Tag: 187.2

Nickel(0)-Catalyzed N-Allylation of Amides and p-Toluenesulfonamide with Allylic Alcohols under Neat and Neutral Conditions was written by Azizi, Mohamed Salah;Edder, Youssef;Karim, Abdallah;Sauthier, Mathieu. And the article was included in European Journal of Organic Chemistry in 2016.Reference of 5428-09-1 This article mentions the following:

Nickel(0)-catalyzed direct N-allylation of amides and p-toluenesulfonamide with allylic alcs. took place in the presence of Ni⁰-diphosphine complexes. The corresponding N-allylated (and/or N,N-diallylated) products were obtained in moderate to high yields under neutral conditions. In the experiment, the researchers used many compounds, for example, 2-Allylisoindoline-1,3-dione (cas: 5428-09-1Reference of 5428-09-1).

2-Allylisoindoline-1,3-dione (cas: 5428-09-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Reference of 5428-09-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In(OTf)₃-Catalyzed One-Pot Tandem Mannich and Conia-Ene Cyclization Reaction of N-Propargyl Amido Alcohols with 1,3-Dicarbonyl Compounds: An Approach To Construct Tetrahydro-1H-pyrrolo[2,1-a]isoindolone-1,1-dicarboxylate and Its Application was written by Sahu, Archana Kumari;Unnava, Ramanjaneyulu;Shit, Sudip;Saikia, Anil K.. And the article was included in Journal of Organic Chemistry in 2020.Quality Control of 2-Allylisoindoline-1,3-dione This article mentions the following:

A one-pot tandem reaction has been developed for the synthesis of substituted tetrahydropyrroloisoindolone via Mannich reaction of N-propargyl amido alcs. with 1,3-dicarbonyl compounds followed by Conia-ene cyclization reaction in moderate to good yields catalyzed by indium(III)triflate [In(OTf)₃]. The reaction is highly regioselective with an exo-cyclic double bond in the pyrrolidine ring. The substituted tetrahydropyrroloisoindolone can be converted to 5H-pyrrolo[2,1-a]isoindol-5-one via decarboxylative aromatization reaction. In the experiment, the researchers used many compounds, for example, 2-Allylisoindoline-1,3-dione (cas: 5428-09-1Quality Control of 2-Allylisoindoline-1,3-dione).

2-Allylisoindoline-1,3-dione (cas: 5428-09-1) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Quality Control of 2-Allylisoindoline-1,3-dione

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

A flexible route to substituted hydroxy-cyclopentanones from cyclobutanones was written by Heng, Rama;Zard, Samir Z.. And the article was included in Tetrahedron Letters in 2015.Synthetic Route of C11H9NO2 This article mentions the following:

Acetonyl radicals derived from TBS-protected 1-(α-xanthylacetyl)-1-cyclobutanes readily undergo an addition reaction with un-activated alkenes. Deprotection of the resulting adducts with Et₄NF/THF and exposure to silica gel cause ring expansion to give substituted (hydroxy)cyclopentanone derivatives Products of addition to allyl cyanide also underwent β-elimination of the xanthate when treated with Et₄NF/THF. In the experiment, the researchers used many compounds, for example, 2-Allylisoindoline-1,3-dione (cas: 5428-09-1Synthetic Route of C11H9NO2).

2-Allylisoindoline-1,3-dione (cas: 5428-09-1) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Synthetic Route of C11H9NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Copper-Catalyzed Carbotrifluoromethylation of Unactivated Alkenes Driven by Trifluoromethylation of Alkyl Radicals was written by Zhang, Zhenzhen;Zhu, Lin;Li, Chaozhong. And the article was included in Chinese Journal of Chemistry in 2019.Electric Literature of C11H9NO2 This article mentions the following:

Herein an unprecedented protocol for radical carbotrifluoromethylation of unactivated alkenes is reported. With Cu(OTf)₂ as the catalyst, the reaction of unactivated alkenes, TMSCF₃ and activated alkyl chlorides at room temperature provides the corresponding carbotrifluoromethylation products in satisfactory yields. Directed by trifluoromethylation of alkyl radicals, the method exhibits an excellent regioselectivity that is opposite to those driven by CF₃ radical addition In the experiment, the researchers used many compounds, for example, 2-Allylisoindoline-1,3-dione (cas: 5428-09-1Electric Literature of C11H9NO2).

2-Allylisoindoline-1,3-dione (cas: 5428-09-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Electric Literature of C11H9NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Copper-Catalyzed Intermolecular Trifluoromethylthiocyanation of Alkenes: Convenient Access to CF₃-Containing Alkyl Thiocyanates was written by Liang, Zhaoli;Wang, Fei;Chen, Pinhong;Liu, Guosheng. And the article was included in Organic Letters in 2015.HPLC of Formula: 5428-09-1 This article mentions the following:

A highly selective and efficient approach for the direct trifluoromethylthiocyanation of alkenes has been developed using trimethylsilyl isothiocyanate (TMSNCS) as the thiocyanating agent and Togni reagent as the CF₃ source in the presence of copper(I) catalyst. Both activated and unactivated alkenes work well to deliver various CF₃-containing thiocyanates. In the experiment, the researchers used many compounds, for example, 2-Allylisoindoline-1,3-dione (cas: 5428-09-1HPLC of Formula: 5428-09-1).

2-Allylisoindoline-1,3-dione (cas: 5428-09-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.HPLC of Formula: 5428-09-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Functionalisation of isoindolinones via a calcium catalysed Hosomi-Sakurai allylation was written by Basson, Ashley J.;McLaughlin, Mark G.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Category: indole-building-block This article mentions the following:

A rapid and functionally tolerant calcium catalyzed Hosomi-Sakurai reaction has been realized. Employing 1 mol% calcium, allylated isoindolinones I (R¹ = H, C₆H₅, 4-F₃CC₆H₄, thien-2-yl, 1H-benzodioxol-5-yl, etc.; R² = H, Me, allyl, benzyl; R³ = H, CH₃, 4-BrC₆H₄) can be synthesized in high yields and the reaction is shown to be tolerant to a range of medicinally relevant functional groups including heterocycles. The synthetic utility of the reaction has been shown, and a plausible reaction mechanism is provided. In the experiment, the researchers used many compounds, for example, 2-Allylisoindoline-1,3-dione (cas: 5428-09-1Category: indole-building-block).

2-Allylisoindoline-1,3-dione (cas: 5428-09-1) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthesis of Difluoroalkylated Arenes by Hydroaryldifluoromethylation of Alkenes with α,α-Difluoroarylacetic Acids under Photoredox Catalysis was written by Yang, Bin;Xu, Xiu-Hua;Qing, Feng-Ling. And the article was included in Organic Letters in 2016.Category: indole-building-block This article mentions the following:

A visible-light-induced hydroaryldifluoromethylation of alkenes with α,α-difluoroarylacetic acids for preparation of difluoroalkylated arenes has been developed. This reaction proceeds through the hypervalent iodine reagent promoted decarboxylation and subsequent radical hydroaryldifluoromethylation. In the experiment, the researchers used many compounds, for example, 2-Allylisoindoline-1,3-dione (cas: 5428-09-1Category: indole-building-block).

2-Allylisoindoline-1,3-dione (cas: 5428-09-1) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

A flexible route to substituted hydroxy-cyclopentanones from cyclobutanones was written by Heng, Rama;Zard, Samir Z.. And the article was included in Tetrahedron Letters in 2015.Synthetic Route of C11H9NO2 This article mentions the following:

Acetonyl radicals derived from TBS-protected 1-(α-xanthylacetyl)-1-cyclobutanes readily undergo an addition reaction with un-activated alkenes. Deprotection of the resulting adducts with Et₄NF/THF and exposure to silica gel cause ring expansion to give substituted (hydroxy)cyclopentanone derivatives Products of addition to allyl cyanide also underwent β-elimination of the xanthate when treated with Et₄NF/THF. In the experiment, the researchers used many compounds, for example, 2-Allylisoindoline-1,3-dione (cas: 5428-09-1Synthetic Route of C11H9NO2).

2-Allylisoindoline-1,3-dione (cas: 5428-09-1) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Synthetic Route of C11H9NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Copper-Catalyzed Carbotrifluoromethylation of Unactivated Alkenes Driven by Trifluoromethylation of Alkyl Radicals was written by Zhang, Zhenzhen;Zhu, Lin;Li, Chaozhong. And the article was included in Chinese Journal of Chemistry in 2019.Electric Literature of C11H9NO2 This article mentions the following:

Herein an unprecedented protocol for radical carbotrifluoromethylation of unactivated alkenes is reported. With Cu(OTf)₂ as the catalyst, the reaction of unactivated alkenes, TMSCF₃ and activated alkyl chlorides at room temperature provides the corresponding carbotrifluoromethylation products in satisfactory yields. Directed by trifluoromethylation of alkyl radicals, the method exhibits an excellent regioselectivity that is opposite to those driven by CF₃ radical addition In the experiment, the researchers used many compounds, for example, 2-Allylisoindoline-1,3-dione (cas: 5428-09-1Electric Literature of C11H9NO2).

2-Allylisoindoline-1,3-dione (cas: 5428-09-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Electric Literature of C11H9NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthesis of Difluoroalkylated Arenes by Hydroaryldifluoromethylation of Alkenes with α,α-Difluoroarylacetic Acids under Photoredox Catalysis was written by Yang, Bin;Xu, Xiu-Hua;Qing, Feng-Ling. And the article was included in Organic Letters in 2016.Category: indole-building-block This article mentions the following:

A visible-light-induced hydroaryldifluoromethylation of alkenes with α,α-difluoroarylacetic acids for preparation of difluoroalkylated arenes has been developed. This reaction proceeds through the hypervalent iodine reagent promoted decarboxylation and subsequent radical hydroaryldifluoromethylation. In the experiment, the researchers used many compounds, for example, 2-Allylisoindoline-1,3-dione (cas: 5428-09-1Category: indole-building-block).

2-Allylisoindoline-1,3-dione (cas: 5428-09-1) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles