With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128742-76-7,Methyl 1-methyl-1H-indole-5-carboxylate,as a common compound, the synthetic route is as follows.
A solution of l-methyl-l//’-indole-5-carboxylic acid methyl ester (0.38 g, 2.0 mmol), prepared using procedures as described in Example 1, Ag?O (0.51 g, 2.2 mmol), 4-nitro-benzyl bromide (0.48 g, 2.2 mmol) and dioxane (6 mL) was heated to reflux for 25 hr, then more 4-nitro-benzyl bromide (0.48 g, 2.2 mmol) was added and the solution was heated at reflux an additional 4 days. After cooling to room temperature, the reaction mixture was diluted with ether (50 mL) and ethyl acetate (50 mL), washed with aq. NH4Cl (50 mL) and then brine (50 mL). The organic layer was dried over MgSO4, filtered and concentrated. The remaining residue was subjected to flash chromatography (ethyl acetate/hexane, 1:4) to provide of l-methyl-3-(4-nitro-phenylmethyl)-l//-indole- 5-carboxylic acid methyl ester (0.38 g, 58% yield). 1H NMR (400 MHz, CDCl3) delta 8.26 (s, IH), 8.16 (d, 2H, J= 8.3 Hz), 7.98 (d, IH, J= 8.3 Hz), 7.45 (d, 2H, J= 8.3 Hz), 7.35 (d, IH, J= 8.3 Hz), 6.90 (s, IH), 4.25 (s, 2H), 3.94 (s, 3H), 3.82 (s, 3H).
The synthetic route of 128742-76-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PHARMACYCLICS, INC.; WO2007/109178; (2007); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles