Tag: 133.15

Herbig, Marcus et al. published their research in Zeitschrift fuer Anorganische und Allgemeine Chemie in 2019 | CAS: 480-91-1

Isoindolin-1-one (cas: 480-91-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Electric Literature of C8H7NO

Lactamomethylsilanes – Synthesis, Structures, and Reactivity towards CO2 and Phenyl isocyanate was written by Herbig, Marcus;Boehme, Uwe;Kroke, Edwin. And the article was included in Zeitschrift fuer Anorganische und Allgemeine Chemie in 2019.Electric Literature of C8H7NO This article mentions the following:

Lactamomethylsilanes of 纬-butyrolactam, 未-valerolactam, 蔚-caprolactam, and 1-isoindolinone (phthalimidine) with up to three Me moieties were synthesized according to the chem. formula MexSiLac(4-x) (x = 0, 1, 2, and 3). Using the lactams as starting materials four synthetic routes were tested: salt elimination, transsilylation, transamination, and metalation of the lactames followed by reaction with methylchlorosilanes. All products were analyzed by NMR (1H, 13C and 29Si) and RAMAN spectroscopy. Selected solid products were crystallized and the mol. structure was determined by single-crystal x-ray diffraction. The reactivity of the lactamomethylsilanes towards Ph isocyanate and CO2 was studied. In the experiment, the researchers used many compounds, for example, Isoindolin-1-one (cas: 480-91-1Electric Literature of C8H7NO).

Isoindolin-1-one (cas: 480-91-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Electric Literature of C8H7NO

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Hearn, K. N. et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2017 | CAS: 480-91-1

Isoindolin-1-one (cas: 480-91-1) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). SDS of cas: 480-91-1

Modular synthesis of 4-aminocarbonyl substituted 1,8-naphthalimides and application in single molecule fluorescence detection was written by Hearn, K. N.;Nalder, T. D.;Cox, R. P.;Maynard, H. D.;Bell, T. D. M.;Pfeffer, F. M.;Ashton, T. D.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.SDS of cas: 480-91-1 This article mentions the following:

Robust methodol. to install amide, carbamate, urea and sulfonamide functionality to the 1,8-naphthalimide scaffold has been developed and exemplified. New benzamidonaphthalimide 6, synthesized using this approach, was found to be sensitive to base whereupon fluorescence emission strongly increases (>10-fold) and red-shifts (>4000 cm-1). The optical properties of deprotonated 6 allow for single mol. fluorescence detection, the first example of such behavior from this class of fluorophore. In the experiment, the researchers used many compounds, for example, Isoindolin-1-one (cas: 480-91-1SDS of cas: 480-91-1).

Isoindolin-1-one (cas: 480-91-1) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). SDS of cas: 480-91-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Fang, Zhang et al. published their research in European Journal of Organic Chemistry in 2022 | CAS: 480-91-1

Isoindolin-1-one (cas: 480-91-1) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Reference of 480-91-1

A New Approach to Isoindolinones: Rhodium(III)-Catalyzed [3+2] Annulation Reactions of N-Methoxybenzamides with Bis(tosylamido)methane was written by Fang, Zhang;Shu, Sai;Zhou, Guanyu;Deng, Zefeng;Huang, Pengcheng;Li, Bao;Zhao, Yingsheng. And the article was included in European Journal of Organic Chemistry in 2022.Reference of 480-91-1 This article mentions the following:

A new approach to the synthesis of isoindolinones I (R = H, Me, OMe, etc.; R1 = Me, OPh, Cl, etc.; R2 = Cl, Me, (cyclopropylmethyl)oxidanyl, etc.; R3 = H, Cl; R4 = H, 2-Me, 4-Br, etc.) via direct coupling of N-methoxybenzamides 2R-3R1-4R2-5R3C6HC(O)NHOMe and bis(tosylamido)methane (R4NH)2CH2 with rhodium(III) as catalyst has been developed. The reaction is performed under mild conditions without oxidant, and is compatible with various functional groups. Compared with the previously reported methods for constructing isoindolinone skeletons, this method involves a novel [3+2] cyclization, and affords a wide variety of isoindolinones I in moderate to excellent yields. In the experiment, the researchers used many compounds, for example, Isoindolin-1-one (cas: 480-91-1Reference of 480-91-1).

Isoindolin-1-one (cas: 480-91-1) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Reference of 480-91-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Hearn, K. N. et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2017 | CAS: 480-91-1

Isoindolin-1-one (cas: 480-91-1) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). SDS of cas: 480-91-1

Modular synthesis of 4-aminocarbonyl substituted 1,8-naphthalimides and application in single molecule fluorescence detection was written by Hearn, K. N.;Nalder, T. D.;Cox, R. P.;Maynard, H. D.;Bell, T. D. M.;Pfeffer, F. M.;Ashton, T. D.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.SDS of cas: 480-91-1 This article mentions the following:

Robust methodol. to install amide, carbamate, urea and sulfonamide functionality to the 1,8-naphthalimide scaffold has been developed and exemplified. New benzamidonaphthalimide 6, synthesized using this approach, was found to be sensitive to base whereupon fluorescence emission strongly increases (>10-fold) and red-shifts (>4000 cm-1). The optical properties of deprotonated 6 allow for single mol. fluorescence detection, the first example of such behavior from this class of fluorophore. In the experiment, the researchers used many compounds, for example, Isoindolin-1-one (cas: 480-91-1SDS of cas: 480-91-1).

Isoindolin-1-one (cas: 480-91-1) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). SDS of cas: 480-91-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Fang, Zhang et al. published their research in European Journal of Organic Chemistry in 2022 | CAS: 480-91-1

Isoindolin-1-one (cas: 480-91-1) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Reference of 480-91-1

A New Approach to Isoindolinones: Rhodium(III)-Catalyzed [3+2] Annulation Reactions of N-Methoxybenzamides with Bis(tosylamido)methane was written by Fang, Zhang;Shu, Sai;Zhou, Guanyu;Deng, Zefeng;Huang, Pengcheng;Li, Bao;Zhao, Yingsheng. And the article was included in European Journal of Organic Chemistry in 2022.Reference of 480-91-1 This article mentions the following:

A new approach to the synthesis of isoindolinones I (R = H, Me, OMe, etc.; R1 = Me, OPh, Cl, etc.; R2 = Cl, Me, (cyclopropylmethyl)oxidanyl, etc.; R3 = H, Cl; R4 = H, 2-Me, 4-Br, etc.) via direct coupling of N-methoxybenzamides 2R-3R1-4R2-5R3C6HC(O)NHOMe and bis(tosylamido)methane (R4NH)2CH2 with rhodium(III) as catalyst has been developed. The reaction is performed under mild conditions without oxidant, and is compatible with various functional groups. Compared with the previously reported methods for constructing isoindolinone skeletons, this method involves a novel [3+2] cyclization, and affords a wide variety of isoindolinones I in moderate to excellent yields. In the experiment, the researchers used many compounds, for example, Isoindolin-1-one (cas: 480-91-1Reference of 480-91-1).

Isoindolin-1-one (cas: 480-91-1) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Reference of 480-91-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles