With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1805-65-8,2-(tert-Butyl)-1H-indole,as a common compound, the synthetic route is as follows.
Example 9. Synthesis of 2-tert-butyl-3-isopentyl-1 H-indole. A mixture of trifluoroacetic acid (3.42 g, 30 mmol, 1 .5 eq), palladium (5% on activated carbon, 0.3 g) and dichloromethane (40 mL) was put under hydrogen atmosphere in a 250 mL two neck flask and cooled in an ice bath. To this mixture, a solution of 2-tert-butyl-1 H-lndole (3.46 g, 20 mmol, 1 eq) (obtained in Example 8) and 3-methylbutyraldehyde (1 .9 g, 22 mmol, 1 .1 eq) in dichloromethane (60 mL) was added dropwise. This solution was stirred in a water bath for 5 hours, regularly flushing with hydrogen gas. With the aid of thin layer chromatography (TLC) (hexane:ethyl acetate 9:1 ), the reaction was followed until completion. The mixture was filtered over celite and washed with saturated aqueous sodium carbonate (100 mL). The organic phases were dried over magnesium sulfate and concentrated in vacuo to obtain the title compound as a viscous oil (99%). MW.: 243.39 g/mol. 1H-NMR (500 MHz, CDCI3): delta (ppm) = 0.93 (d, 6 H, CH (CH3)2), 1.37 (s, 1 H, C(CH3)3), 1.47 (m, 2H, i-Pr CH2), 1.65 (m, 1 H, CH (CH3)2), 2.76 (m, 2H, C-C-CH2), 7.00 (m, 2H, ArH), 7.18 (d, 1 H, ArH), 7.42 (d, 1 H, ArH), 7.70 (br. s, 1 H, NH). 13C-NMR (125 MHz, CDCI3): delta (ppm) = 22.69 (CH3), 23.43 (CH2), 28.87 (CH), 30.59 (CH3), 32.95 (C), 40.81 (CH2), 1 10.33 (CH), 1 1 1 .36 (C), 1 18.16 (CH), 1 18.94 (CH), 120.97(CH), 129.83 (C), 134.07 (C), 141 .16 (C).
1805-65-8, The synthetic route of 1805-65-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; UNIVERSITEIT GENT; DU PREZ, Filip; WINNE, Johan; BILLIET, Stijn; DE BRUYCKER, Kevin; WO2015/18928; (2015); A1;,
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