Tag: 282.13

Eastwood, Paul et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2011 | CAS: 1190861-43-8

6-Bromo-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-2-one (cas: 1190861-43-8) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Related Products of 1190861-43-8

Indolin-2-one p38伪 inhibitors III: Bioisosteric amide replacement was written by Eastwood, Paul;Gonzalez, Jacob;Gomez, Elena;Caturla, Francisco;Aguilar, Nuria;Mir, Marta;Aiguade, Josep;Matassa, Victor;Balague, Cristina;Orellana, Adelina;Dominguez, Maria. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Related Products of 1190861-43-8 This article mentions the following:

Crystallog. structural information was used in the design and synthesis of a number of bioisosteric derivatives to replace the amide moiety in a lead series of p38伪 inhibitors which showed general hydrolytic instability in human liver preparations Triazole derivative I was found to have moderate bioavailability in the rat and demonstrated potent in-vivo activity in an acute model of inflammation. In the experiment, the researchers used many compounds, for example, 6-Bromo-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-2-one (cas: 1190861-43-8Related Products of 1190861-43-8).

6-Bromo-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-2-one (cas: 1190861-43-8) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Related Products of 1190861-43-8

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Eastwood, Paul et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2011 | CAS: 1190861-43-8

6-Bromo-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-2-one (cas: 1190861-43-8) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Related Products of 1190861-43-8

Indolin-2-one p38α inhibitors III: Bioisosteric amide replacement was written by Eastwood, Paul;Gonzalez, Jacob;Gomez, Elena;Caturla, Francisco;Aguilar, Nuria;Mir, Marta;Aiguade, Josep;Matassa, Victor;Balague, Cristina;Orellana, Adelina;Dominguez, Maria. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Related Products of 1190861-43-8 This article mentions the following:

Crystallog. structural information was used in the design and synthesis of a number of bioisosteric derivatives to replace the amide moiety in a lead series of p38α inhibitors which showed general hydrolytic instability in human liver preparations Triazole derivative I was found to have moderate bioavailability in the rat and demonstrated potent in-vivo activity in an acute model of inflammation. In the experiment, the researchers used many compounds, for example, 6-Bromo-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-2-one (cas: 1190861-43-8Related Products of 1190861-43-8).

6-Bromo-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-2-one (cas: 1190861-43-8) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Related Products of 1190861-43-8

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Eastwood, Paul et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2011 | CAS: 1190861-43-8

6-Bromo-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-2-one (cas: 1190861-43-8) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Related Products of 1190861-43-8

Indolin-2-one p38α inhibitors III: Bioisosteric amide replacement was written by Eastwood, Paul;Gonzalez, Jacob;Gomez, Elena;Caturla, Francisco;Aguilar, Nuria;Mir, Marta;Aiguade, Josep;Matassa, Victor;Balague, Cristina;Orellana, Adelina;Dominguez, Maria. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Related Products of 1190861-43-8 This article mentions the following:

Crystallog. structural information was used in the design and synthesis of a number of bioisosteric derivatives to replace the amide moiety in a lead series of p38α inhibitors which showed general hydrolytic instability in human liver preparations Triazole derivative I was found to have moderate bioavailability in the rat and demonstrated potent in-vivo activity in an acute model of inflammation. In the experiment, the researchers used many compounds, for example, 6-Bromo-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-2-one (cas: 1190861-43-8Related Products of 1190861-43-8).

6-Bromo-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-2-one (cas: 1190861-43-8) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Related Products of 1190861-43-8

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Eastwood, Paul et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2011 | CAS: 1190861-43-8

6-Bromo-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-2-one (cas: 1190861-43-8) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Related Products of 1190861-43-8

Indolin-2-one p38α inhibitors III: Bioisosteric amide replacement was written by Eastwood, Paul;Gonzalez, Jacob;Gomez, Elena;Caturla, Francisco;Aguilar, Nuria;Mir, Marta;Aiguade, Josep;Matassa, Victor;Balague, Cristina;Orellana, Adelina;Dominguez, Maria. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Related Products of 1190861-43-8 This article mentions the following:

Crystallog. structural information was used in the design and synthesis of a number of bioisosteric derivatives to replace the amide moiety in a lead series of p38α inhibitors which showed general hydrolytic instability in human liver preparations Triazole derivative I was found to have moderate bioavailability in the rat and demonstrated potent in-vivo activity in an acute model of inflammation. In the experiment, the researchers used many compounds, for example, 6-Bromo-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-2-one (cas: 1190861-43-8Related Products of 1190861-43-8).

6-Bromo-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-2-one (cas: 1190861-43-8) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Related Products of 1190861-43-8

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles