Tag: 221352-46-1

221352-46-1, 2-(tert-Butoxycarbonyl)isoindoline-1-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1. Pyrrolidine (55 mg, 0.7 mmol) was added to a solution of Boc(R,S)-1,3-dihydro-2H-isoindole carboxylic acid (150 mg, 0.55 mmole), diisopropylethyl amine (0.5 ml, 2.8 mmol), and HATU (240 mg, 0.6 mmol) in 5 mL of DMF under a nitrogen atmosphere. The reaction was allowed to stir at room temperature for 12 hours. Saturated NaHCO3 (15 mL) was added to the reaction mixture to quench the reaction. EtOAc (2 x 50 mL) was then EPO added to extract the aqueous solution. Dry EtOAc layer over Na2SO4. The Na2SO4 was filtered off and the filtrated was evaporated to give a brown oil residue. This compound (tert-butyl 1-(pyrrolidine-1-carbonyl)isoindoline-2-carboxylate) was used for the next step reaction without further purification.

221352-46-1, As the paragraph descriping shows that 221352-46-1 is playing an increasingly important role.

Reference£º
Patent; PFIZER PRODUCTS INC.; WO2008/53319; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.221352-46-1,2-(tert-Butoxycarbonyl)isoindoline-1-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of 2,3-dihydro-isoindole-1,2-dicarboxylic acid 2-tert-butyl ester (344 mg, CAS 221352-46-1), 1-(4-amino-3-fluoro-phenyl)-1H-pyridin-2-one (265 mg; CAS 536747-52-1) and DIPEA (0.34 ml) in 10 ml acetonitrile and 1 ml DMF was added BOP-Cl (382 mg). The reaction mixture was stirred for 24 hrs at rt, diluted with AcOEt and washed with 1M HCl, 1M NaOH and brine. The organic layers were dried over magnesium sulfate, evaporated and purified by chromatography (silica gel; AcOEt) to deliver the title compound as a yellow oil (280 mg). MS: 450.4 (M+H)+., 221352-46-1

The synthetic route of 221352-46-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Boehringer, Markus; Zbinden, Katrin Groebke; Haap, Wolfgang; Panday, Narendra; Ricklin, Fabienne; Stahl, Martin; Schmitz, Petra; US2007/112012; (2007); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles