Tag: 288385-88-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.288385-88-6,4-Fluoro-5-hydroxy-2-methylindole,as a common compound, the synthetic route is as follows.

4-Chloro-7-benzyloxy-6-methoxy-quinoline (WO2008112407, 1.5 g) was mixed with DMAP (1.5 eq), 2-methyl-4-fluoro-5-hydroxyindole (WO0047212) (1 eq) in dioxane (20 ml). The reaction was refluxed for three days and diluted with EtOAc, water and extracted with EtOAc three times. The combined organic layer was washed with water, brine and dried. The solution was evaporated and purified with silica gel column to give 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-benzyloxyquinoline (600 mg).

As the paragraph descriping shows that 288385-88-6 is playing an increasingly important role.

Reference£º
Patent; CHEN, GUOQING PAUL; US2010/48599; (2010); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

288385-88-6, 4-Fluoro-5-hydroxy-2-methylindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-amino-6-chloro-pyrimidine-5-carbaldehyde Compound Ia (1.4 g), 4-fluoro-2- methyl-lH-indol-5-ol Compound Ib (1.3 g), Cs2CO3 (5.8 g) and DMSO (10 mL) were added to a flask.The mixture was stirred at rt for 2 hrs, then poured into water and extracted with EtOAc. The organic layer was separated, dried with MgSO4, then concentrated and the residue was purified by flash chromatography (CH2Cl2:MeOH/9.5:0.5) to afford 4- amino-6-(4-fluoro-2-methyl- 1 H-indol-5 -yloxy)-pyrimidine-5 -carbaldehyde Compound Ic (2.2 g, 94%) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) delta 11.30 (s, IH),10.40 (s, IH), 8.55 (s, IH), 8.40 (s, IH), 8.10 (s, IH), 7.05 (d, IH), 6.85 (t, IH), 6.20 (s, IH), 2.40 (s, 3H). MS (ESI) m/z: 285 (M+H+).

As the paragraph descriping shows that 288385-88-6 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2007/109783; (2007); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles