Tag: 16732-57-3

16732-57-3, Ethyl 5-nitro-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a dry 250 mL reaction bottle,First add ethanol (80mL),Water (20mL),Acetic acid (10 mL) and iron powder (8.62 g, 0.154 mol);Then heated to 75 C under stirring,Compound 4 (9.00 g, 0.039 mol) was added in portions.After the completion of the dropwise addition, the reaction was kept for 2 hours.Thin layer chromatography to detect the reaction is over,Stop the reaction.The reaction solution is filtered hot, and the filtrate is cooled and then reduced.Concentration by pressure to remove the solvent;After adding 80 mL of water to the viscous liquid obtained by concentration,80 mL of ethyl acetate was added under stirring, and the pH was adjusted to 7-8 with sodium hydrogencarbonate. After liquid filtration, the mixture was separated, and the organic phase was dried over 15 g of anhydrous sodium sulfate for 5h, filtered, and the filtrate was concentrated under reduced pressure. Separation and separation (eluent: petroleum ether: ethyl acetate = 3:1, v/v) gave a red solid product Ethyl 5-aminoindole-2-carboxylate 6.10 g, yield 77.7%.

The synthetic route of 16732-57-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Xiamen University; Wu Zhen; Zhou Hu; Fang Meijuan; Qin Jingbo; Niu Boning; Wang Chaojie; Chen Xiaohui; Tang Bowen; Cao Yin; Lv Ben; (33 pag.)CN109734708; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16732-57-3,Ethyl 5-nitro-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.

Example 10: Synthesis of 1-BENZYL-3-(4-TE7F-BUTYLPHENYL)-5-(LH-PYRROL-L-YL)- LH-INDOLE-2-CARBOXYLIC acid; [0122] Step 1:; A solution of N-BROMOSUCCINIMIDE (0.83 g, 4.7 mmol) in DMF (5 ML) was added dropwise to a stirred solution of ethyl 5-nitro-1H-indole-2-carboxylate (1.0 g, 4.27 mmol) in DMF (5 mL) at 0-5C. After the addition was completed, the reaction was warmed to room temperature and stirring was continued for an additional 1.5 h. The reaction mixture was poured over ice water and the resulting precipitate was collected and dried. The dried solid was re-dissolved in DMF (10 ML) and benzyl bromide (0.68 g, 4.0 mmol) and CS2CO3 (6.56 g, 20 mmol) were added successively. The reaction was stirred for overnight and then diluted with water. The product was extracted with ethyl acetate, dried over magnesium sulfate. Recrystalization from ethyl acetate and hexane gave 0.99 g (57%) of ethyl 1-BENZYL-3-BROMO-5- nitro-1 H-indole-2-carboxylate as an off-white solid : 1H NMR (DMSO-D6) No. 1. 28 (t, J = 7.0 Hz, 3 H), 4.35 (q, J = 7. 0 HZ, 2 H), 5.90 (s, 2 H), 7.00-7. 10 (m, 2 H), 7.20-7. 35 (m, 3 H), 7.95 (d, J= 9.3 Hz, 1 H), 8.25 (dd, J = 9.3, 2.0 Hz, 1 H), 8.48 (d, J = 2.0 Hz, 1 H); MS (ESI) m/z 403/405 (MH+).

16732-57-3 Ethyl 5-nitro-1H-indole-2-carboxylate 280312, aindole-building-block compound, is more and more widely used in various.

Reference£º
Patent; WYETH; WO2005/30756; (2005); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles