Tag: 14430-23-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14430-23-0,5,6-Dimethoxyindole,as a common compound, the synthetic route is as follows.

General procedure: Compounds 4 a-d were prepared according a previously reportedprocedure [40,49]. The appropriate indole 3 a-d (1 mmol)was added to a solution of phosphoryl chloride (0.92 mL, 10 mmol)in dimethylacetamide (2.79 mL, 30 mmol) and the resultingmixture was stirred at room temperature for 24 h. Then, the reactionmixturewas basified with sodium hydroxide solution (4N) andextracted with EtOAc (3 10 mL). The organic phases were driedover Na2SO4 and the solvent removed under reduced pressure. Thefinal compounds were obtained by crystallization with amixture ofEt2O and DCM.

The synthetic route of 14430-23-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ferro, Stefania; De Luca, Laura; Germano, Maria Paola; Buemi, Maria Rosa; Ielo, Laura; Certo, Giovanna; Kanteev, Margarita; Fishman, Ayelet; Rapisarda, Antonio; Gitto, Rosaria; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 591 – 598;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

14430-23-0, 5,6-Dimethoxyindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of appropriate intermediates 10-12 (1 mmol) in diethyl ether (5 mL) the oxalyl chloride (0.173 mL, 2 mmol) was added slowly at 0 C under nitrogen atmosphere. The reaction mixture was stirred at room temperature for 2 h. A saturated aqueous NaHCO3 solution (5 mL) was added to quench the reaction and the mixture was extracted with EtOAc (3 x 10 mL). The combined extracts were dried with dry Na2SO4 and concentrated in vacuo. A mixture of crude compounds (20-22) (1 mmol) and N,N,N,N-tetramethyl- O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate (HBTU) (379 mg, 1 mmol) in dimethylformamide (2 mL) was stirred for 30 min at room temperature. Successively, 4-benzylpiperidine (0.175 mL, 1 mmol) or 4-fluorobenzylpiperidine (193.3 mg, 1 mmol) and TEA (0.139 mL, 1 mmol) were added, the reaction mixture was stirred for 2 h at room temperature. Then the reaction mixture was quenched with H2O (10 mL) and extracted with EtOAc (3 x x10 mL). The combined extracts were dried with dry Na2SO4 and concentrated in vacuo. The crude compounds were purified by flash chromatography (FC) (DCM/MeOH 96:4) and recrystallized by treatment with Et2O to give the desired final products 29, 32-34.

The synthetic route of 14430-23-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gitto, Rosaria; De Luca, Laura; Ferro, Stefania; Russo, Emilio; De Sarro, Giovambattista; Chisari, Mariangela; Ciranna, Lucia; Alvarez-Builla, Julio; Alajarin, Ramon; Buemi, Maria Rosa; Chimirri, Alba; Bioorganic and Medicinal Chemistry; vol. 22; 3; (2014); p. 1040 – 1048;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles