Tag: 151.5929

Combined Experimental and Computational Mechanistic Investigation of the Palladium-Catalyzed Decarboxylative Cross-Coupling of Sodium Benzoates with Chloroarenes was written by Humke, Jenna N.;Daley, Ryan A.;Morrenzin, Aaron S.;Neufeldt, Sharon R.;Topczewski, Joseph J.. And the article was included in Journal of Organic Chemistry in 2021.COA of Formula: C8H6ClN This article mentions the following:

A mechanistic investigation into the palladium-catalyzed decarboxylative cross-coupling of sodium benzoates and chloroarenes was reported here. The reaction was found to be first-order in Pd. A minimal substituent effect was observed with respect to chloroarene, and the reaction was zero-order with respect to chloroarene. Palladium-mediated decarboxylation was assigned as the turnover-limiting step based on an Eyring plot and d. functional theory computations. Catalyst performance was found to vary based on the electrophile, which was best explained by catalyst decomposition at Pd(0). The 1,5-cyclooctadiene (COD) ligand contained in the precatalyst CODPd(CH₂TMS)₂ (Pd1) was shown to be a beneficial additive. The bench-stable Buchwald complex XPhosPdG2 could be used with exogenous COD and 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl (XPhos) instead of complex Pd1. Adding exogenous XPhos significantly increased the catalyst turnover number and enhanced reproducibility. In the experiment, the researchers used many compounds, for example, 6-Chloro-1H-indole (cas: 17422-33-2COA of Formula: C8H6ClN).

6-Chloro-1H-indole (cas: 17422-33-2) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.COA of Formula: C8H6ClN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthesis and cytotoxicity evaluation of olivacine-indole hybrids tethered by alkyl linkers was written by Pis Diez, Cristian M.;Cespedes, Mariela;Di Venosa, Gabriela M.;Calvo, Gustavo;Avigliano, Esteban;Casas, Adriana G.;Palermo, Jorge A.. And the article was included in Natural Product Research in 2022.Name: 6-Chloro-1H-indole This article mentions the following:

In this work, eleven new derivatives were prepared of the alkaloid olivacine (1), which was isolated from the bark of Aspidosperma australe. These compounds are hybrids of olivacine and indoles or carbazole, tethered by alkyl chains of variable lengths (C-4, C-5 or C-6). Compounds showed increased cytotoxicity towards a panel of four cell lines. The subcellular localization of olivacine and of the synthetic derivatives was studied by fluorescence microscopy. The cycles of K562 cells exposed to olivacine or compounds were analyzed by flow cytometry, and showed, for some of the new derivatives, a different profile of cell distribution among the phases of the cycle when compared to olivacine, which is indicative of lysosomal apoptosis. In the experiment, the researchers used many compounds, for example, 6-Chloro-1H-indole (cas: 17422-33-2Name: 6-Chloro-1H-indole).

6-Chloro-1H-indole (cas: 17422-33-2) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Name: 6-Chloro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Combined Experimental and Computational Mechanistic Investigation of the Palladium-Catalyzed Decarboxylative Cross-Coupling of Sodium Benzoates with Chloroarenes was written by Humke, Jenna N.;Daley, Ryan A.;Morrenzin, Aaron S.;Neufeldt, Sharon R.;Topczewski, Joseph J.. And the article was included in Journal of Organic Chemistry in 2021.COA of Formula: C8H6ClN This article mentions the following:

A mechanistic investigation into the palladium-catalyzed decarboxylative cross-coupling of sodium benzoates and chloroarenes was reported here. The reaction was found to be first-order in Pd. A minimal substituent effect was observed with respect to chloroarene, and the reaction was zero-order with respect to chloroarene. Palladium-mediated decarboxylation was assigned as the turnover-limiting step based on an Eyring plot and d. functional theory computations. Catalyst performance was found to vary based on the electrophile, which was best explained by catalyst decomposition at Pd(0). The 1,5-cyclooctadiene (COD) ligand contained in the precatalyst CODPd(CH₂TMS)₂ (Pd1) was shown to be a beneficial additive. The bench-stable Buchwald complex XPhosPdG2 could be used with exogenous COD and 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl (XPhos) instead of complex Pd1. Adding exogenous XPhos significantly increased the catalyst turnover number and enhanced reproducibility. In the experiment, the researchers used many compounds, for example, 6-Chloro-1H-indole (cas: 17422-33-2COA of Formula: C8H6ClN).

6-Chloro-1H-indole (cas: 17422-33-2) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.COA of Formula: C8H6ClN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthesis and cytotoxicity evaluation of olivacine-indole hybrids tethered by alkyl linkers was written by Pis Diez, Cristian M.;Cespedes, Mariela;Di Venosa, Gabriela M.;Calvo, Gustavo;Avigliano, Esteban;Casas, Adriana G.;Palermo, Jorge A.. And the article was included in Natural Product Research in 2022.Name: 6-Chloro-1H-indole This article mentions the following:

In this work, eleven new derivatives were prepared of the alkaloid olivacine (1), which was isolated from the bark of Aspidosperma australe. These compounds are hybrids of olivacine and indoles or carbazole, tethered by alkyl chains of variable lengths (C-4, C-5 or C-6). Compounds showed increased cytotoxicity towards a panel of four cell lines. The subcellular localization of olivacine and of the synthetic derivatives was studied by fluorescence microscopy. The cycles of K562 cells exposed to olivacine or compounds were analyzed by flow cytometry, and showed, for some of the new derivatives, a different profile of cell distribution among the phases of the cycle when compared to olivacine, which is indicative of lysosomal apoptosis. In the experiment, the researchers used many compounds, for example, 6-Chloro-1H-indole (cas: 17422-33-2Name: 6-Chloro-1H-indole).

6-Chloro-1H-indole (cas: 17422-33-2) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Name: 6-Chloro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles