Tag: 204.2252

Chirality detection by Raman spectroscopy: The case of enantioselective interactions between amino acids and polymer-modified chiral silica was written by Kong, Huanjun;Sun, Xueping;Yang, Liu;Liu, Xinling;Yang, Haifeng;Jin, Ren-Hua. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2020.HPLC of Formula: 153-94-6 This article mentions the following:

In chirality research area, it is of interest to reveal the chiral feature of inorganic nanomaterials and their enantioselective interactions with biomols. Although common Raman spectroscopy is not regarded as a direct chirality anal. tool, it is in fact effective and sensitive to study the enantioselectivity phenomena, which is demonstrated by the enantio-discrimination of amino acid enantiomers using the polydopamine-modified intrinsically chiral SiO₂ nanofibers in this work. The Raman scattering intensities of an enantiomer of cysteine are more than twice as high as those of the other enantiomer with opposite handedness. Similar results were also found in the cases of cystine, phenylalanine, and tryptophan enantiomers. In turn, these organic mols. could be used as chirality indicators for SiO₂, which was clarified by the unique Raman spectra-derived mirror-image relationships. Thus, an indirect chirality detection method for inorganic nanomaterials was developed. In the experiment, the researchers used many compounds, for example, H-D-Trp-OH (cas: 153-94-6HPLC of Formula: 153-94-6).

H-D-Trp-OH (cas: 153-94-6) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.HPLC of Formula: 153-94-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Molecular mechanism of Gleditsiae Spina for the treatment of high-grade serous ovarian cancer based on network pharmacology and pharmacological experiments was written by Zhang, Boran;Dan, Wenchao;Zhang, Ganlin;Wang, Xiaomin. And the article was included in BioMed Research International in 2022.Computed Properties of C11H12N2O2 This article mentions the following:

Gleditsiae Spina, widely used in traditional Chinese medicine, has a good curative effect on malignant tumors such as ovarian cancer, but the mechanism is not clear. So, we aimed to analyze the pharmacol. mechanism of Gleditsiae Spina in the treatment of high-grade serous ovarian cancer (HGSC) based on network pharmacol. and biol. experiments The main active ingredients of Gleditsiae Spina were identified by high performance liquid chromatog. (HPLC) and mass spectrometry (MS), and the active ingredients were performed by ADME screening. The component targets of Gleditsiae Spina were screened using the PharmMapper platform, and differentially expressed genes in normal and HGSC tissues were identified through the GEO database. Thereafter, the network of “active ingredient-targets” was constructed by cytoscape 3.7.2 software. The protein-protein interaction network was established by the BioGenet database to mine the potential protein function. Biol. processes and pathways were analyzed through Gene Ontol. and Kyoto Encyclopedia of Genes and Genomes anal. The binding ability of the core components of the Gleditsiae Spina and the core target of HGSC was verified by mol. docking and mol. dynamics simulation, and the therapeutic effect of Gleditsiae Spina was proved in vitro through cytotoxicity experiments The effect of Gleditsiae Spina on the core pathway is obtained by western blotting. Gleditsiae Spina had cytotoxicity on HGSC based on network pharmacol. and biol. experiments Luteolin, genistein, D-(+)-tryptophan, ursolic acid, and berberine are the identified core active ingredients of Gleditsiae Spina for regulating HGSC, with HPSE, PI3KCA, AKT1, and CTNNB1as the ideal targets. The prediction results were verified by mol. docking, mol. dynamic simulation, cell viability, and western blot anal. Gleditsiae Spina mainly downregulates the expression of heparanase and β-catenin to affect the composition of tumor cytoplasmic matrix and can regulate the PI3K-AKT pathway, integrating multiple targets and multiple pathways to play a therapeutic role. It also provides a theor. basis for the prevention of ovarian cancer and its treatment using traditional Chinese medicine in the future. In the experiment, the researchers used many compounds, for example, H-D-Trp-OH (cas: 153-94-6Computed Properties of C11H12N2O2).

H-D-Trp-OH (cas: 153-94-6) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Computed Properties of C11H12N2O2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chiral Protein-Covalent Organic Framework 3D-Printed Structures as Chiral Biosensors was written by Wang, Lujun;Gao, Wanli;Ng, Siowwoon;Pumera, Martin. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2021.Electric Literature of C11H12N2O2 This article mentions the following:

Three-dimensional (3D) printing technol. has attracted great attention for prototyping different electrochem. sensor devices. However, chiral recognition remains a crucial challenge for electrochem. sensors with similar physicochem. properties such as enantiomers. In this work, a magnetic covalent organic framework (COF) and bovine serum albumin (BSA) (as the chiral surface) functionalized 3D-printed electrochem. chiral sensor is reported for the first time. The characterization of the chiral biomol.-COF 3D-printed constructure was performed by SEM (SEM), XPS, and energy-dispersive X-ray spectroscopy (EDX). A tryptophan (Trp) enantiomer was chosen as the model chiral mol. to estimate the chiral recognition ability of the magnetic COF and BSA-based 3DE (Fe₃O₄@COF@BSA/3DE). We have demonstrated that the Fe₃O₄@COF@BSA/3DE exhibited excellent chiral recognition to L-Trp as compared to D-Trp. The chiral protein-COF sensing interface was used to determine the concentration of L-Trp in a racemic mixture of D-Trp and L-Trp. This strategy of on-demand fabrication of 3D-printed protein-COF-modified electrodes opens up new approaches for enantiomer recognition. In the experiment, the researchers used many compounds, for example, H-D-Trp-OH (cas: 153-94-6Electric Literature of C11H12N2O2).

H-D-Trp-OH (cas: 153-94-6) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Electric Literature of C11H12N2O2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Effect of Hong Qu on the flavor and quality of Hakka yellow rice wine (Huangjiu) produced in Southern China was written by Zhao, Wenhong;Qian, Min;Dong, Hao;Liu, Xiaoyan;Bai, Weidong;Liu, Gongliang;Lv, Xu-cong. And the article was included in LWT–Food Science and Technology in 2022.Electric Literature of C11H12N2O2 This article mentions the following:

This study aimed to investigate effect of Hong Qu on flavor and quality of Hakka yellow rice wine (Hakka Huangjiu). Volatile components of three kinds of Hakka Huangjiu with or without adding Hong Qu were analyzed by solid phase microextraction-gas chromatog.-mass spectrometry. Their non-volatile components were also detected by liquid chromatog. quadrupole Orbitrap mass spectrometry (LC-Q-Orbitrap-MS). Results indicated that there were great differences in flavor components among three wines. Among them, the main difference components between traditional Hakka Huangjiu and Hakka Huangjiu without adding Hong Qu were isoamyl alc., phenylethanol, iso-Bu acetate, iso-Bu alc., Et palmitate and Et decanoate. In Hakka Huangjiu, esters were the most volatile components, followed by alcs., while acids were less. Under NEG and POS modes of LC-Q-Orbitrap-MS, a total of 765 and 1244 components were detected in three kinds of Hakka Huangjiu, resp. Among 217 kinds of polypeptides detected, the content of 160 kinds of polypeptides in Hakka Huangjiu adding only with Hong Qu was higher than that of traditional Hakka Huangjiu and Hakka Huangjiu without adding Hong Qu. Amino acids and polypeptides contents in Hakka Huangjiu brewed only with Hong Qu and traditional Hakka Huangjiu co-fermented with Hong Qu were relatively high. In the experiment, the researchers used many compounds, for example, H-D-Trp-OH (cas: 153-94-6Electric Literature of C11H12N2O2).

H-D-Trp-OH (cas: 153-94-6) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Electric Literature of C11H12N2O2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chirality detection by Raman spectroscopy: The case of enantioselective interactions between amino acids and polymer-modified chiral silica was written by Kong, Huanjun;Sun, Xueping;Yang, Liu;Liu, Xinling;Yang, Haifeng;Jin, Ren-Hua. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2020.HPLC of Formula: 153-94-6 This article mentions the following:

In chirality research area, it is of interest to reveal the chiral feature of inorganic nanomaterials and their enantioselective interactions with biomols. Although common Raman spectroscopy is not regarded as a direct chirality anal. tool, it is in fact effective and sensitive to study the enantioselectivity phenomena, which is demonstrated by the enantio-discrimination of amino acid enantiomers using the polydopamine-modified intrinsically chiral SiO₂ nanofibers in this work. The Raman scattering intensities of an enantiomer of cysteine are more than twice as high as those of the other enantiomer with opposite handedness. Similar results were also found in the cases of cystine, phenylalanine, and tryptophan enantiomers. In turn, these organic mols. could be used as chirality indicators for SiO₂, which was clarified by the unique Raman spectra-derived mirror-image relationships. Thus, an indirect chirality detection method for inorganic nanomaterials was developed. In the experiment, the researchers used many compounds, for example, H-D-Trp-OH (cas: 153-94-6HPLC of Formula: 153-94-6).

H-D-Trp-OH (cas: 153-94-6) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.HPLC of Formula: 153-94-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Molecular mechanism of Gleditsiae Spina for the treatment of high-grade serous ovarian cancer based on network pharmacology and pharmacological experiments was written by Zhang, Boran;Dan, Wenchao;Zhang, Ganlin;Wang, Xiaomin. And the article was included in BioMed Research International in 2022.Computed Properties of C11H12N2O2 This article mentions the following:

Gleditsiae Spina, widely used in traditional Chinese medicine, has a good curative effect on malignant tumors such as ovarian cancer, but the mechanism is not clear. So, we aimed to analyze the pharmacol. mechanism of Gleditsiae Spina in the treatment of high-grade serous ovarian cancer (HGSC) based on network pharmacol. and biol. experiments The main active ingredients of Gleditsiae Spina were identified by high performance liquid chromatog. (HPLC) and mass spectrometry (MS), and the active ingredients were performed by ADME screening. The component targets of Gleditsiae Spina were screened using the PharmMapper platform, and differentially expressed genes in normal and HGSC tissues were identified through the GEO database. Thereafter, the network of “active ingredient-targets” was constructed by cytoscape 3.7.2 software. The protein-protein interaction network was established by the BioGenet database to mine the potential protein function. Biol. processes and pathways were analyzed through Gene Ontol. and Kyoto Encyclopedia of Genes and Genomes anal. The binding ability of the core components of the Gleditsiae Spina and the core target of HGSC was verified by mol. docking and mol. dynamics simulation, and the therapeutic effect of Gleditsiae Spina was proved in vitro through cytotoxicity experiments The effect of Gleditsiae Spina on the core pathway is obtained by western blotting. Gleditsiae Spina had cytotoxicity on HGSC based on network pharmacol. and biol. experiments Luteolin, genistein, D-(+)-tryptophan, ursolic acid, and berberine are the identified core active ingredients of Gleditsiae Spina for regulating HGSC, with HPSE, PI3KCA, AKT1, and CTNNB1as the ideal targets. The prediction results were verified by mol. docking, mol. dynamic simulation, cell viability, and western blot anal. Gleditsiae Spina mainly downregulates the expression of heparanase and β-catenin to affect the composition of tumor cytoplasmic matrix and can regulate the PI3K-AKT pathway, integrating multiple targets and multiple pathways to play a therapeutic role. It also provides a theor. basis for the prevention of ovarian cancer and its treatment using traditional Chinese medicine in the future. In the experiment, the researchers used many compounds, for example, H-D-Trp-OH (cas: 153-94-6Computed Properties of C11H12N2O2).

H-D-Trp-OH (cas: 153-94-6) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Computed Properties of C11H12N2O2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles