Tag: 187.2

Copper-Catalyzed Intermolecular Trifluoromethylthiocyanation of Alkenes: Convenient Access to CF₃-Containing Alkyl Thiocyanates was written by Liang, Zhaoli;Wang, Fei;Chen, Pinhong;Liu, Guosheng. And the article was included in Organic Letters in 2015.HPLC of Formula: 5428-09-1 This article mentions the following:

A highly selective and efficient approach for the direct trifluoromethylthiocyanation of alkenes has been developed using trimethylsilyl isothiocyanate (TMSNCS) as the thiocyanating agent and Togni reagent as the CF₃ source in the presence of copper(I) catalyst. Both activated and unactivated alkenes work well to deliver various CF₃-containing thiocyanates. In the experiment, the researchers used many compounds, for example, 2-Allylisoindoline-1,3-dione (cas: 5428-09-1HPLC of Formula: 5428-09-1).

2-Allylisoindoline-1,3-dione (cas: 5428-09-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.HPLC of Formula: 5428-09-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Functionalisation of isoindolinones via a calcium catalysed Hosomi-Sakurai allylation was written by Basson, Ashley J.;McLaughlin, Mark G.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Category: indole-building-block This article mentions the following:

A rapid and functionally tolerant calcium catalyzed Hosomi-Sakurai reaction has been realized. Employing 1 mol% calcium, allylated isoindolinones I (R¹ = H, C₆H₅, 4-F₃CC₆H₄, thien-2-yl, 1H-benzodioxol-5-yl, etc.; R² = H, Me, allyl, benzyl; R³ = H, CH₃, 4-BrC₆H₄) can be synthesized in high yields and the reaction is shown to be tolerant to a range of medicinally relevant functional groups including heterocycles. The synthetic utility of the reaction has been shown, and a plausible reaction mechanism is provided. In the experiment, the researchers used many compounds, for example, 2-Allylisoindoline-1,3-dione (cas: 5428-09-1Category: indole-building-block).

2-Allylisoindoline-1,3-dione (cas: 5428-09-1) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles