With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.244-63-3,9H-Pyrido[3,4-b]indole,as a common compound, the synthetic route is as follows.
[EXAMPLE 7: Target Compound 12]; [Show Image] Under a nitrogen stream, 9H-pyrido[3,4-b]indole (2.8 g), Target Compound 3 (2.47 g), a copper powder (1.06 g), potassium carbonate (4.6 g), and tetraglyme (8 mL) were allowed to react at 180¡ãC for 8 hours with stirring. After the completion of the reaction, chloroform was added to the reaction mixture. The insoluble matter was filtered off. After the filtrate was concentrated, the resulting precipitate was subjected to suspension washing with methanol and purified by silica-gel column chromatography (an ethyl acetate/methylene chloride mixture –> an ethanol/methylene chloride mixture) to yield Target Compound 12 (1.27 g). DEI-MS: m/z = 617 (M – H)+ DCI-MS: m/z = 619 (M + H)+ This compound had a glass transition temperature of 135¡ãC, a melting point of 221¡ãC, and a vaporization temperature of 499¡ãC. This compound was dissolved in toluene in an amount of 3 percent by weight or more. The difference in energy between the excited triplet state and the ground state of this compound was 2.96 eV.
The synthetic route of 244-63-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Mitsubishi Chemical Corporation; EP1956008; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles