With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16136-58-6,1-Methyl-1H-indole-2-carboxylic acid,as a common compound, the synthetic route is as follows.
To a 0¡ã C. solution of ethyl cis-2-amino-1-cyclohexanecarboxylate HBr salt (9.03 g, 35.8 mmol), 1-methylindole-2-carboxylic acid (6.18 g, 35.3 mmol), HOBT (5.45 g, 40.3 mmol), and EDCI.HCl (7.45 g, 38.9 mmol) in 70 mL of anhydrous DMF was added N-methylmorpholine (7.8 mL, 71 mmol). The reaction mixture was stirred for 24 h at room temperature. The reaction mixture was cooled in an ice bath and treated with 140 mL of water. 140 mL of ethyl acetate was added to the resulting yellow suspension and stirred until the solids dissolved. An additional 140 mL of ethyl acetate was added and the organic layer was separated. The organic layer was washed with two 280 mL portions of 0.5 M HCl, 280 mL of brine, then dried over sodium sulfate, filtered and concentrated to give a crude yellow solid. Purification by column chromatography (30:70, ethyl acetate:hexanes) gave 10.9 g of the product as a pale green-tinted solid. Yield: 90percent, MS: 329 (M+H+), mp=98.1-99.0¡ã C.
As the paragraph descriping shows that 16136-58-6 is playing an increasingly important role.
Reference£º
Patent; Bamberg, Joe Timothy; Gabriel, Tobias; Krauss, Nancy Elisabeth; Mirzadegan, Taraneh; Palmer, Wylie Solang; Smith, David Bernard; US2004/77646; (2004); A1;,
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