Tag: 202.2524

Metabolism and Metabolites of Dithiocarbamates in the Plant Pathogenic Fungus Leptosphaeria maculans was written by Pedras, M. Soledade C.;Sarma-Mamillapalle, Vijay K.. And the article was included in Journal of Agricultural and Food Chemistry in 2012.Application In Synthesis of N-(2-(1H-Indol-3-yl)ethyl)acetamide This article mentions the following:

Synthetic compounds containing a dithiocarbamate group are known to have a variety of biol. effects and applications including antifungal, herbicidal, and insecticidal application. Leptosphaeria maculans is a fungal pathogen of crucifers able to detoxify efficiently the only plant natural product containing a dithiocarbamate group, the phytoalexin brassinin. To evaluate the effects of dithiocarbamates on L. maculans, a number of structurally diverse S-Me dithiocarbamates containing indolyl, biphenyl, and benzimidazolyl moieties were synthesized, and their antifungal activities and metabolism by L. maculans were investigated. All dithiocarbamates were transformed by L. maculans through hydrolysis to the corresponding amines, which were less antifungal than the parent compounds Two dithiocarbonates were shown to be much less antifungal than the corresponding dithiocarbamates. Results of this investigation indicate that S-Me dithiocarbamates are not useful inhibitors of L. maculans and that their rates of transformation by L. maculans did not correlate with the antifungal activity of the particular compound In the experiment, the researchers used many compounds, for example, N-(2-(1H-Indol-3-yl)ethyl)acetamide (cas: 1016-47-3Application In Synthesis of N-(2-(1H-Indol-3-yl)ethyl)acetamide).

N-(2-(1H-Indol-3-yl)ethyl)acetamide (cas: 1016-47-3) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application In Synthesis of N-(2-(1H-Indol-3-yl)ethyl)acetamide

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Light microscopic autoradiography of rat retinae after intravitreal injection of [³H]6-methoxy-tetrahydro]尾-carboline was written by Leino, Markku;Markkanen, Seppo;Airaksinen, Mauno M.;Gynther, Jukka;Kari, Ilkka. And the article was included in Acta Ophthalmologica in 1984.Application of 20315-68-8 This article mentions the following:

The autoradiog. retinal distribution of intravitreally injected [³H]6-methoxy-tetrahydro-尾-carboline (6-MeO-THBC) in rats was studied. The synaptic and ganglion cell layers accumulate pronounced radioactivity, as do some intra- and extracellular locations in the inner nuclear layer and the outer segments of the photoreceptors. The pigment epithelium gradually accumulates a very dense band of radioactivity. The relation between 6-MeO-THBC, melatonin and other 5-methoxy-indoles is discussed. In the experiment, the researchers used many compounds, for example, 6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (cas: 20315-68-8Application of 20315-68-8).

6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (cas: 20315-68-8) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Application of 20315-68-8

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

A concise and rapid approach to the marine natural product streptochlorin and its analogs was written by Lee, Jong Seok;Shin, Junho;Lee, Hyi-Seung;Shin, Hee Jae;Lee, Yeon-Ju. And the article was included in Bulletin of the Korean Chemical Society in 2013.Quality Control of N-(2-(1H-Indol-3-yl)ethyl)acetamide This article mentions the following:

The synthesis of the target compounds was achieved by a strategy involving a a van Leusen oxazole synthesis and a Gabriel-Robinson reaction (cyclodehydration). The title compounds thus formed included a streptochlorin analog (I) and related substances [3-(4-chloro-5-oxazolyl)-1H-indole, streptochlorin derivatives and analogs]. The synthesis of the target compounds was achieved using 3-formyl-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester derivatives and 1-[(isocyanomethyl)sulfonyl]-4-methylbenzene (TosMIC) as starting materials. In the experiment, the researchers used many compounds, for example, N-(2-(1H-Indol-3-yl)ethyl)acetamide (cas: 1016-47-3Quality Control of N-(2-(1H-Indol-3-yl)ethyl)acetamide).

N-(2-(1H-Indol-3-yl)ethyl)acetamide (cas: 1016-47-3) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Quality Control of N-(2-(1H-Indol-3-yl)ethyl)acetamide

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Effects of 6-methoxytetrahydro-尾-carboline on 5-hydroxytryptamine binding in rat brain was written by Taylor, Dorothy L.;Silverman, Peter B.;Ho, Beng T.. And the article was included in Journal of Pharmacy and Pharmacology in 1984.HPLC of Formula: 20315-68-8 This article mentions the following:

6-Methoxytetraydro-尾-carboline (I) [20315-68-8] competes for 5-HT聽聽[50-67-9] binding sites in rat brain in vitro and in vivo. The 尾-carboline is more active at the type 1, 5-HT, than the type 2, spiperone, receptors in vitro. Following injection into rats, I decreases 5-HT but not spiperone binding to the brain cortex. The ineffectiveness of I on spiperone binding in vivo corresponds with the results obtained in vitro. Thus, the effect of I on central 5-HT binding may be a significant aspect of its 5-hydroxytryptaminergic activity. In the experiment, the researchers used many compounds, for example, 6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (cas: 20315-68-8HPLC of Formula: 20315-68-8).

6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (cas: 20315-68-8) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.HPLC of Formula: 20315-68-8

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Study on secondary metabolite of Trachelospermum jasminoides endophyte Myrothecium roridum (IFB-E009) was written by Wang, Wei;Jiang, Rong. And the article was included in Anhui Nongye Kexue in 2012.Synthetic Route of C12H14N2O This article mentions the following:

Eight compounds were isolated and identified from liquid fermentation products of Myrothecium roridum (IFB-E009) in Trachelospermum jasminoides, 1-4 were trichothecenes compounds, 5-6 were amides compounds, 7 was cyclic peptide, and 8 was uracil. As indicated by activity test, compound 1,4 showed activities to the human colon cancer cells SW1116. IC₅₀ were 25.68 and 38.93 渭mol/L, while the IC₅₀ of adriamycin was 5.31 渭mol. The study would provide theory and practice basis for the development and utilization of endophytes in pharmaceutical plants. In the experiment, the researchers used many compounds, for example, N-(2-(1H-Indol-3-yl)ethyl)acetamide (cas: 1016-47-3Synthetic Route of C12H14N2O).

N-(2-(1H-Indol-3-yl)ethyl)acetamide (cas: 1016-47-3) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Synthetic Route of C12H14N2O

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Discovery of tetrahydro-尾-carboline- and indole-based derivatives as promising phosphodiesterase-4 inhibitors: Synthesis, biological evaluation, and molecular modeling studies was written by Darwish, Khaled M.;Abdelwaly, Ahmad;Atta, Asmaa M.;Helal, Mohamed A.. And the article was included in Journal of Molecular Structure in 2022.Application In Synthesis of 6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole This article mentions the following:

Phosphodiesterase-4 (PDE4) is responsible for the selective degradation of the 3′-cyclic phosphate bonds of cAMP. A collection of twenty-three diverse 1,2,3,4-tertahydro-尾-carboline- and indole-based analogs were synthesized and assessed for their inhibitory activity against human PDE4. The compounds were prepared using straightforward procedures and characterized using ¹H- and ¹³C NMR, IR, and mass spectroscopy as well as elemental anal. Fifteen of the prepared compounds exhibited significant inhibitory activity with IC₅₀ values in the lower micromolar to upper nanomolar ranges. The most active compounds also showed good selectivity for PDE4 over the related enzyme family member, PDE5, with either insignificant or null% inhibition of the latter enzyme. The indole-based compounds, 21b (I) and 21c (II), showed the most pronounced PDE4 inhibition with IC₅₀ values of 754 and 664 nM, resp. The PDE4B active site comprises both hydrophobic and solvent-filled pockets. The hydrophobic pocket (Q) includes the invariant purine-selective Gln443 which is critical for cAMP. Below this Gln443 lies Phe446 which acts as a hydrophobic P-clamp stabilizing the ligand aromatic ring system. Mol. docking investigation showed preferential anchoring of the active compounds within the PDE4 active site through interactions between the indole nitrogens and the dimethoxy Ph groups with key residues. Overall, the prepared compounds are novel and simple mols. with good potential for future optimization. Showing satisfactory predicted ADME/safety and drug-likeness properties, compound 21c is considered a promising lead for further optimization towards clin. investigation against inflammatory, auto-immune diseases, or certain types of cancer. In the experiment, the researchers used many compounds, for example, 6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (cas: 20315-68-8Application In Synthesis of 6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole).

6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (cas: 20315-68-8) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Application In Synthesis of 6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles