Tag: 199.57

Jarapula, Ravi et al. published their research in World Journal of Pharmacy and Pharmaceutical Sciences in 2017 | CAS: 84378-94-9

4-Chloro-5-fluoroindoline-2,3-dione (cas: 84378-94-9) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Synthetic Route of C8H3ClFNO2

Synthesis, in vitro anticancer and molecular docking studies of new bisisatins as anticancer agents was written by Jarapula, Ravi;Rekulapally, Sriram;Cidda, Manasa;Manda, Sarangapani. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2017.Synthetic Route of C8H3ClFNO2 This article mentions the following:

Fifteen sym. bis-schiff base of isatin derivatives were synthesized by reaction of succinic acid hydrazide with various isatins and the synthesized compounds were characterized by spectral anal. The substances were further subjected to in vitro cytotoxicity evaluatation against A549 and MCF-7 cell lines with MTT assay. All the synthesized compounds shown significantly inhibited the growth of MCF-7 cells over the A549 cells and the IC50 values of all the compounds were found between 10.24 and 28.65 渭M. The compound 6j has resulted highest cytotoxicity in the entire series studied, in addition 6d, 6c, 6e and 6n were shown to display moderate activity. Further, mol. docking studies of the ligand’s were done on EGFR using GRIP batch docking method. The compounds 6c, 6d, 6e, 6i, 6j and 6l exhibited good docking (PLP) scores with receptor having Hydrogen, Hydrophobic and Vander Waal’s interactions. In the experiment, the researchers used many compounds, for example, 4-Chloro-5-fluoroindoline-2,3-dione (cas: 84378-94-9Synthetic Route of C8H3ClFNO2).

4-Chloro-5-fluoroindoline-2,3-dione (cas: 84378-94-9) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Synthetic Route of C8H3ClFNO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Jarapula, Ravi et al. published their research in World Journal of Pharmacy and Pharmaceutical Sciences in 2017 | CAS: 84378-94-9

4-Chloro-5-fluoroindoline-2,3-dione (cas: 84378-94-9) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Synthetic Route of C8H3ClFNO2

Synthesis, in vitro anticancer and molecular docking studies of new bisisatins as anticancer agents was written by Jarapula, Ravi;Rekulapally, Sriram;Cidda, Manasa;Manda, Sarangapani. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2017.Synthetic Route of C8H3ClFNO2 This article mentions the following:

Fifteen sym. bis-schiff base of isatin derivatives were synthesized by reaction of succinic acid hydrazide with various isatins and the synthesized compounds were characterized by spectral anal. The substances were further subjected to in vitro cytotoxicity evaluatation against A549 and MCF-7 cell lines with MTT assay. All the synthesized compounds shown significantly inhibited the growth of MCF-7 cells over the A549 cells and the IC50 values of all the compounds were found between 10.24 and 28.65 μM. The compound 6j has resulted highest cytotoxicity in the entire series studied, in addition 6d, 6c, 6e and 6n were shown to display moderate activity. Further, mol. docking studies of the ligand’s were done on EGFR using GRIP batch docking method. The compounds 6c, 6d, 6e, 6i, 6j and 6l exhibited good docking (PLP) scores with receptor having Hydrogen, Hydrophobic and Vander Waal’s interactions. In the experiment, the researchers used many compounds, for example, 4-Chloro-5-fluoroindoline-2,3-dione (cas: 84378-94-9Synthetic Route of C8H3ClFNO2).

4-Chloro-5-fluoroindoline-2,3-dione (cas: 84378-94-9) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Synthetic Route of C8H3ClFNO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles