Rapid and selective access to three distinct sets of indole-based heterocycles from a single set of Ugi-adducts under microwave heating was written by Zhang, Lei;Zhao, Fei;Zheng, Mingyue;Zhai, Yun;Liu, Hong. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2013.Category: indole-building-block This article mentions the following:
Three distinct sets of indole-based heterocycles, e.g. I, II and III, were rapidly and selectively synthesized from the same set of Ugi-adducts, e.g. IV, under microwave heating in a reaction-condition-controlled manner. Notably, an unprecedented metal-free intramol. sp3-hybridized C-H arylation using only cesium carbonate was discovered. In the experiment, the researchers used many compounds, for example, (5-Chloro-1H-indol-2-yl)methanol (cas: 53590-47-9Category: indole-building-block).
(5-Chloro-1H-indol-2-yl)methanol (cas: 53590-47-9) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Category: indole-building-block
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles