Tag: 131.1745

Du, Lei et al. published their research in Journal of Animal Physiology and Animal Nutrition | CAS: 83-34-1

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Category: indole-building-block

Soybean oligosaccharides combined with probiotics reduce faecal odour compound content by improving intestinal microbiota in pigs was written by Du, Lei;Qiu, Xiaoyu;Zhu, Siyuan;Liu, Jingbo;Wang, Jing;Wang, Qi;Liu, Zuohua;Yang, Feiyun;Yun, Tingting;Qi, Renli. And the article was included in Journal of Animal Physiology and Animal Nutrition.Category: indole-building-block This article mentions the following:

As a potential prebiotic, soybean oligosaccharides (SBOS) can improve animal health by modulating gut microbiota. The aim of this study was to investigate the different effects of supplementing SBOS and supplementing SBOS plus probiotic on the growth and health of pigs. Three groups of growing pigs (n = 12) were fed with basal diet (Control), basal diet + 0.5% SBOS (SBOS), or basal diet +0.5% SBOS + 0.1% compound probiotics (SOP) for 42 days. Results showed that SBOS and SOP treatments had pos. effects on the pigs in the experiment, and the latter was more effective. Compared with the control pigs, the average daily gain of SBOS group and SOP group slightly increased, SOP significantly increased the serum levels of growth hormone and thyroid hormone T3. Importantly, serum concentrations of Ig (IgA, IgG and IgM), total antioxidant capacity and superoxide dismutase in both treatments were increased significantly, SOP group most. Moreover, the faecal odor compounds of pigs, especially skatole, were significantly reduced by the treatments. Addnl., SOP significantly increased the diversity and richness of the faecal microbiota, both the treatments increased genera of norank_f_Muribaculaceae and Ruminococcaceae but reduced Lactobacillus. Correlation anal. indicated that Lactobacillus was significantly pos. correlated with odor compounds, while Ruminococcaceae was the opposite. Conclusively, synbiotics combined with SBOS and probiotics had stronger promotion effects on the growth and health of pigs. In the experiment, the researchers used many compounds, for example, 3-Methyl-1H-indole (cas: 83-34-1Category: indole-building-block).

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wu, Yu et al. published their research in Asian Journal of Organic Chemistry in 2022 | CAS: 83-34-1

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Name: 3-Methyl-1H-indole

Organocatalytic Enantioselective Construction of Axially Chiral Tetrasubstituted Allenes via 1,6-Addition of Alkynyl Indole Imine Methides with 2-Substituted Indoles was written by Wu, Yu;Yue, Zhibin;Qian, Chenxiao;Chen, Xuling;Li, Fushuai;Li, Pengfei;Li, Wenjun. And the article was included in Asian Journal of Organic Chemistry in 2022.Name: 3-Methyl-1H-indole This article mentions the following:

An organocatalytic construction of axially chiral tetrasubstituted allenes I [R1 = H, 5-F, 6-OMe, etc.; R2 = H, F, Cl, Br; R3 = Me, t-Bu, Ph, etc.; R4 = Et, i-Pr, t-Bu, Bn; Ar1 = Ph, 4-FC6H4, 3-FC6H4, 3-MeC6H4] featuring indole skeletons was established. With the aid of chiral phosphoric acid, alkynyl indole imine methides were formed in situ from 伪-(3-indolyl) propargylic alcs., followed by the asym. 1,6-conjugate addition with 2-substituted indoles, furnishing axially chiral indole-containing tetrasubstituted allenes in generally high yields and enantioselectivities. In the experiment, the researchers used many compounds, for example, 3-Methyl-1H-indole (cas: 83-34-1Name: 3-Methyl-1H-indole).

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Name: 3-Methyl-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Bone, Christine et al. published their research in Metabolites in 2022 | CAS: 83-34-1

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). COA of Formula: C9H9N

Nuclear Receptor Pathways Mediating the Development of Boar Taint was written by Bone, Christine;Squires, E. James. And the article was included in Metabolites in 2022.COA of Formula: C9H9N This article mentions the following:

The nuclear receptors PXR, CAR, and FXR are activated by various ligands and function as transcription factors to control the expression of genes that regulate the synthesis and metabolism of androstenone and skatole. These compounds are produced in entire male pigs and accumulate in the fat to cause the development of a meat quality issue known as boar taint. The extent of this accumulation is influenced by the synthesis and hepatic clearance of androstenone and skatole. For this reason, PXR, CAR, and FXR-mediated signaling pathways have garnered interest as potential targets for specialized treatments designed to reduce the development of boar taint. Recent research has also identified several metabolites produced by gut microbes that act as ligands for these nuclear receptors (e.g., tryptophan metabolites, short-chain fatty acids, bile acids); however, the connection between the gut microbiome and boar taint development is not clear. In this review, we describe the nuclear receptor signaling pathways that regulate the synthesis and metabolism of boar taint compounds and outline the genes involved. We also discuss several microbial-derived metabolites and dietary additives that are known or suspected nuclear receptor ligands and suggest how these compounds could be used to develop novel treatments for boar taint. In the experiment, the researchers used many compounds, for example, 3-Methyl-1H-indole (cas: 83-34-1COA of Formula: C9H9N).

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). COA of Formula: C9H9N

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Li, Shichen et al. published their research in Synthesis in 2022 | CAS: 83-34-1

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Name: 3-Methyl-1H-indole

A Direct Method for Synthesis of Fluorinated Quinazolinones and Quinoxalines Using Fluorinated Acids without Metals or Additives was written by Li, Shichen;Lv, Xueyan;Ren, Jianing;Feng, Lei;Ma, Chen. And the article was included in Synthesis in 2022.Name: 3-Methyl-1H-indole This article mentions the following:

A direct method using trifluoroacetic acid as a CF3 source for the synthesis of 2-(trifluoromethyl)quinazolin-4-ones and 4-(trifluoromethyl)pyrrolo/indolo[1,2- a]quinoxalines without any catalysts or additives was reported; a wide range of fluorinated compounds were obtained in 52%-94% yield. In the experiment, the researchers used many compounds, for example, 3-Methyl-1H-indole (cas: 83-34-1Name: 3-Methyl-1H-indole).

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Name: 3-Methyl-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wu, Yu et al. published their research in Asian Journal of Organic Chemistry in 2022 | CAS: 83-34-1

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Name: 3-Methyl-1H-indole

Organocatalytic Enantioselective Construction of Axially Chiral Tetrasubstituted Allenes via 1,6-Addition of Alkynyl Indole Imine Methides with 2-Substituted Indoles was written by Wu, Yu;Yue, Zhibin;Qian, Chenxiao;Chen, Xuling;Li, Fushuai;Li, Pengfei;Li, Wenjun. And the article was included in Asian Journal of Organic Chemistry in 2022.Name: 3-Methyl-1H-indole This article mentions the following:

An organocatalytic construction of axially chiral tetrasubstituted allenes I [R1 = H, 5-F, 6-OMe, etc.; R2 = H, F, Cl, Br; R3 = Me, t-Bu, Ph, etc.; R4 = Et, i-Pr, t-Bu, Bn; Ar1 = Ph, 4-FC6H4, 3-FC6H4, 3-MeC6H4] featuring indole skeletons was established. With the aid of chiral phosphoric acid, alkynyl indole imine methides were formed in situ from α-(3-indolyl) propargylic alcs., followed by the asym. 1,6-conjugate addition with 2-substituted indoles, furnishing axially chiral indole-containing tetrasubstituted allenes in generally high yields and enantioselectivities. In the experiment, the researchers used many compounds, for example, 3-Methyl-1H-indole (cas: 83-34-1Name: 3-Methyl-1H-indole).

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Name: 3-Methyl-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Bone, Christine et al. published their research in Metabolites in 2022 | CAS: 83-34-1

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). COA of Formula: C9H9N

Nuclear Receptor Pathways Mediating the Development of Boar Taint was written by Bone, Christine;Squires, E. James. And the article was included in Metabolites in 2022.COA of Formula: C9H9N This article mentions the following:

The nuclear receptors PXR, CAR, and FXR are activated by various ligands and function as transcription factors to control the expression of genes that regulate the synthesis and metabolism of androstenone and skatole. These compounds are produced in entire male pigs and accumulate in the fat to cause the development of a meat quality issue known as boar taint. The extent of this accumulation is influenced by the synthesis and hepatic clearance of androstenone and skatole. For this reason, PXR, CAR, and FXR-mediated signaling pathways have garnered interest as potential targets for specialized treatments designed to reduce the development of boar taint. Recent research has also identified several metabolites produced by gut microbes that act as ligands for these nuclear receptors (e.g., tryptophan metabolites, short-chain fatty acids, bile acids); however, the connection between the gut microbiome and boar taint development is not clear. In this review, we describe the nuclear receptor signaling pathways that regulate the synthesis and metabolism of boar taint compounds and outline the genes involved. We also discuss several microbial-derived metabolites and dietary additives that are known or suspected nuclear receptor ligands and suggest how these compounds could be used to develop novel treatments for boar taint. In the experiment, the researchers used many compounds, for example, 3-Methyl-1H-indole (cas: 83-34-1COA of Formula: C9H9N).

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). COA of Formula: C9H9N

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Li, Shichen et al. published their research in Synthesis in 2022 | CAS: 83-34-1

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Name: 3-Methyl-1H-indole

A Direct Method for Synthesis of Fluorinated Quinazolinones and Quinoxalines Using Fluorinated Acids without Metals or Additives was written by Li, Shichen;Lv, Xueyan;Ren, Jianing;Feng, Lei;Ma, Chen. And the article was included in Synthesis in 2022.Name: 3-Methyl-1H-indole This article mentions the following:

A direct method using trifluoroacetic acid as a CF3 source for the synthesis of 2-(trifluoromethyl)quinazolin-4-ones and 4-(trifluoromethyl)pyrrolo/indolo[1,2- a]quinoxalines without any catalysts or additives was reported; a wide range of fluorinated compounds were obtained in 52%-94% yield. In the experiment, the researchers used many compounds, for example, 3-Methyl-1H-indole (cas: 83-34-1Name: 3-Methyl-1H-indole).

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Name: 3-Methyl-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Li, Shichen et al. published their research in Synthesis in 2022 | CAS: 83-34-1

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Name: 3-Methyl-1H-indole

A Direct Method for Synthesis of Fluorinated Quinazolinones and Quinoxalines Using Fluorinated Acids without Metals or Additives was written by Li, Shichen;Lv, Xueyan;Ren, Jianing;Feng, Lei;Ma, Chen. And the article was included in Synthesis in 2022.Name: 3-Methyl-1H-indole This article mentions the following:

A direct method using trifluoroacetic acid as a CF3 source for the synthesis of 2-(trifluoromethyl)quinazolin-4-ones and 4-(trifluoromethyl)pyrrolo/indolo[1,2- a]quinoxalines without any catalysts or additives was reported; a wide range of fluorinated compounds were obtained in 52%-94% yield. In the experiment, the researchers used many compounds, for example, 3-Methyl-1H-indole (cas: 83-34-1Name: 3-Methyl-1H-indole).

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Name: 3-Methyl-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Bone, Christine et al. published their research in Metabolites in 2022 | CAS: 83-34-1

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). COA of Formula: C9H9N

Nuclear Receptor Pathways Mediating the Development of Boar Taint was written by Bone, Christine;Squires, E. James. And the article was included in Metabolites in 2022.COA of Formula: C9H9N This article mentions the following:

The nuclear receptors PXR, CAR, and FXR are activated by various ligands and function as transcription factors to control the expression of genes that regulate the synthesis and metabolism of androstenone and skatole. These compounds are produced in entire male pigs and accumulate in the fat to cause the development of a meat quality issue known as boar taint. The extent of this accumulation is influenced by the synthesis and hepatic clearance of androstenone and skatole. For this reason, PXR, CAR, and FXR-mediated signaling pathways have garnered interest as potential targets for specialized treatments designed to reduce the development of boar taint. Recent research has also identified several metabolites produced by gut microbes that act as ligands for these nuclear receptors (e.g., tryptophan metabolites, short-chain fatty acids, bile acids); however, the connection between the gut microbiome and boar taint development is not clear. In this review, we describe the nuclear receptor signaling pathways that regulate the synthesis and metabolism of boar taint compounds and outline the genes involved. We also discuss several microbial-derived metabolites and dietary additives that are known or suspected nuclear receptor ligands and suggest how these compounds could be used to develop novel treatments for boar taint. In the experiment, the researchers used many compounds, for example, 3-Methyl-1H-indole (cas: 83-34-1COA of Formula: C9H9N).

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). COA of Formula: C9H9N

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Li, Shichen et al. published their research in Synthesis in 2022 | CAS: 83-34-1

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Name: 3-Methyl-1H-indole

A Direct Method for Synthesis of Fluorinated Quinazolinones and Quinoxalines Using Fluorinated Acids without Metals or Additives was written by Li, Shichen;Lv, Xueyan;Ren, Jianing;Feng, Lei;Ma, Chen. And the article was included in Synthesis in 2022.Name: 3-Methyl-1H-indole This article mentions the following:

A direct method using trifluoroacetic acid as a CF3 source for the synthesis of 2-(trifluoromethyl)quinazolin-4-ones and 4-(trifluoromethyl)pyrrolo/indolo[1,2- a]quinoxalines without any catalysts or additives was reported; a wide range of fluorinated compounds were obtained in 52%-94% yield. In the experiment, the researchers used many compounds, for example, 3-Methyl-1H-indole (cas: 83-34-1Name: 3-Methyl-1H-indole).

3-Methyl-1H-indole (cas: 83-34-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Name: 3-Methyl-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles