorbates, especially during the adsorptions in the presence of toluene as a co-solvent. The remarkable adsorptions with Cu2O/MDC were explained by the π-complexation and huge porosity. In addition, the adsorbents could be regenerated for several cycles via a simple solvent wash. In the experiment, the researchers used 1H-Indole(cas: 120-72-9Formula: C8H7N)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Formula: C8H7N

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Novel [(N-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and in silico studies》 was written by Al-Warhi, Tarfah; Abo-Ashour, Mahmoud F.; Almahli, Hadia; Alotaibi, Ohoud J.; Al-Sanea, Mohammad M.; Al-Ansary, Ghada H.; Ahmed, Hanaa Y.; Elaasser, Mahmoud M.; Eldehna, Wagdy M.; Abdel-Aziz, Hatem A.. Synthetic Route of C8H7N And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020. The article conveys some information:

As a continuation for our previous work, a novel set of N-alkylindole-isatin conjugates is here designed and synthesized with the prime aim to develop more efficient isatin-based antitumor candidates. Utilizing the SAR outputs from the previous study, our design here is based on appending four alkyl groups with different length (Et and n-propyl), bulkiness (iso-propyl) and unsaturation (allyl) on N-1 of indole motif, with subsequent conjugation with different N-unsubstituted isatin moieties to furnish the target conjugates. As planned, the adopted strategy achieved a substantial improvement in the growth inhibitory profile for the target conjugates in comparison to the reported lead . The best results were obtained with N-propylindole -5-methylisatin hybrid which displayed broad spectrum anti-proliferative action with efficient sub-panel GI50 (MG-MID) range from 1.33 to 4.23 μM, and promising full-panel GI50 (MG-MID) equals 3.10 μM, at the NCI five-dose assay. Also, hybrid was able to provoke cell cycle disturbance and apoptosis in breast T-47D cells as evidenced by the DNA flow cytometry and Annexin V-FITC/PI assays. Furthermore, hybrid exhibited good inhibitory action against cell cycle regulator CDK2 protein kinase and the anti-apoptotic Bcl-2 protein (IC50= 0.85 ± 0.03 and 0.46 ± 0.02 μM, resp.). Interestingly, mol. docking for hybrid in CDK2 and Bcl-2 active sites unveiled that N-Pr group is involved in significant hydrophobic interactions. Taken together, the results suggested conjugate as a promising lead for further development and optimization as an efficient antitumor drug. The experimental process involved the reaction of 1H-Indole(cas: 120-72-9Synthetic Route of C8H7N)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Synthetic Route of C8H7N

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Tripodal molecular propellers perturb microtubule dynamics: indole acts as a blade and plays a crucial role in anticancer activity》 was written by Barman, Surajit; Das, Gaurav; Mondal, Prasenjit; Pradhan, Krishnangsu; Jana, Batakrishna; Bhunia, Debmalya; Saha, Abhijit; Kar, Chirantan; Ghosh, Surajit. Application In Synthesis of 1H-IndoleThis research focused ontripodal mol microtubule dynamics indole anticancer activity. The article conveys some information:

An indole-rich tripodal microtubule inhibitor is designed, which binds at the DCVJ site of tubulin and inhibits its polymerization It causes apoptotic death of cancer cells without affecting normal cells and inhibits the growth of tumors. Finally, STD-NMR and TR-NOESY experiments reveal that the indole appendages play a crucial role in interacting with tubulin. In the experiment, the researchers used 1H-Indole(cas: 120-72-9Application In Synthesis of 1H-Indole)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application In Synthesis of 1H-Indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-blockIn 2020 ,《On the possibility of direct triplet state excitation of indole》 appeared in Journal of Photochemistry and Photobiology, B: Biology. The author of the article were Chavez, Jose; Ceresa, Luca; Kitchner, Emma; Kimball, Joseph; Shtoyko, Tanya; Fudala, Rafal; Borejdo, Julian; Gryczynski, Zygmunt; Gryczynski, Ignacy. The article conveys some information:

We studied the luminescence properties of indole in poly (vinyl alc.) (PVA) film. The indole mols. are effectively immobilized in this polymer film and display both fluorescence and phosphorescence emission at room temperature We noticed that the phosphorescence of indole in PVA film can be effectively excited at a longer wavelength than its typical singlet to triplet population route involving intersystem crossing. The maximum of the phosphorescence excitation is about 410 nm which corresponds to the energy of indole triplet state. Interestingly, the phosphorescence anisotropy excited with the longer wavelength (405 nm) is pos. and reaches a value of about 0.25 in contrast to the phosphorescence anisotropy excited within the indole singlet absorption spectrum (290 nm), which is neg. Very different temperature dependences have been observed for fluorescence and phosphorescence of indole in PVA film. While fluorescence depends minimally, the phosphorescence decreases with temperature dramatically. The fluorescence lifetime was measured to be a single component 4.78 ns while the intensity weighted average phosphorescence lifetime with 290 nm and 405 nm excitations were 6.57 and 5.62 ms, resp. We believe that the possibility of the excitation of indole phosphorescence in the blue region of visible light and its high anisotropy opens a new avenue for future protein studies. The experimental process involved the reaction of 1H-Indole(cas: 120-72-9Category: indole-building-block)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Chang, Chieh-Yu; Lin, Yu-Huan; Wu, Yen-Ku. SDS of cas: 399-52-0. The article was titled 《Palladium-catalyzed N1-selective allylation of indoles with allylic alcohols promoted by titanium tetraisopropoxide》. The information in the text is summarized as follows:

The direct N1-selective allylation of indoles with allylic alcs. has been accomplished by synergistic functions of palladium catalysts and titanium tetraisopropoxide. The site selectivity is notably different from that observed in other related transition metal-catalyzed approaches. This chem. provides a facile route to a variety of allylated indoles I (R = 5-MeO, 4-MeO, 6-MeO, etc.; R1 = Me, H, Ph, etc.) in synthetically useful yields. The utility of this simple allylation reaction was demonstrated with the first total synthesis of (+)-N-(4′-hydroxyprenyl)-cyclo(alanyltryptophyl), which was completed in five steps, starting from L-tryptophan Me ester hydrochloride. The experimental part of the paper was very detailed, including the reaction process of 5-Fluoro-1H-indole(cas: 399-52-0SDS of cas: 399-52-0)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.SDS of cas: 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 120-72-9In 2019 ,《Enhanced anaerobic biodegradation efficiency and mechanism of quinoline, pyridine, and indole in coal gasification wastewater》 appeared in Chemical Engineering Journal (Amsterdam, Netherlands). The author of the article were Shi, Jingxin; Xu, Chunyan; Han, Yuxing; Han, Hongjun. The article conveys some information:

Anaerobic bottle experiments were operated in parallel for 160 consecutive days for raw (R1), Polyurethane (R2), and Fe3O4@Cu/Polyurethane (R3) biodegradation of selected nitrogen-heterocyclic (NHCs) in coal gasification wastewater. The addition of Fe3O4@Cu/Polyurethane absolutely had an enhancement of microorganism for the degradation of NHCs. The results of GC-MS showed that the first step of anaerobic degradation of NHCs was the opening of nitrogen heterocyclic ring, the second step was the release of ammonia nitrogen and the opening of benzene ring. In R3, direct interspecies electron transfer (DIET) guided by Fe3O4@Cu could realize the rapid transfer of electrons and avoid the accumulation of electrons in the degradation of the NHCs. Furthermore, acute toxicity anal. showed that under the enhancement of Fe3O4@Cu/Polyurethane, the selected NHCs was degraded effectively and the toxic inhibition of selected NHCs on living organisms decreased effectively. Finally, high-throughput 16S rRNA pyrosequencing showed that the dominant strains were dispersed more balanced with the assist of Fe3O4@Cu/Polyurethane. In addition to this study using 1H-Indole, there are many other studies that have used 1H-Indole(cas: 120-72-9Product Details of 120-72-9) was used in this study.

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Product Details of 120-72-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles