With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.245-08-9,5H-Pyrido[3,2-b]indole,as a common compound, the synthetic route is as follows.,245-08-9
General procedure: To a solution of 8 (100 mg) in dried 1, 2-dimethoxyethane (5 ml), NaH (20 mg, 0.83 mmol) and then 9 (636 mg, 2.27 mmol) were added. The reaction was stirred at rt for 12 h, solvent was removed under reduced pressure and the residue partitioned between H2O (10 ml) and EtOAc (2 ¡Á 30 ml). The pooled organic phase was washed with brine, dried over anhydrous Na2SO4 and the solvent was removed under reduced pressure. The crude product was purified by column chromatography (hexane: EtOAc 4:1).
The synthetic route of 245-08-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Mazu, Tryphon K.; Etukala, Jagan R.; Jacob, Melissa R.; Khan, Shabana I.; Walker, Larry A.; Ablordeppey, Seth Y.; European Journal of Medicinal Chemistry; vol. 46; 6; (2011); p. 2378 – 2385;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles