Tag: 161.2004

Ru-catalyzed oxidation and C-C bond formation of indoles for the synthesis of 2-indolyl indolin-3-ones under mild reaction conditions was written by Zhou, Xiao-Yu;Chen, Xia. And the article was included in Canadian Journal of Chemistry in 2020.Synthetic Route of C10H11NO This article mentions the following:

Herein, a ruthenium catalyzed oxidation and C-C bond formation reaction of 2-alkyl or 2-aryl substituted indoles using tert-Bu hydroperoxide (TBHP) as oxidant is described. Coupled with cascade transformation, it provided a mild catalytic oxidation system for the synthesis of 2-indolylindolin-3-ones I (R = Me, Ph, 4-FC₆H₄, etc.; R¹ = H, Me, Et; R² = 5-Me, 5-OMe, 5-Cl) . The reaction could readily occur using RuCl₃·3H₂O as catalyst, and the target product was obtained with medium to high yield. In the experiment, the researchers used many compounds, for example, 5-Methoxy-2-methyl-1H-indole (cas: 1076-74-0Synthetic Route of C10H11NO).

5-Methoxy-2-methyl-1H-indole (cas: 1076-74-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Synthetic Route of C10H11NO

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Cyclization of Vinylketene Dithioacetals: A Synthetic Strategy for Substituted Thiophenes was written by Pan, Ling;Zheng, Baihui;Yang, Xiaohui;Deng, Liping;Li, Yifei;Liu, Qun. And the article was included in Advanced Synthesis & Catalysis in 2021.HPLC of Formula: 1076-74-0 This article mentions the following:

A synthetic strategy for the synthesis of substituted thiophenes is described by the one-pot reaction of indoles with ketene dithioacetals under mild reaction conditions. Promoted by triflic acid (TfOH), the reaction of indoles with the easily available α-acetyl ketene dithioacetals resulted in the formation of vinylketene dithioacetals via condensation instead of the well known nucleophilic addition-alkylthio elimination process. In the presence of CuBr₂, vinylketene dithioacetals can cyclize into the corresponding substituted thiophenes. This transformation may benefit from the acidic reaction conditions and the steric effects of the 2-substituted indoles. In the experiment, the researchers used many compounds, for example, 5-Methoxy-2-methyl-1H-indole (cas: 1076-74-0HPLC of Formula: 1076-74-0).

5-Methoxy-2-methyl-1H-indole (cas: 1076-74-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.HPLC of Formula: 1076-74-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Cyclization of Vinylketene Dithioacetals: A Synthetic Strategy for Substituted Thiophenes was written by Pan, Ling;Zheng, Baihui;Yang, Xiaohui;Deng, Liping;Li, Yifei;Liu, Qun. And the article was included in Advanced Synthesis & Catalysis in 2021.HPLC of Formula: 1076-74-0 This article mentions the following:

A synthetic strategy for the synthesis of substituted thiophenes is described by the one-pot reaction of indoles with ketene dithioacetals under mild reaction conditions. Promoted by triflic acid (TfOH), the reaction of indoles with the easily available α-acetyl ketene dithioacetals resulted in the formation of vinylketene dithioacetals via condensation instead of the well known nucleophilic addition-alkylthio elimination process. In the presence of CuBr₂, vinylketene dithioacetals can cyclize into the corresponding substituted thiophenes. This transformation may benefit from the acidic reaction conditions and the steric effects of the 2-substituted indoles. In the experiment, the researchers used many compounds, for example, 5-Methoxy-2-methyl-1H-indole (cas: 1076-74-0HPLC of Formula: 1076-74-0).

5-Methoxy-2-methyl-1H-indole (cas: 1076-74-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.HPLC of Formula: 1076-74-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Ru-catalyzed oxidation and C-C bond formation of indoles for the synthesis of 2-indolyl indolin-3-ones under mild reaction conditions was written by Zhou, Xiao-Yu;Chen, Xia. And the article was included in Canadian Journal of Chemistry in 2020.Synthetic Route of C10H11NO This article mentions the following:

Herein, a ruthenium catalyzed oxidation and C-C bond formation reaction of 2-alkyl or 2-aryl substituted indoles using tert-Bu hydroperoxide (TBHP) as oxidant is described. Coupled with cascade transformation, it provided a mild catalytic oxidation system for the synthesis of 2-indolylindolin-3-ones I (R = Me, Ph, 4-FC₆H₄, etc.; R¹ = H, Me, Et; R² = 5-Me, 5-OMe, 5-Cl) . The reaction could readily occur using RuCl₃·3H₂O as catalyst, and the target product was obtained with medium to high yield. In the experiment, the researchers used many compounds, for example, 5-Methoxy-2-methyl-1H-indole (cas: 1076-74-0Synthetic Route of C10H11NO).

5-Methoxy-2-methyl-1H-indole (cas: 1076-74-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Synthetic Route of C10H11NO

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Cyclization of Vinylketene Dithioacetals: A Synthetic Strategy for Substituted Thiophenes was written by Pan, Ling;Zheng, Baihui;Yang, Xiaohui;Deng, Liping;Li, Yifei;Liu, Qun. And the article was included in Advanced Synthesis & Catalysis in 2021.HPLC of Formula: 1076-74-0 This article mentions the following:

A synthetic strategy for the synthesis of substituted thiophenes is described by the one-pot reaction of indoles with ketene dithioacetals under mild reaction conditions. Promoted by triflic acid (TfOH), the reaction of indoles with the easily available α-acetyl ketene dithioacetals resulted in the formation of vinylketene dithioacetals via condensation instead of the well known nucleophilic addition-alkylthio elimination process. In the presence of CuBr₂, vinylketene dithioacetals can cyclize into the corresponding substituted thiophenes. This transformation may benefit from the acidic reaction conditions and the steric effects of the 2-substituted indoles. In the experiment, the researchers used many compounds, for example, 5-Methoxy-2-methyl-1H-indole (cas: 1076-74-0HPLC of Formula: 1076-74-0).

5-Methoxy-2-methyl-1H-indole (cas: 1076-74-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.HPLC of Formula: 1076-74-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles