Tag: 210.0705

Xu, Ze-Feng et al. published their research in Organic Chemistry Frontiers in 2019 | CAS: 590417-55-3

4-Bromo-1-methyl-1H-indole (cas: 590417-55-3) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Computed Properties of C9H8BrN

Synthesis of 伪-aminoketones from N-sulfonyl-1,2,3-triazoles via N-sulfinyl imines generated by intramolecular oxygen transfer was written by Xu, Ze-Feng;Shan, Lihong;Zhang, Wan;Cen, Mengjie;Li, Chuan-Ying. And the article was included in Organic Chemistry Frontiers in 2019.Computed Properties of C9H8BrN This article mentions the following:

A general procedure for intramol. oxygen transfer from sulfonyl to a carbenoid carbon was established, extending the reaction mode of the corresponding common N-sulfonyl-1,2,3-triazoles. Indoles, and some other arenes, were employed as nucleophiles to react with the resulting key N-sulfinyl imine intermediate, and valuable 伪-aminoketones could be synthesized conveniently. The synthetic utility of the products was further exhibited by convenient synthesis of gem-diaryl ketones and densely substituted pyrrole. A tentative reaction mechanism was proposed according to control experiments In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-indole (cas: 590417-55-3Computed Properties of C9H8BrN).

4-Bromo-1-methyl-1H-indole (cas: 590417-55-3) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Computed Properties of C9H8BrN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Shima, Masato et al. published their research in Heterocycles in 2015 | CAS: 590417-55-3

4-Bromo-1-methyl-1H-indole (cas: 590417-55-3) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Synthetic Route of C9H8BrN

Synthetic studies toward welwitindolinone alkaloids. Tandem aldol-michael reaction to form the carbocyclic core of welwitindolinones was written by Shima, Masato;Toyota, Masahiro. And the article was included in Heterocycles in 2015.Synthetic Route of C9H8BrN This article mentions the following:

A tandem aldol-Michael reaction of silyl enol ether of indolylcyclohexanone with acetone to effectively construct a bridged ketone, which is the carbocyclic core of the welwitindolinone family. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-indole (cas: 590417-55-3Synthetic Route of C9H8BrN).

4-Bromo-1-methyl-1H-indole (cas: 590417-55-3) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Synthetic Route of C9H8BrN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Xu, Dekang et al. published their research in Organic Letters in 2019 | CAS: 590417-55-3

4-Bromo-1-methyl-1H-indole (cas: 590417-55-3) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Electric Literature of C9H8BrN

Manipulation of Water for Diversified Functionalization of Tetrahydro-尾-carbolines (TH尾Cs) with Indoles was written by Xu, Dekang;Ye, Fu;Ye, Jinxiang;Gao, Yu;Chen, Haijun. And the article was included in Organic Letters in 2019.Electric Literature of C9H8BrN This article mentions the following:

Water plays a crucial role in organic synthesis. However, diversified functionalization manipulated by water is still rare and remains unexplored. Herein, we report the first water-manipulated protocol to achieve the diversified functionalization of tetrahydro-尾-carbolines (TH尾Cs) in an open flask at room temperature that exhibit a broad functional-group tolerance. More water leads to monoarylation, while less water leads to diarylation. Further one-step transformation afforded oxidized bis(indolyl)methanes, eudistomin U, and the related derivatives in satisfactory yields. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-indole (cas: 590417-55-3Electric Literature of C9H8BrN).

4-Bromo-1-methyl-1H-indole (cas: 590417-55-3) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Electric Literature of C9H8BrN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Ohno, Hiroaki et al. published their research in Chemistry – A European Journal in 2005 | CAS: 590417-55-3

4-Bromo-1-methyl-1H-indole (cas: 590417-55-3) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Application of 590417-55-3

Palladium(0)-catalyzed tandem cyclization of allenenes: Direct construction of tricyclic heterocycles through aromatic C-H activation was written by Ohno, Hiroaki;Miyamura, Kumiko;Mizutani, Tsuyoshi;Kadoh, Yoichi;Takeoka, Yusuke;Hamaguchi, Hisao;Tanaka, Tetsuaki. And the article was included in Chemistry – A European Journal in 2005.Application of 590417-55-3 This article mentions the following:

Palladium(0)-catalyzed tandem cyclization of allenenes is described. Treatment of allenenes, e.g. I [R1 = Me2CH, Me2CHCH2, (S)-EtCHMe, Me3C, PhCH2; R2 = Me3CO2C, 2,4,6-Me3C6H2SO2], with an aryl halide R3I (R3 = Ph, 4-MeC6H4, 4-MeOC6H4, 2-MeOC6H4, 3-MeOC6H4), potassium carbonate, and catalytic Pd(PPh3)4 in dioxane afforded tri- or tetracyclic heterocycles, e.g. II (R4 = H, Me, MeO), in moderate to good yields through insertion of arylpalladium(II) halide into the allenic moiety, intramol. carbopalladation, and aromatic C-H bond activation. The substituent on the olefin terminus has proven to be essential for the success of the tandem cyclization. The reaction with heterocyclic aryl halides such as iodopyrazine or 4-bromo-1-methylindole afforded tri- or tetracyclic heteroaromatic products, e.g. III from iodopyrazine, in good yields. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-indole (cas: 590417-55-3Application of 590417-55-3).

4-Bromo-1-methyl-1H-indole (cas: 590417-55-3) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Application of 590417-55-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Xu, Dekang et al. published their research in Organic Letters in 2019 | CAS: 590417-55-3

4-Bromo-1-methyl-1H-indole (cas: 590417-55-3) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Electric Literature of C9H8BrN

Manipulation of Water for Diversified Functionalization of Tetrahydro-β-carbolines (THβCs) with Indoles was written by Xu, Dekang;Ye, Fu;Ye, Jinxiang;Gao, Yu;Chen, Haijun. And the article was included in Organic Letters in 2019.Electric Literature of C9H8BrN This article mentions the following:

Water plays a crucial role in organic synthesis. However, diversified functionalization manipulated by water is still rare and remains unexplored. Herein, we report the first water-manipulated protocol to achieve the diversified functionalization of tetrahydro-β-carbolines (THβCs) in an open flask at room temperature that exhibit a broad functional-group tolerance. More water leads to monoarylation, while less water leads to diarylation. Further one-step transformation afforded oxidized bis(indolyl)methanes, eudistomin U, and the related derivatives in satisfactory yields. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-indole (cas: 590417-55-3Electric Literature of C9H8BrN).

4-Bromo-1-methyl-1H-indole (cas: 590417-55-3) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Electric Literature of C9H8BrN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Ohno, Hiroaki et al. published their research in Chemistry – A European Journal in 2005 | CAS: 590417-55-3

4-Bromo-1-methyl-1H-indole (cas: 590417-55-3) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Application of 590417-55-3

Palladium(0)-catalyzed tandem cyclization of allenenes: Direct construction of tricyclic heterocycles through aromatic C-H activation was written by Ohno, Hiroaki;Miyamura, Kumiko;Mizutani, Tsuyoshi;Kadoh, Yoichi;Takeoka, Yusuke;Hamaguchi, Hisao;Tanaka, Tetsuaki. And the article was included in Chemistry – A European Journal in 2005.Application of 590417-55-3 This article mentions the following:

Palladium(0)-catalyzed tandem cyclization of allenenes is described. Treatment of allenenes, e.g. I [R1 = Me2CH, Me2CHCH2, (S)-EtCHMe, Me3C, PhCH2; R2 = Me3CO2C, 2,4,6-Me3C6H2SO2], with an aryl halide R3I (R3 = Ph, 4-MeC6H4, 4-MeOC6H4, 2-MeOC6H4, 3-MeOC6H4), potassium carbonate, and catalytic Pd(PPh3)4 in dioxane afforded tri- or tetracyclic heterocycles, e.g. II (R4 = H, Me, MeO), in moderate to good yields through insertion of arylpalladium(II) halide into the allenic moiety, intramol. carbopalladation, and aromatic C-H bond activation. The substituent on the olefin terminus has proven to be essential for the success of the tandem cyclization. The reaction with heterocyclic aryl halides such as iodopyrazine or 4-bromo-1-methylindole afforded tri- or tetracyclic heteroaromatic products, e.g. III from iodopyrazine, in good yields. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-indole (cas: 590417-55-3Application of 590417-55-3).

4-Bromo-1-methyl-1H-indole (cas: 590417-55-3) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Application of 590417-55-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Ohno, Hiroaki et al. published their research in Chemistry – A European Journal in 2005 | CAS: 590417-55-3

4-Bromo-1-methyl-1H-indole (cas: 590417-55-3) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Application of 590417-55-3

Palladium(0)-catalyzed tandem cyclization of allenenes: Direct construction of tricyclic heterocycles through aromatic C-H activation was written by Ohno, Hiroaki;Miyamura, Kumiko;Mizutani, Tsuyoshi;Kadoh, Yoichi;Takeoka, Yusuke;Hamaguchi, Hisao;Tanaka, Tetsuaki. And the article was included in Chemistry – A European Journal in 2005.Application of 590417-55-3 This article mentions the following:

Palladium(0)-catalyzed tandem cyclization of allenenes is described. Treatment of allenenes, e.g. I [R1 = Me2CH, Me2CHCH2, (S)-EtCHMe, Me3C, PhCH2; R2 = Me3CO2C, 2,4,6-Me3C6H2SO2], with an aryl halide R3I (R3 = Ph, 4-MeC6H4, 4-MeOC6H4, 2-MeOC6H4, 3-MeOC6H4), potassium carbonate, and catalytic Pd(PPh3)4 in dioxane afforded tri- or tetracyclic heterocycles, e.g. II (R4 = H, Me, MeO), in moderate to good yields through insertion of arylpalladium(II) halide into the allenic moiety, intramol. carbopalladation, and aromatic C-H bond activation. The substituent on the olefin terminus has proven to be essential for the success of the tandem cyclization. The reaction with heterocyclic aryl halides such as iodopyrazine or 4-bromo-1-methylindole afforded tri- or tetracyclic heteroaromatic products, e.g. III from iodopyrazine, in good yields. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-indole (cas: 590417-55-3Application of 590417-55-3).

4-Bromo-1-methyl-1H-indole (cas: 590417-55-3) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Application of 590417-55-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles