Tag: 226.0269

Catalyst-free synthesis of 伪¹-oxindole-伪-hydroxyphosphonates via phospha-aldol reaction of isatins employing N-heterocyclic phosphine (NHP)-thiourea was written by Molleti, Nagaraju;Yong Kang, Jun. And the article was included in Organic & Biomolecular Chemistry in 2016.Product Details of 20780-72-7 This article mentions the following:

A highly efficient phospha-aldol reaction for the synthesis of 伪¹-oxindole-伪-hydroxyphosphonates is developed using N-heterocyclic phosphine (NHP)-thiourea as a phosphonylation reagent under catalyst, additive free conditions. This methodol. encompasses a variety of isatin derivatives to provide 伪¹-oxindole- 伪-hydroxyphosphonates up to 99% yield. In the experiment, the researchers used many compounds, for example, 4-Bromoindoline-2,3-dione (cas: 20780-72-7Product Details of 20780-72-7).

4-Bromoindoline-2,3-dione (cas: 20780-72-7) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Product Details of 20780-72-7

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Simple organocatalyst component system for asymmetric hetero Diels-Alder reaction of isatins with enones was written by Parasuraman, Perumalsamy;Begum, Zubeda;Chennapuram, Madhu;Seki, Chigusa;Okuyama, Yuko;Kwon, Eunsang;Uwai, Koji;Tokiwa, Michio;Tokiwa, Suguru;Takeshita, Mitsuhiro;Nakano, Hiroto. And the article was included in RSC Advances in 2020.Computed Properties of C8H4BrNO2 This article mentions the following:

A simple two catalyst component system consisting of primary 尾-amino alcs. as a catalyst and amino acids as a co-catalyst put together worked as an efficient organocatalyst system in hetero Diels-Alder reaction of isatins with enones to afford chiral spirooxindole-tetrahydropyranones I [R¹ = H, Cl, Br; R² = H, Me, Br; R³ = H, Cl; R⁴ = allyl, Pr, iso-Pr, hexyl] in good chem. yields and stereoselectivities (up to 86%, up to 85 : 15 dr., up to 95% ee). In the experiment, the researchers used many compounds, for example, 4-Bromoindoline-2,3-dione (cas: 20780-72-7Computed Properties of C8H4BrNO2).

4-Bromoindoline-2,3-dione (cas: 20780-72-7) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Computed Properties of C8H4BrNO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Highly Enantioselective Synthesis of (R)-3-Alkyl-3-hydroxyindolin-2-ones including Natural Product (R)-Convolutamydine A Catalyzed by a Primary Amine was written by Guo, Jun-Tao;Zhang, Bao-Qiang;Luo, Yuan;Guan, Zhi;He, Yan-Hong. And the article was included in Asian Journal of Organic Chemistry in 2017.HPLC of Formula: 20780-72-7 This article mentions the following:

An efficient strategy for constructing (R)-3-alkyl-3-hydroxyindolin-2-one derivatives I (R¹ = H, 4-Cl, 5-Br, etc.; R² = H, CH₃, Bn) catalyzed by a structurally simple and easily prepared primary amine catalyst under mild conditions has been developed. Various isatins and ketones were tolerated, and the desired products were obtained in up to 99 % yield and up to 99 % ee. The biol. active natural product (R)-convolutamydine A was synthesized in 96 % yield and 95 % ee. In the experiment, the researchers used many compounds, for example, 4-Bromoindoline-2,3-dione (cas: 20780-72-7HPLC of Formula: 20780-72-7).

4-Bromoindoline-2,3-dione (cas: 20780-72-7) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). HPLC of Formula: 20780-72-7

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Organocatalytic Aza-Michael/Michael Cyclization Cascade Reaction: Enantioselective Synthesis of Spiro-oxindole Piperidin-2-one Derivatives was written by Tang, Qing-Gang;Cai, Sen-Lin;Wang, Chuan-Chuan;Lin, Guo-Qiang;Sun, Xing-Wen. And the article was included in Organic Letters in 2020.Quality Control of 4-Bromoindoline-2,3-dione This article mentions the following:

A simple, direct and highly enantioselective synthesis of spiro-oxindole piperidin-2-one derivatives was achieved through an aza-Michael/Michael cyclization cascade sequence using a squaramide catalyst. The desired products were obtained in excellent yields (up to 99%) and good to high stereoselectivities (up to >20:1 dr and up to 99% ee) under mild conditions. In the experiment, the researchers used many compounds, for example, 4-Bromoindoline-2,3-dione (cas: 20780-72-7Quality Control of 4-Bromoindoline-2,3-dione).

4-Bromoindoline-2,3-dione (cas: 20780-72-7) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Quality Control of 4-Bromoindoline-2,3-dione

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Switchable Access to 3-Carboxylate-4-quinolones and 1-Vinyl-3-carboxylate-4-quinolones via Oxidative Cyclization of Isatins and Alkynes was written by Jiang, Shi-Fen;Xu, Cheng;Zhou, Zhi-Wen;Zhang, Qin;Wen, Xiao-Hui;Jia, Feng-Cheng;Wu, An-Xin. And the article was included in Organic Letters in 2018.Formula: C8H4BrNO2 This article mentions the following:

Isatins underwent base-dependent oxidative cyclization or tandem oxidative cyclization and diastereoselective addition reactions with arylalkynoates such as PhC顚咰CO₂Me mediated by t-BuO₂H in DMSO to yield quinolinones such as I (with Cs₂CO₃ as base) or oxoquinolinylpropenoates such as II (with K₃PO₄ as base). In the experiment, the researchers used many compounds, for example, 4-Bromoindoline-2,3-dione (cas: 20780-72-7Formula: C8H4BrNO2).

4-Bromoindoline-2,3-dione (cas: 20780-72-7) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Formula: C8H4BrNO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Total Synthesis of (卤)-Aspergilline A was written by Nakhla, Mina C.;Wood, John L.. And the article was included in Journal of the American Chemical Society in 2017.Product Details of 20780-72-7 This article mentions the following:

The total synthesis of (卤)-aspergilline A (I) is described. Key features of the synthesis include pyrrolinone formation via reaction of an intermediate propargyl amine with a Me malonyl chloride derived ammonium enolate and a formal [3+2] cycloaddition between an imidate and cyclopropenone. In the experiment, the researchers used many compounds, for example, 4-Bromoindoline-2,3-dione (cas: 20780-72-7Product Details of 20780-72-7).

4-Bromoindoline-2,3-dione (cas: 20780-72-7) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Product Details of 20780-72-7

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Iodine-Catalyzed Aerobic Oxidation of Spirovinylcyclopropyl Oxindoles to Form Spiro-1,2-dioxolanes Diastereoselectively was written by Xiong, Cheng;Cheng, Kunpeng;Wang, Jiahua;Yang, Fulai;Lu, Jinrong;Zhou, Qingfa. And the article was included in Journal of Organic Chemistry in 2020.Application of 20780-72-7 This article mentions the following:

A novel method of iodine-catalyzed aerobic oxidation with spirovinylcyclopropyl oxindoles under mild conditions has been described. A series of spiro-1,2-dioxolanes were prepared in good to excellent yields and considerable diastereoselectivities. The new approach is operationally simple, scalable, and tolerant of various functional groups. In the experiment, the researchers used many compounds, for example, 4-Bromoindoline-2,3-dione (cas: 20780-72-7Application of 20780-72-7).

4-Bromoindoline-2,3-dione (cas: 20780-72-7) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Application of 20780-72-7

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Catalyst-free synthesis of α¹-oxindole-α-hydroxyphosphonates via phospha-aldol reaction of isatins employing N-heterocyclic phosphine (NHP)-thiourea was written by Molleti, Nagaraju;Yong Kang, Jun. And the article was included in Organic & Biomolecular Chemistry in 2016.Product Details of 20780-72-7 This article mentions the following:

A highly efficient phospha-aldol reaction for the synthesis of α¹-oxindole-α-hydroxyphosphonates is developed using N-heterocyclic phosphine (NHP)-thiourea as a phosphonylation reagent under catalyst, additive free conditions. This methodol. encompasses a variety of isatin derivatives to provide α¹-oxindole- α-hydroxyphosphonates up to 99% yield. In the experiment, the researchers used many compounds, for example, 4-Bromoindoline-2,3-dione (cas: 20780-72-7Product Details of 20780-72-7).

4-Bromoindoline-2,3-dione (cas: 20780-72-7) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Product Details of 20780-72-7

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Simple organocatalyst component system for asymmetric hetero Diels-Alder reaction of isatins with enones was written by Parasuraman, Perumalsamy;Begum, Zubeda;Chennapuram, Madhu;Seki, Chigusa;Okuyama, Yuko;Kwon, Eunsang;Uwai, Koji;Tokiwa, Michio;Tokiwa, Suguru;Takeshita, Mitsuhiro;Nakano, Hiroto. And the article was included in RSC Advances in 2020.Computed Properties of C8H4BrNO2 This article mentions the following:

A simple two catalyst component system consisting of primary β-amino alcs. as a catalyst and amino acids as a co-catalyst put together worked as an efficient organocatalyst system in hetero Diels-Alder reaction of isatins with enones to afford chiral spirooxindole-tetrahydropyranones I [R¹ = H, Cl, Br; R² = H, Me, Br; R³ = H, Cl; R⁴ = allyl, Pr, iso-Pr, hexyl] in good chem. yields and stereoselectivities (up to 86%, up to 85 : 15 dr., up to 95% ee). In the experiment, the researchers used many compounds, for example, 4-Bromoindoline-2,3-dione (cas: 20780-72-7Computed Properties of C8H4BrNO2).

4-Bromoindoline-2,3-dione (cas: 20780-72-7) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Computed Properties of C8H4BrNO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles