Tag: 233.22

Reaction of phthalimidoalkyl radicals with π-deficient olefins was written by Totoki, Shintaro;Tada, Masaru. And the article was included in Rikogaku Kenkyusho Hokoku, Waseda Daigaku in 1987.HPLC of Formula: 3130-75-4 This article mentions the following:

ω-Phthalimidoalkanoic acids (I, R = H, Me; n = 0-2) give ω-phthalimidoalkyl radicals on Ag ion-mediated oxidation with dioxopersulfate. The radicals thus formed add to electron-deficient olefins such as crotononitrile and Me crotonate to afford ω-phthalimidoalkanenitrile (II, R¹ = CN) and ω-phthalimidoalkanoate (II, R¹ = CO₂Me). In the experiment, the researchers used many compounds, for example, 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4HPLC of Formula: 3130-75-4).

4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.HPLC of Formula: 3130-75-4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

ω-Phthalimidoalkyl Aryl Ureas as Potent and Selective Inhibitors of Cholesterol Esterase was written by Dato, Florian M.;Sheikh, Miriam;Uhl, Rocky Z.;Schueller, Alexandra W.;Steinkrueger, Michaela;Koch, Peter;Neudoerfl, Joerg-Martin;Guetschow, Michael;Goldfuss, Bernd;Pietsch, Markus. And the article was included in ChemMedChem in 2018.Product Details of 3130-75-4 This article mentions the following:

Cholesterol esterase (CEase), a serine hydrolase thought to be involved in atherogenesis and thus coronary heart disease, is considered as a target for inhibitor development. We investigated recombinant human and murine CEases with a new fluorometric assay in a structure-activity relationship study of a small library of ω-phthalimidoalkyl aryl ureas. The urea motif with an attached 3,5-bis(trifluoromethyl)phenyl group and the aromatic character of the ω-phthalimide residue were most important for inhibitory activity. In addition, an alkyl chain composed of three or four methylene groups, connecting the urea and phthalimide moieties, was found to be an optimal spacer for inhibitors. The so-optimized compounds 2 [1-(3,5-bis(trifluoromethyl)phenyl)-3-(3-(1,3-dioxoisoindolin-2-yl)propyl)urea] and 21 [1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-(1,3-dioxoisoindolin-2-yl)butyl)urea] exhibited dissociation constants (K_i) of 1-19 μM on the two CEases and showed either a competitive (2 on the human enzyme and 21 on the murine enzyme) or a noncompetitive mode of inhibition. Two related human serine hydrolases – monoacylglycerol lipase (MAGL)and fatty acid amide hydrolase (FAAH) – were inhibited by ω-phthalimidoalkyl aryl ureas to a lesser extent. In the experiment, the researchers used many compounds, for example, 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4Product Details of 3130-75-4).

4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Product Details of 3130-75-4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Reaction of phthalimidoalkyl radicals with π-deficient olefins was written by Totoki, Shintaro;Tada, Masaru. And the article was included in Rikogaku Kenkyusho Hokoku, Waseda Daigaku in 1987.HPLC of Formula: 3130-75-4 This article mentions the following:

ω-Phthalimidoalkanoic acids (I, R = H, Me; n = 0-2) give ω-phthalimidoalkyl radicals on Ag ion-mediated oxidation with dioxopersulfate. The radicals thus formed add to electron-deficient olefins such as crotononitrile and Me crotonate to afford ω-phthalimidoalkanenitrile (II, R¹ = CN) and ω-phthalimidoalkanoate (II, R¹ = CO₂Me). In the experiment, the researchers used many compounds, for example, 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4HPLC of Formula: 3130-75-4).

4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.HPLC of Formula: 3130-75-4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

ω-Phthalimidoalkyl Aryl Ureas as Potent and Selective Inhibitors of Cholesterol Esterase was written by Dato, Florian M.;Sheikh, Miriam;Uhl, Rocky Z.;Schueller, Alexandra W.;Steinkrueger, Michaela;Koch, Peter;Neudoerfl, Joerg-Martin;Guetschow, Michael;Goldfuss, Bernd;Pietsch, Markus. And the article was included in ChemMedChem in 2018.Product Details of 3130-75-4 This article mentions the following:

Cholesterol esterase (CEase), a serine hydrolase thought to be involved in atherogenesis and thus coronary heart disease, is considered as a target for inhibitor development. We investigated recombinant human and murine CEases with a new fluorometric assay in a structure-activity relationship study of a small library of ω-phthalimidoalkyl aryl ureas. The urea motif with an attached 3,5-bis(trifluoromethyl)phenyl group and the aromatic character of the ω-phthalimide residue were most important for inhibitory activity. In addition, an alkyl chain composed of three or four methylene groups, connecting the urea and phthalimide moieties, was found to be an optimal spacer for inhibitors. The so-optimized compounds 2 [1-(3,5-bis(trifluoromethyl)phenyl)-3-(3-(1,3-dioxoisoindolin-2-yl)propyl)urea] and 21 [1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-(1,3-dioxoisoindolin-2-yl)butyl)urea] exhibited dissociation constants (K_i) of 1-19 μM on the two CEases and showed either a competitive (2 on the human enzyme and 21 on the murine enzyme) or a noncompetitive mode of inhibition. Two related human serine hydrolases – monoacylglycerol lipase (MAGL)and fatty acid amide hydrolase (FAAH) – were inhibited by ω-phthalimidoalkyl aryl ureas to a lesser extent. In the experiment, the researchers used many compounds, for example, 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4Product Details of 3130-75-4).

4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Product Details of 3130-75-4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Efficient synthesis and resolution of pyrrolizidines was written by de Figueiredo, Renata Marcia;Froehlich, Roland;Christmann, Mathias. And the article was included in Angewandte Chemie, International Edition in 2007.Name: 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid This article mentions the following:

In only two steps the com. available maleimide I is converted into the key pyrrolizidine carboxylic acid unit II of the telomerase inhibitor UCS1025A. A kinetic resolution through an enantioselective oxa-Michael lactonization and trituration of the resulting scalemic mixture allow for a virtually quant. separation of a racemate into the enantiomers. In the experiment, the researchers used many compounds, for example, 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4Name: 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid).

4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Name: 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Enantioselective Radical Carbocyanation of 1,3-Dienes via Photocatalytic Generation of Allylcopper Complexes was written by Lu, Fu-Dong;Lu, Liang-Qiu;He, Gui-Feng;Bai, Jun-Chuan;Xiao, Wen-Jing. And the article was included in Journal of the American Chemical Society in 2021.SDS of cas: 1538551-54-0 This article mentions the following:

1,3-Dienes are readily available feedstocks that are widely used in the laboratory and industry. However, the potential of converting 1,3-dienes into value-added products, especially chiral products, has not yet been fully exploited. By synergetic photoredox/copper catalysis, we achieve the first visible-light-induced, enantioselective carbocyanation of 1,3-dienes by using carboxylic acid derivatives and trimethylsilyl cyanide. Under mild and neutral conditions, a diverse range of chiral allyl cyanides are produced in generally good efficiency and with high enantioselectivity from bench-stable and user-safe chems. Moreover, preliminary results also confirm that this success can be expanded to 1,3-enynes and the four-component carbonylative carbocyanation of 1,3-dienes and 1,3-enynes. In the experiment, the researchers used many compounds, for example, 1,3-Dioxoisoindolin-2-yl butyrate (cas: 1538551-54-0SDS of cas: 1538551-54-0).

1,3-Dioxoisoindolin-2-yl butyrate (cas: 1538551-54-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.SDS of cas: 1538551-54-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Photo electron transfer induced macrocyclization of N-phthaloyl-ω-aminocarboxylic acids was written by Griesbeck, Axel G.;Henz, Andreas;Peters, Karl;Peters, Eva-Maria;von Schnering, Hans Georg. And the article was included in Angewandte Chemie, International Edition in English in 1995.Reference of 3130-75-4 This article mentions the following:

Macrocycles such as azacyclotridecane I (n = 9) can be prepared by irradiating phthaloyl aminocarboxylic acids such as 12-aminododecanoic acid derivative II in acetone/K₂CO₃/H₂O. In the experiment, the researchers used many compounds, for example, 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4Reference of 3130-75-4).

4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Reference of 3130-75-4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Reaction of phthalimidoalkyl radicals with π-deficient olefins was written by Totoki, Shintaro;Tada, Masaru. And the article was included in Rikogaku Kenkyusho Hokoku, Waseda Daigaku in 1987.HPLC of Formula: 3130-75-4 This article mentions the following:

ω-Phthalimidoalkanoic acids (I, R = H, Me; n = 0-2) give ω-phthalimidoalkyl radicals on Ag ion-mediated oxidation with dioxopersulfate. The radicals thus formed add to electron-deficient olefins such as crotononitrile and Me crotonate to afford ω-phthalimidoalkanenitrile (II, R¹ = CN) and ω-phthalimidoalkanoate (II, R¹ = CO₂Me). In the experiment, the researchers used many compounds, for example, 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4HPLC of Formula: 3130-75-4).

4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.HPLC of Formula: 3130-75-4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

ω-Phthalimidoalkyl Aryl Ureas as Potent and Selective Inhibitors of Cholesterol Esterase was written by Dato, Florian M.;Sheikh, Miriam;Uhl, Rocky Z.;Schueller, Alexandra W.;Steinkrueger, Michaela;Koch, Peter;Neudoerfl, Joerg-Martin;Guetschow, Michael;Goldfuss, Bernd;Pietsch, Markus. And the article was included in ChemMedChem in 2018.Product Details of 3130-75-4 This article mentions the following:

Cholesterol esterase (CEase), a serine hydrolase thought to be involved in atherogenesis and thus coronary heart disease, is considered as a target for inhibitor development. We investigated recombinant human and murine CEases with a new fluorometric assay in a structure-activity relationship study of a small library of ω-phthalimidoalkyl aryl ureas. The urea motif with an attached 3,5-bis(trifluoromethyl)phenyl group and the aromatic character of the ω-phthalimide residue were most important for inhibitory activity. In addition, an alkyl chain composed of three or four methylene groups, connecting the urea and phthalimide moieties, was found to be an optimal spacer for inhibitors. The so-optimized compounds 2 [1-(3,5-bis(trifluoromethyl)phenyl)-3-(3-(1,3-dioxoisoindolin-2-yl)propyl)urea] and 21 [1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-(1,3-dioxoisoindolin-2-yl)butyl)urea] exhibited dissociation constants (K_i) of 1-19 μM on the two CEases and showed either a competitive (2 on the human enzyme and 21 on the murine enzyme) or a noncompetitive mode of inhibition. Two related human serine hydrolases – monoacylglycerol lipase (MAGL)and fatty acid amide hydrolase (FAAH) – were inhibited by ω-phthalimidoalkyl aryl ureas to a lesser extent. In the experiment, the researchers used many compounds, for example, 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4Product Details of 3130-75-4).

4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Product Details of 3130-75-4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles