Tag: 143612-79-7

143612-79-7, 3-(4-Chlorobutyl)-1H-indole-5-carbonitrile is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the 90cc Acetonitriie added 10 g Methyl-5-(Piperazin -l-yl)-benzofuran- 2- carboxylate , 8.94 g of 3-(4-chlorobuiyl)-l H-indole-5-carbonitrile, 2.64 g Potassium Carbonate, 25.50 g Potassium Iodide and 1.2 g TBAB in catalytic amount. Heated to reflux reaction mass for 24 -30 hrs. Cooled to 25-30C. Added 500 cc aqueous ammonia and 310 cc Acetonitriie and maintained for 72 hrs. Filtered the product at 0-5C after 2 hrs stirring. Washed with water and dried at 60C to obtain 65% 2- benzofurancarboxamide, 5-[4-[4-(5cyano- l H-indol-3-yl)butyl]-l-piperazinyl] Base.

143612-79-7, The synthetic route of 143612-79-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HARMAN FINOCHEM LIMITED; KADAM, Vijay Trimbak; EDAKI, Dhananjay Uddhavrao; ORUGANTI, Nagaraju; MINHAS, Harpreet Singh; MINHAS, Gurpreet Singh; (36 pag.)WO2016/128987; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.143612-79-7,3-(4-Chlorobutyl)-1H-indole-5-carbonitrile,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 3-(4-chlorobutyl)-1H-indole-5-carbonitrile (6a,116 mg, 0.5 mmol), corresponding intermediates 7e (0.5 mmol)and KI (0.05 mmol) was added Et3N (1 mmol). The reaction mixturewas stirred at reflux temperature for 24 h. Then removal thesolvent under vacuum and the residue was purified by columnchromatography (CH3OH:CH2Cl2 = 1:20 to 1:10, v:v) to afford compound2a. Compound 2a was isolated as a yellow powder, 40%yield.

As the paragraph descriping shows that 143612-79-7 is playing an increasingly important role.

Reference£º
Article; Liu, Wenwen; Wang, Huan; Li, Xiaokang; Xu, Yixiang; Zhang, Jian; Wang, Wei; Gong, Qi; Qiu, Xiaoxia; Zhu, Jin; Mao, Fei; Zhang, Haiyan; Li, Jian; Bioorganic and Medicinal Chemistry; vol. 26; 12; (2018); p. 3117 – 3125;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles