With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23077-43-2,5-Fluoro-1H-indole-3-carboxylic acid,as a common compound, the synthetic route is as follows.
5-fluoro-1 H-indole-3-carboxylic acid (450 mg),tert-butyl piperazine-1-carboxylate (466 mg),EDC (630 mg),HOBt (446 mg) and triethylamine (0.46 mL)Was dissolved in dichloromethane (25 mL)And the mixture was stirred at room temperature for 18 hours. Water was added to the reaction solution,It was extracted with dichloromethane and washed with saturated brine.The organic layer was dried over sodium sulfate,By distilling off the solvent under reduced pressure,tert-butyl 4- (5-fluoro-1 H-indole-3-carbonyl)Piperazine-1-carboxylate as a crude product.
The synthetic route of 23077-43-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY; YANAGISAWA, KATSUHIKO; KAWAI, AKIYOSHI; (139 pag.)JP2017/171619; (2017); A;,
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