Tag: 227.6889

Li, Qiuyu et al. published their research in Organic Letters in 2022 | CAS: 23746-76-1

5-Chloro-2-phenyl-1H-indole (cas: 23746-76-1) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.COA of Formula: C14H10ClN

Palladium-Catalyzed Asymmetric Dearomative Carbonylation of Indoles was written by Li, Qiuyu;Zhang, Yunchu;Zeng, Yuye;Fan, Yujing;Lin, Aijun;Yao, Hequan. And the article was included in Organic Letters in 2022.COA of Formula: C14H10ClN This article mentions the following:

Herein, authors disclose a strategy for the asym. dearomatization of N-arylacyl indoles via a palladium-catalyzed tandem Heck/carbonylation, leading to an array of indoline-3-carboxylates bearing vicinal C2-aza-quaternary and C3 tertiary stereocenters in high yields and excellent enantio- and diastereoselectivities. This study is an important advance in the field of asym. carbonylation and enantioselective dearomatization reactions. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-phenyl-1H-indole (cas: 23746-76-1COA of Formula: C14H10ClN).

5-Chloro-2-phenyl-1H-indole (cas: 23746-76-1) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.COA of Formula: C14H10ClN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Girisha, M. et al. published their research in Indian Journal of Heterocyclic Chemistry in 2008 | CAS: 23746-76-1

5-Chloro-2-phenyl-1H-indole (cas: 23746-76-1) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Synthetic Route of C14H10ClN

Synthesis and biological activities of indole-3-propionic acids was written by Girisha, M.;Badiger, Jaishree;Purohit, M. G.;Thippeswamy, B. S.;Patil, B. M.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2008.Synthetic Route of C14H10ClN This article mentions the following:

Treatment of 2,5-substituted indoles with acrylic acid in presence of acetic acid and acetic anhydride yielded the desired 2,5-substituted indole-3-propionic acids. The structures of compounds were confirmed by IR, NMR and mass spectral data. The newly synthesized compounds were screened for their antiinflammatory activity and analgesic activity. All the compounds of this series showed promising antiinflammatory and analgesic activity. The most active compound of this series was 2-ethoxycarbonyl-5-methylindole-3-propionic acid. It was most potent which showed higher percent of inhibition of edema and analgesia. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-phenyl-1H-indole (cas: 23746-76-1Synthetic Route of C14H10ClN).

5-Chloro-2-phenyl-1H-indole (cas: 23746-76-1) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Synthetic Route of C14H10ClN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Girisha, M. et al. published their research in Indian Journal of Heterocyclic Chemistry in 2008 | CAS: 23746-76-1

5-Chloro-2-phenyl-1H-indole (cas: 23746-76-1) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Synthetic Route of C14H10ClN

Synthesis and biological activities of indole-3-propionic acids was written by Girisha, M.;Badiger, Jaishree;Purohit, M. G.;Thippeswamy, B. S.;Patil, B. M.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2008.Synthetic Route of C14H10ClN This article mentions the following:

Treatment of 2,5-substituted indoles with acrylic acid in presence of acetic acid and acetic anhydride yielded the desired 2,5-substituted indole-3-propionic acids. The structures of compounds were confirmed by IR, NMR and mass spectral data. The newly synthesized compounds were screened for their antiinflammatory activity and analgesic activity. All the compounds of this series showed promising antiinflammatory and analgesic activity. The most active compound of this series was 2-ethoxycarbonyl-5-methylindole-3-propionic acid. It was most potent which showed higher percent of inhibition of edema and analgesia. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-phenyl-1H-indole (cas: 23746-76-1Synthetic Route of C14H10ClN).

5-Chloro-2-phenyl-1H-indole (cas: 23746-76-1) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Synthetic Route of C14H10ClN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles