Tag: 257.6934

Dar’in, Dmitry et al. published their research in Synthesis in 2020 | CAS: 52206-05-0

1-Acetylindoline-5-sulfonyl chloride (cas: 52206-05-0) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.COA of Formula: C10H8ClNO3S

Facile One-Pot Access to 伪-Diazo-尾-ketosulfones from Sulfonyl Chlorides and 伪-Haloketones was written by Dar’in, Dmitry;Kantin, Grigory;Bakulina, Olga;Krasavin, Mikhail. And the article was included in Synthesis in 2020.COA of Formula: C10H8ClNO3S This article mentions the following:

A convenient one-pot approach to the preparation of 伪-diazo-尾-ketosulfones R1SO2C(=N2)C(O)R2 [R1 = Me, cyclohexyl, Ph, etc.; R2 = Me, Ph, 4-FC6H4, etc.] from sulfonyl chlorides was described. It involved the conversion of sulfonyl chloride to sodium sulfinate, alkylation of latter with 伪-haloketones followed by diazo transfer using ‘sulfonyl-azide-free’ (SAFE) protocol in aqueous medium. The simple and expedient method relied on readily available starting materials and provided facile access to a wide variety of valuable diazo reagents for organic synthesis. In the experiment, the researchers used many compounds, for example, 1-Acetylindoline-5-sulfonyl chloride (cas: 52206-05-0COA of Formula: C10H8ClNO3S).

1-Acetylindoline-5-sulfonyl chloride (cas: 52206-05-0) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.COA of Formula: C10H8ClNO3S

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zaher, M. R. et al. published their research in Farmaco, Edizione Scientifica in 1986 | CAS: 52206-05-0

1-Acetylindoline-5-sulfonyl chloride (cas: 52206-05-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Reference of 52206-05-0

Synthesis of some 1-acetylindoline-5-sulfonyl amino acid derivatives and studies of their antimicrobial activities was written by Zaher, M. R.;Kora, F. A.;Hussein, M. E.;El-Sayed, R. A.;El-Naggar, A. M.. And the article was included in Farmaco, Edizione Scientifica in 1986.Reference of 52206-05-0 This article mentions the following:

Title amino acid derivatives I (R = amino acid residue or corresponding Me ester or hydrazide, dipeptide Me ester residue) were prepared from 1-acetylindoline-5-sulfonyl chloride and amino acids or esters and optional hydrazinolysis or peptide coupling. Most I (27 compounds) showed antimicrobial activity against a variety of microorganisms. In the experiment, the researchers used many compounds, for example, 1-Acetylindoline-5-sulfonyl chloride (cas: 52206-05-0Reference of 52206-05-0).

1-Acetylindoline-5-sulfonyl chloride (cas: 52206-05-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Reference of 52206-05-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zaher, M. R. et al. published their research in Farmaco, Edizione Scientifica in 1986 | CAS: 52206-05-0

1-Acetylindoline-5-sulfonyl chloride (cas: 52206-05-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Reference of 52206-05-0

Synthesis of some 1-acetylindoline-5-sulfonyl amino acid derivatives and studies of their antimicrobial activities was written by Zaher, M. R.;Kora, F. A.;Hussein, M. E.;El-Sayed, R. A.;El-Naggar, A. M.. And the article was included in Farmaco, Edizione Scientifica in 1986.Reference of 52206-05-0 This article mentions the following:

Title amino acid derivatives I (R = amino acid residue or corresponding Me ester or hydrazide, dipeptide Me ester residue) were prepared from 1-acetylindoline-5-sulfonyl chloride and amino acids or esters and optional hydrazinolysis or peptide coupling. Most I (27 compounds) showed antimicrobial activity against a variety of microorganisms. In the experiment, the researchers used many compounds, for example, 1-Acetylindoline-5-sulfonyl chloride (cas: 52206-05-0Reference of 52206-05-0).

1-Acetylindoline-5-sulfonyl chloride (cas: 52206-05-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Reference of 52206-05-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles