Tag: 16732-70-0

16732-70-0, Ethyl 5-bromo-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ethyl 5-bromoindole carboxylate (1 ‘) (0.10 g, 0.373 mmol) was placed in a round bottom flask,10 mL of acetonitrile was added and 3,5-dimethylthiophenol (0.0516 g, 0.373 mmol, 50 muL) and 1-chloromethyl-4-fluoro-1,4-diazabicyclo [2.2. 2] octane bis (tetrafluoroborate) salt (0.10 g, 0.373 mmol).The reaction was continued for 6 hours.Acetonitrile was evaporated to dryness, 30 mL of water was added, the mixture was extracted with methylene chloride (3 ¡Á 10 mL)The organic phases were combined, washed with saturated brine and dried over anhydrous magnesium sulfate. Filtered and concentrated,Purification by column chromatography (ethyl acetate: petroleum ether = 1: 8).The resulting white solid was recrystallized from ethyl acetate / petroleum ether to give 2 ‘. Yield 50.5%.

16732-70-0 Ethyl 5-bromo-1H-indole-2-carboxylate 259091, aindole-building-block compound, is more and more widely used in various.

Reference£º
Patent; Shandong University; Liu Xinyong; Li Xiao; Zhan Peng; (27 pag.)CN105968095; (2016); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16732-70-0,Ethyl 5-bromo-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.

Example 88 5-[l-(2-Oxo-pyrrolidin-l-yl)-ethyl]-lH-indole-2-carboxylic acid (3,5-difluoro-phenyl)- amide a) 5-ri-(2-Oxo-pyrrolidin-l-yl)-vinyll-lH-indole-2-carboxylic acid ethyl ester Palladium- (II) -acetat (17 mg) and tri-(o-tolyl)pho spine (68 mg) were dissolved in DMF (10 mL), then 5-bromo-lH-indole-2-carboxylic acid ethyl ester (400 mg), sodium hydrogen carbonate (501 mg), Nu,Nu-diisopropyl ethyl amine (1.02 mL) and l-vinyl-2-pyrrolidon (207 mg) were added. The reaction was stirred at 125C for 1.5 hours, followed by extraction with ethyl acetate and water. Column chromatography on silica gel using heptane / ethyl acetate (1: 1) yielded the title compound as the minor component of the reaction as a light grey solid (161 mg, 36 %). MS ISP (m/e): 299.2 (100) [(M+H)+].

As the paragraph descriping shows that 16732-70-0 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BAUMANN, Karlheinz; FLOHR, Alexander; JOLIDON, Synese; KNUST, Henner; LUEBBERS, Thomas; NETTEKOVEN, Matthias; WO2014/60386; (2014); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16732-70-0,Ethyl 5-bromo-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.

A mixture of 5-bromoindole-2-carboxylic acid ethyl ester (3.48 g, 13 mmol), 4-tert-butylphenylboronic acid (4.63 g, 26 mmol), K3P04 (9.93 g, 45 mmol), Pd(OAc)2 (146 mg, 0.65 mmol), tri-o-tolylphosphine (396 mg, 1.3 mmol), EtOH (20 ml) and toluene (10 mL) was stirred under argon for 20 min at room temperature, and then heated at 100C for 24 h. The mixture was allowed to cool, poured into NaHC03 (aq. , sat. ) and extracted with EtOAc. The combined extracts were washed with water and brine and then dried over Na2S04. Concentration and purification by chromatography gave the sub-title compound (3.27 g, 78%).

16732-70-0 Ethyl 5-bromo-1H-indole-2-carboxylate 259091, aindole-building-block compound, is more and more widely used in various.

Reference£º
Patent; BIOLIPOX AB; WO2005/123675; (2005); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles