Tag: 147.17

Shigeno, Masanori et al. published their research in Organic Chemistry Frontiers in 2022 | CAS: 13523-92-7

1-Methyl-1H-indol-5-ol (cas: 13523-92-7) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Recommanded Product: 1-Methyl-1H-indol-5-ol

Organic superbase t-Bu-P4-catalyzed demethylations of methoxyarenes was written by Shigeno, Masanori;Hayashi, Kazutoshi;Korenaga, Toshinobu;Nozawa-Kumada, Kanako;Kondo, Yoshinori. And the article was included in Organic Chemistry Frontiers in 2022.Recommanded Product: 1-Methyl-1H-indol-5-ol This article mentions the following:

The organic superbase t-Bu-P4 catalyzes the demethylation reactions of methoxyarenes ROMe [R = 4-cyanophenyl, 1-oxo-2,3-dihydro-1H-inden-5-yl, 1-benzothiophen-5-yl, etc.] in the presence of alkanethiol and hexamethyldisilazane was reported. The system can efficiently convert a variety of substrates, including electron-deficient, -neutral, and -rich substrates and heteroaromatic substrates, and displays excellent functional group tolerance. Computational studies show that the high reactivity achieved by t-Bu-P4 is due to the formation of the nucleophilic naked thiolate species. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-indol-5-ol (cas: 13523-92-7Recommanded Product: 1-Methyl-1H-indol-5-ol).

1-Methyl-1H-indol-5-ol (cas: 13523-92-7) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Recommanded Product: 1-Methyl-1H-indol-5-ol

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Bartoccini, Francesca et al. published their research in Journal of Organic Chemistry in 2018 | CAS: 13523-92-7

1-Methyl-1H-indol-5-ol (cas: 13523-92-7) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Computed Properties of C9H9NO

Organocatalytic Aza-Friedel-Crafts/Lactonization Domino Reaction of Naphthols and Phenols with 2-Acetamidoacrylate to Naphtho- and Benzofuranones Bearing a Quaternary Center at the C3 Position was written by Bartoccini, Francesca;Mari, Michele;Retini, Michele;Bartolucci, Silvia;Piersanti, Giovanni. And the article was included in Journal of Organic Chemistry in 2018.Computed Properties of C9H9NO This article mentions the following:

N-Acetyl ketimine generated from Me 2-acetamidoacrylate was explored to develop an unprecedented domino aza-Friedel-Crafts/lactonization reaction with naphthols and phenols (including 5-hydroxyindoles). This novel method requires a catalyst loading of only 5 mol % of a phosphoric acid catalyst and provides a new series of 3-NHAc-naphtho- and benzofuranone derivatives bearing tetra-substituted stereogenic centers in moderate-to-good yields. The enantioselective variant using BINOL-derived phosphoric acids was also explored with 1-naphthol, providing the desired product with moderate enantioselectivities (up to 99:1 following recrystallization). In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-indol-5-ol (cas: 13523-92-7Computed Properties of C9H9NO).

1-Methyl-1H-indol-5-ol (cas: 13523-92-7) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Computed Properties of C9H9NO

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Bartoccini, Francesca et al. published their research in Journal of Organic Chemistry in 2018 | CAS: 13523-92-7

1-Methyl-1H-indol-5-ol (cas: 13523-92-7) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Computed Properties of C9H9NO

Organocatalytic Aza-Friedel-Crafts/Lactonization Domino Reaction of Naphthols and Phenols with 2-Acetamidoacrylate to Naphtho- and Benzofuranones Bearing a Quaternary Center at the C3 Position was written by Bartoccini, Francesca;Mari, Michele;Retini, Michele;Bartolucci, Silvia;Piersanti, Giovanni. And the article was included in Journal of Organic Chemistry in 2018.Computed Properties of C9H9NO This article mentions the following:

N-Acetyl ketimine generated from Me 2-acetamidoacrylate was explored to develop an unprecedented domino aza-Friedel-Crafts/lactonization reaction with naphthols and phenols (including 5-hydroxyindoles). This novel method requires a catalyst loading of only 5 mol % of a phosphoric acid catalyst and provides a new series of 3-NHAc-naphtho- and benzofuranone derivatives bearing tetra-substituted stereogenic centers in moderate-to-good yields. The enantioselective variant using BINOL-derived phosphoric acids was also explored with 1-naphthol, providing the desired product with moderate enantioselectivities (up to 99:1 following recrystallization). In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-indol-5-ol (cas: 13523-92-7Computed Properties of C9H9NO).

1-Methyl-1H-indol-5-ol (cas: 13523-92-7) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Computed Properties of C9H9NO

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles