With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3484-18-2,2-Ethyl-1H-indole,as a common compound, the synthetic route is as follows.
2-Ethylindole (0.5 g, 3.4 mmol) dissolved in DMF (2 mL) was added to a cold (0¡ã C.) premixed (30 minutes) mixture of DMF (1.15 mL) and phosphorous oxychloride(0.64 g, 4.16 mmol). After addition of 2-ethylindole, the mixture was heated to 40¡ã C. for 1 h, water (5 mL) was added and the pH adjusted to 5 by means of 1 N sodium hydroxide.The mixture was subsequently extracted with diethyl ether, the organic phase isolated, dried with MgSO4 and evaporated to dryness affording 2-ethylindole-3-carbaldehyde (300 mg). HPLC-MS (Method C): m/z:174 (M+1); Rt.=2.47 min.
The synthetic route of 3484-18-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Kaarsholm, Niels Christian; Madsen, Peter; Schlein, Morten; Olsen, Helle Birk; Havelund, Svend; Steensgaard, Dorte Bjerre; Ludvigsen, Svend; Jakobsen, Palle; Petersen, Anders Klarskov; Schluckebier, Gerd; US2005/65066; (2005); A1;,
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