Tag: 203.1941

Zhang, Han-Cheng et al. published their research in Journal of Medicinal Chemistry in 2005 | CAS: 18372-22-0

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Recommanded Product: 18372-22-0

Novel Indolylindazolylmaleimides as Inhibitors of Protein Kinase C-尾: Synthesis, Biological Activity, and Cardiovascular Safety was written by Zhang, Han-Cheng;Derian, Claudia K.;McComsey, David F.;White, Kimberly B.;Ye, Hong;Hecker, Leonard R.;Li, Jian;Addo, Michael F.;Croll, Diane;Eckardt, Annette J.;Smith, Charles E.;Li, Quan;Cheung, Wai-Man;Conway, Bruce R.;Emanuel, Stuart;Demarest, Keith T.;Andrade-Gordon, Patricia;Damiano, Bruce P.;Maryanoff, Bruce E.. And the article was included in Journal of Medicinal Chemistry in 2005.Recommanded Product: 18372-22-0 This article mentions the following:

Novel indolylindazolylmaleimides were synthesized and examined for kinase inhibition. Low-nanomolar inhibitors of PKC-尾 with good to excellent selectivity vs other PKC isoenzymes and GSK-3尾 were identified. In a cell-based functional assay, the title compounds I [R = 2-naphthyl, 3-quinolinyl] effectively blocked IL-8 release induced by PKC-尾II (IC50 = 20-25 nM). In cardiovascular safety assessment, representative lead compounds bound to the hERG channel with high affinity, potently inhibited ion current in a patch-clamp experiment, and caused a dose-dependent increase of QTc in guinea pigs. In the experiment, the researchers used many compounds, for example, Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0Recommanded Product: 18372-22-0).

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Recommanded Product: 18372-22-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Garg, Neil K. et al. published their research in Tetrahedron Letters in 2005 | CAS: 18372-22-0

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). COA of Formula: C11H9NO3

Synthesis of bis(indole)-1,2,4-triazinones was written by Garg, Neil K.;Stoltz, Brian M.. And the article was included in Tetrahedron Letters in 2005.COA of Formula: C11H9NO3 This article mentions the following:

A facile method for the synthesis of meta- and para-substituted bis(indole)-1,2,4-triazinones, e.g., I, is presented. To access these triazinones, a cyclocondensation reaction between amidrazone and ketoester functionalities was applied. The structures of these interesting compounds were established unambiguously by X-ray crystallog. In the experiment, the researchers used many compounds, for example, Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0COA of Formula: C11H9NO3).

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). COA of Formula: C11H9NO3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wang, Min et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2011 | CAS: 18372-22-0

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Recommanded Product: 18372-22-0

[11C]enzastaurin, the first design and radiosynthesis of a new potential PET agent for imaging of protein kinase C was written by Wang, Min;Xu, Lu;Gao, Mingzhang;Miller, Kathy D.;Sledge, George W.;Zheng, Qi-Huang. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Recommanded Product: 18372-22-0 This article mentions the following:

Enzastaurin (LY317615) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 value of 鈭? nM. [11C]Enzastaurin (3-(1-[11C]methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione), I a new potential PET agent for imaging of PKC, was first designed and synthesized in 20-25% decay corrected radiochem. yield and 370-555 GBq/渭mol specific activity at end of bombardment (EOB). The synthetic strategy was to prepare a carbon-11-labeled maleic anhydride intermediate followed by the conversion to maleimide. In the experiment, the researchers used many compounds, for example, Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0Recommanded Product: 18372-22-0).

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Recommanded Product: 18372-22-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Moorhouse, Adam D. et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2011 | CAS: 18372-22-0

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate

Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5 was written by Moorhouse, Adam D.;Spiteri, Christian;Sharma, Pallavi;Zloh, Mire;Moses, John E.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2011.Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate This article mentions the following:

HLDH-5 has emerged as a promising target for anti-glycolytic cancer chemotherapy. Here we report a first generation of bifunctional inhibitors, which show promising activity against hLDH-5. In the experiment, the researchers used many compounds, for example, Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate).

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Grunwald, Claus et al. published their research in Analytical Biochemistry in 1967 | CAS: 18372-22-0

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Recommanded Product: Methyl 2-(1H-indol-3-yl)-2-oxoacetate

Gas and other chromatographic separations of indolic methyl esters was written by Grunwald, Claus;Vendrell, Miguel;Stowe, Bruce B.. And the article was included in Analytical Biochemistry in 1967.Recommanded Product: Methyl 2-(1H-indol-3-yl)-2-oxoacetate This article mentions the following:

All tested acidic indoles were esterified by diazomethylation without appreciable loss. A group of 10 Me ester derivatives were obtained in crystalline form. These were used to test the relative values of 4 gas chromatographic substrates. Quant. comparisons led to the selection of Versamid 900, HI-EFF 8 BP, and SE-30 as permitting complete separation of all indole esters, while SE-52 was unsatisfactory. Gradient elution column and thin-layer chromatog. as pre- and post-purification techniques for these indole esters were also compared, as was the usefulness of uv spectroscopy and spectrophotofluorometry in acidic indole anal. 20 references. In the experiment, the researchers used many compounds, for example, Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0Recommanded Product: Methyl 2-(1H-indol-3-yl)-2-oxoacetate).

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Recommanded Product: Methyl 2-(1H-indol-3-yl)-2-oxoacetate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Longeon, Arlette et al. published their research in Marine Drugs in 2011 | CAS: 18372-22-0

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate

Bioactive indole derivatives from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp was written by Longeon, Arlette;Copp, Brent R.;Quevrain, Elodie;Roue, Melanie;Kientz, Betty;Cresteil, Thierry;Petek, Sylvain;Debitus, Cecile;Bourguet-Kondracki, Marie-Lise. And the article was included in Marine Drugs in 2011.Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate This article mentions the following:

Indole derivatives including bromoindoles were isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through anal. of mass spectra and 1- and 2-dimensional NMR spectroscopic data. Their potential inhibitory phospholipase A2 (PLA2), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-L-hypaphorine (I) isolated from Hyrtios sp. revealed a weak bee venom PLA2 inhibition (IC50 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol, also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29. In the experiment, the researchers used many compounds, for example, Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate).

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Garg, Neil K. et al. published their research in Tetrahedron Letters in 2005 | CAS: 18372-22-0

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). COA of Formula: C11H9NO3

Synthesis of bis(indole)-1,2,4-triazinones was written by Garg, Neil K.;Stoltz, Brian M.. And the article was included in Tetrahedron Letters in 2005.COA of Formula: C11H9NO3 This article mentions the following:

A facile method for the synthesis of meta- and para-substituted bis(indole)-1,2,4-triazinones, e.g., I, is presented. To access these triazinones, a cyclocondensation reaction between amidrazone and ketoester functionalities was applied. The structures of these interesting compounds were established unambiguously by X-ray crystallog. In the experiment, the researchers used many compounds, for example, Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0COA of Formula: C11H9NO3).

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). COA of Formula: C11H9NO3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wang, Min et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2011 | CAS: 18372-22-0

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Recommanded Product: 18372-22-0

[11C]enzastaurin, the first design and radiosynthesis of a new potential PET agent for imaging of protein kinase C was written by Wang, Min;Xu, Lu;Gao, Mingzhang;Miller, Kathy D.;Sledge, George W.;Zheng, Qi-Huang. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Recommanded Product: 18372-22-0 This article mentions the following:

Enzastaurin (LY317615) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 value of ∼6 nM. [11C]Enzastaurin (3-(1-[11C]methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione), I a new potential PET agent for imaging of PKC, was first designed and synthesized in 20-25% decay corrected radiochem. yield and 370-555 GBq/μmol specific activity at end of bombardment (EOB). The synthetic strategy was to prepare a carbon-11-labeled maleic anhydride intermediate followed by the conversion to maleimide. In the experiment, the researchers used many compounds, for example, Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0Recommanded Product: 18372-22-0).

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Recommanded Product: 18372-22-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Moorhouse, Adam D. et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2011 | CAS: 18372-22-0

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate

Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5 was written by Moorhouse, Adam D.;Spiteri, Christian;Sharma, Pallavi;Zloh, Mire;Moses, John E.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2011.Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate This article mentions the following:

HLDH-5 has emerged as a promising target for anti-glycolytic cancer chemotherapy. Here we report a first generation of bifunctional inhibitors, which show promising activity against hLDH-5. In the experiment, the researchers used many compounds, for example, Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate).

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Safety of Methyl 2-(1H-indol-3-yl)-2-oxoacetate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Grunwald, Claus et al. published their research in Analytical Biochemistry in 1967 | CAS: 18372-22-0

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Recommanded Product: Methyl 2-(1H-indol-3-yl)-2-oxoacetate

Gas and other chromatographic separations of indolic methyl esters was written by Grunwald, Claus;Vendrell, Miguel;Stowe, Bruce B.. And the article was included in Analytical Biochemistry in 1967.Recommanded Product: Methyl 2-(1H-indol-3-yl)-2-oxoacetate This article mentions the following:

All tested acidic indoles were esterified by diazomethylation without appreciable loss. A group of 10 Me ester derivatives were obtained in crystalline form. These were used to test the relative values of 4 gas chromatographic substrates. Quant. comparisons led to the selection of Versamid 900, HI-EFF 8 BP, and SE-30 as permitting complete separation of all indole esters, while SE-52 was unsatisfactory. Gradient elution column and thin-layer chromatog. as pre- and post-purification techniques for these indole esters were also compared, as was the usefulness of uv spectroscopy and spectrophotofluorometry in acidic indole anal. 20 references. In the experiment, the researchers used many compounds, for example, Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0Recommanded Product: Methyl 2-(1H-indol-3-yl)-2-oxoacetate).

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Recommanded Product: Methyl 2-(1H-indol-3-yl)-2-oxoacetate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles