Tag: 309.316

Reductive Decarboxylative Alkynylation of N-Hydroxyphthalimide Esters with Bromoalkynes was written by Huang, Liangbin;Olivares, Astrid M.;Weix, Daniel J.. And the article was included in Angewandte Chemie, International Edition in 2017.Category: indole-building-block This article mentions the following:

A new method for the synthesis of terminal and internal alkynes from the Ni-catalyzed decarboxylative coupling of N-hydroxyphthalimide esters and bromoalkynes is presented. This reductive cross-electrophile coupling is the 1st to use a C(sp)-X electrophile, and appears to proceed via an alkynylnickel intermediate. The internal alkyne products were obtained in yields of 41-95% without the need for a photocatalyst, light, or a strong oxidant. The reaction displays a broad scope of carboxylic acid and alkyne coupling partners, and can tolerate an array of functional groups, including carbamate NH, halogen, nitrile, olefin, ketone, and ester moieties. Mechanistic studies suggest that this process does not involve an alkynylmanganese reagent and instead proceeds through Ni-mediated bond formation. In the experiment, the researchers used many compounds, for example, 1,3-Dioxoisoindolin-2-yl 4-phenylbutanoate (cas: 1841512-58-0Category: indole-building-block).

1,3-Dioxoisoindolin-2-yl 4-phenylbutanoate (cas: 1841512-58-0) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Photoinduced copper-catalyzed dual decarboxylative coupling of 伪,尾-unsaturated carboxylic acids with redox-active esters was written by Lu, Xiao-Yu;Gao, Ang;Liu, Qi-Le;Xia, Ze-Jie. And the article was included in Tetrahedron in 2021.Related Products of 1841512-58-0 This article mentions the following:

The first photoinduced copper-catalyzed dual decarboxylative cross-coupling of 伪,伪-unsaturated carboxylic acids ArCH=CHC(O)OH (Ar = Ph, 3-fluorophenyl, 3,4-dimethoxyphenyl, furan-2-yl, etc.) and redox-active esters I (R = t-bu, Ph, cyclohexyl, oxan-4-yl, 3-phenylpropyl, etc.)has been developed. This reaction enabled C(sp²)-C(sp³) bond formation, which afforded a variety of synthetically valuable alkene derivs ArCH=CHR. Many 伪,伪-unsaturated carboxylic acids and redox-active ester derivatives I were tolerant to this reaction. The reaction also tolerated many common functional groups. In the experiment, the researchers used many compounds, for example, 1,3-Dioxoisoindolin-2-yl 4-phenylbutanoate (cas: 1841512-58-0Related Products of 1841512-58-0).

1,3-Dioxoisoindolin-2-yl 4-phenylbutanoate (cas: 1841512-58-0) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Related Products of 1841512-58-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Reductive Decarboxylative Alkynylation of N-Hydroxyphthalimide Esters with Bromoalkynes was written by Huang, Liangbin;Olivares, Astrid M.;Weix, Daniel J.. And the article was included in Angewandte Chemie, International Edition in 2017.Category: indole-building-block This article mentions the following:

A new method for the synthesis of terminal and internal alkynes from the Ni-catalyzed decarboxylative coupling of N-hydroxyphthalimide esters and bromoalkynes is presented. This reductive cross-electrophile coupling is the 1st to use a C(sp)-X electrophile, and appears to proceed via an alkynylnickel intermediate. The internal alkyne products were obtained in yields of 41-95% without the need for a photocatalyst, light, or a strong oxidant. The reaction displays a broad scope of carboxylic acid and alkyne coupling partners, and can tolerate an array of functional groups, including carbamate NH, halogen, nitrile, olefin, ketone, and ester moieties. Mechanistic studies suggest that this process does not involve an alkynylmanganese reagent and instead proceeds through Ni-mediated bond formation. In the experiment, the researchers used many compounds, for example, 1,3-Dioxoisoindolin-2-yl 4-phenylbutanoate (cas: 1841512-58-0Category: indole-building-block).

1,3-Dioxoisoindolin-2-yl 4-phenylbutanoate (cas: 1841512-58-0) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Photoinduced copper-catalyzed dual decarboxylative coupling of α,β-unsaturated carboxylic acids with redox-active esters was written by Lu, Xiao-Yu;Gao, Ang;Liu, Qi-Le;Xia, Ze-Jie. And the article was included in Tetrahedron in 2021.Related Products of 1841512-58-0 This article mentions the following:

The first photoinduced copper-catalyzed dual decarboxylative cross-coupling of α,α-unsaturated carboxylic acids ArCH=CHC(O)OH (Ar = Ph, 3-fluorophenyl, 3,4-dimethoxyphenyl, furan-2-yl, etc.) and redox-active esters I (R = t-bu, Ph, cyclohexyl, oxan-4-yl, 3-phenylpropyl, etc.)has been developed. This reaction enabled C(sp²)-C(sp³) bond formation, which afforded a variety of synthetically valuable alkene derivs ArCH=CHR. Many α,α-unsaturated carboxylic acids and redox-active ester derivatives I were tolerant to this reaction. The reaction also tolerated many common functional groups. In the experiment, the researchers used many compounds, for example, 1,3-Dioxoisoindolin-2-yl 4-phenylbutanoate (cas: 1841512-58-0Related Products of 1841512-58-0).

1,3-Dioxoisoindolin-2-yl 4-phenylbutanoate (cas: 1841512-58-0) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Related Products of 1841512-58-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Photoinduced copper-catalyzed dual decarboxylative coupling of α,β-unsaturated carboxylic acids with redox-active esters was written by Lu, Xiao-Yu;Gao, Ang;Liu, Qi-Le;Xia, Ze-Jie. And the article was included in Tetrahedron in 2021.Related Products of 1841512-58-0 This article mentions the following:

The first photoinduced copper-catalyzed dual decarboxylative cross-coupling of α,α-unsaturated carboxylic acids ArCH=CHC(O)OH (Ar = Ph, 3-fluorophenyl, 3,4-dimethoxyphenyl, furan-2-yl, etc.) and redox-active esters I (R = t-bu, Ph, cyclohexyl, oxan-4-yl, 3-phenylpropyl, etc.)has been developed. This reaction enabled C(sp²)-C(sp³) bond formation, which afforded a variety of synthetically valuable alkene derivs ArCH=CHR. Many α,α-unsaturated carboxylic acids and redox-active ester derivatives I were tolerant to this reaction. The reaction also tolerated many common functional groups. In the experiment, the researchers used many compounds, for example, 1,3-Dioxoisoindolin-2-yl 4-phenylbutanoate (cas: 1841512-58-0Related Products of 1841512-58-0).

1,3-Dioxoisoindolin-2-yl 4-phenylbutanoate (cas: 1841512-58-0) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Related Products of 1841512-58-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles