Tag: 1215-59-4

1215-59-4, 5-(Benzyloxy)-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of phosphorus oxychloride (2.29 mL, 24.6 mmol) in DMF (15 mL), was added a solution of 5-benzyloxyindole (5.00 g, 22.4 mmol) in DMF (20 mL) at room temperature. After 30 min, the reaction mixture was poured into ice-water (50 mL). To this mixture was added solid NaOH (4.80 g, 0.112 mol) and water (50 mL). The precipitate was collected, washed with EtOH, and dried to give 4.67 g (83%) of compound 6o. 1H NMR (400 MHz, DMSO-d6) delta 12.01 (s, 1H), 9.89 (s, 1H), 8.21 (s, 1H), 7.68 (m, 1H), 7.49-7.30 (m, 6H), 6.97 (m, 1H), 5.12 (s, 2H) ppm; MS (m/e) 251 (M), 252 (M+H).

The synthetic route of 1215-59-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Cephalon, Inc.; US2007/299061; (2007); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1215-59-4,5-(Benzyloxy)-1H-indole,as a common compound, the synthetic route is as follows.

4.1 To 6.7 g (30 mmol) 5-benzyloxyindole and 6.6 g (30 mmol) di-tert.-butyldicarbonate in 80 ml DMF were added 3.7 g (33 mmol) potassium tert. butylate at RT and the mixture was stirred at 60 C. for 4 h, cooled to RT and ether /0.5 M HC1 were added. The inorganic phase was extracted with ether, the combined organic phases were washed with water and dried over Na2SO4. Evaporation yielded crude 5-Benzyloxy-indole-1-carboxylic acid tert-butyl ester as colorless oil, MS: 323 (M).

The synthetic route of 1215-59-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ackermann, Jean; Aebi, Johannes; Dehmlow, Henrietta; Morand, Olivier; Panday, Narendra; Weller, Thomas; US2002/103247; (2002); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles