Tag: 400-500

Synthesis and antiviral activity of some 5′-N-phthaloyl-3′-azido-2′,3′-dideoxythymidine analogues was written by Balzarini, Jan;De Clercq, Erik;Kaminska, Beata;Orzeszko, Andrzej. And the article was included in Antiviral Chemistry & Chemotherapy in 2003.Reference of 24407-32-7 This article mentions the following:

A variety of substituted 5′-N-phthaloyl-3′-azido-2′,3′-dideoxythymidine derivatives has been evaluated for their activity against HIV-1, HIV-2 and Moloney murine sarcoma virus (MSV) in cell culture. Most of the 3′-azido-2′,3′-dideoxythymidine (AZT, zidovudine) derivatives showed antiviral activity in the lower micromolar concentration range and there was a close correlation between their anti-HIV and anti-MSV activity (r=0.99). The adamantyl phthaloyl derivative was active at submicromolar concentrations None of the compounds showed marked cytostatic activity. They did not inhibit recombinant HIV-1 reverse transcriptase. All compounds were inactive against HIV in thymidine kinase-deficient cells, pointing to the compounds’ requirement to release free AZT to afford antiviral efficacy. In the experiment, the researchers used many compounds, for example, 4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7Reference of 24407-32-7).

4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Reference of 24407-32-7

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Catalysts for silylations with 1,1,1,3,3,3-hexamethyldisilazane was written by Bruynes, Cornelis A.;Jurriens, Theodorus K.. And the article was included in Journal of Organic Chemistry in 1982.Synthetic Route of C8HBr4NO2 This article mentions the following:

Saccharin, Na saccharin, 4-MeC₆H₄SO₂NHP(O)(OC₆H₄NO₂-4)₂, [PhOP(O)]₂NH, Cl₃CCONHP(O)(OC₆H₄NO₂-4)₂, etc. are effective catalysts for silylation with Me₃SiNHSiMe₃. Thus, treating BzOH with Me₃SiNHSiMe₃ in the presence of saccharin gave 92% BzOSiMe₃. In the experiment, the researchers used many compounds, for example, 4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7Synthetic Route of C8HBr4NO2).

4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Synthetic Route of C8HBr4NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthesis of new fireproofing agents for fibers. 1 was written by Sumi, Koichi. And the article was included in Osaka-furitsu Sen’i Gijutsu Kenkyusho Kenkyu Hokoku in 1978.Electric Literature of C8HBr4NO2 This article mentions the following:

2,4-Bis(tetrahalophthalimido)-6-chloro-s-triazines I, where R is Cl or Br, were prepared and were useful as fireproofing agents for textiles. For example, 1.78 mol formamide [75-12-7] was treated with 0.07 mol tetrachlorophthalic anhydride [117-08-8], 0.035 mol of the resulting tetrachlorophthalimide [1571-13-7] was treated with 0.035 mol KOH, and 0.0334 mol of the K salt [59653-19-9] was treated with 0.0167 mol. cyanuric chloride [108-77-0] to give I (R = Cl) [73341-50-1]. In the experiment, the researchers used many compounds, for example, 4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7Electric Literature of C8HBr4NO2).

4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Electric Literature of C8HBr4NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Enantioselective Allylic Amination of Morita-Baylis-Hillman Carbonates Catalysed by Modified Cinchona Alkaloids was written by Zhang, Shan-Jun;Cui, Hai-Lei;Jiang, Kun;Li, Rui;Ding, Zhen-Yu;Chen, Ying-Chun. And the article was included in European Journal of Organic Chemistry in 2009.Computed Properties of C8HBr4NO2 This article mentions the following:

An efficient procedure for the asym. allylic amination of Morita-Baylis-Hillman carbonates I (R = Ph, 2-ClC₆H₄, 3-MeC₆H₄, 1-naphthyl, 2-thienyl, etc.) with cyclic imides II (phthalimide, tetrachlorophthalimide, tetrabromophthalimide, cis-hexahydrophthalimide, 1,8-naphthalimide) catalyzed by com. available cinchona alkaloids is reported. It proves to be a facile protocol that affords α-methylene-β-imido esters III with good-to-excellent enantioselectivities (up to 94 % ee) and in high yields (up to 97 %). (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009). In the experiment, the researchers used many compounds, for example, 4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7Computed Properties of C8HBr4NO2).

4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Computed Properties of C8HBr4NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chemical synthesis and in silico molecular modeling of novel pyrrolyl benzohydrazide derivatives: Their biological evaluation against enoyl ACP reductase (InhA) and Mycobacterium tuberculosis was written by Joshi, Shrinivas D.;More, Uttam A.;Dixit, Sheshagiri R.;Balmi, Sunil V.;Kulkarni, Basavaraj G.;Ullagaddi, Geeta;Lherbet, Christian;Aminabhavi, Tejraj M.. And the article was included in Bioorganic Chemistry in 2017.Safety of 4,5,6,7-Tetrabromoisoindoline-1,3-dione This article mentions the following:

In efforts to develop new antitubercular agents, we report here the synthesis of a series of novel pyrrole hydrazine derivatives The mols. were evaluated against inhibitors of InhA, which is one of the key enzymes involved in type II fatty acid biosynthetic pathway of the mycobacterial cell wall as well as inhibitors of Mycobacterium tuberculosis H37Rv. The binding mode of compounds at the active site of enoyl-ACP reductase was explored using the surflex-docking method. The model suggests one or two H-bonding interactions between the compounds and the InhA enzyme. Some compounds exhibited good activities against InhA in addition to promising activities against M. tuberculosis. In the experiment, the researchers used many compounds, for example, 4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7Safety of 4,5,6,7-Tetrabromoisoindoline-1,3-dione).

4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Safety of 4,5,6,7-Tetrabromoisoindoline-1,3-dione

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Photoinduced regioselective arylation of N-vinyllactams and methylthiazoles by tetrachlorophthalimides was written by Shen, Yong-Miao;Grampp, Guenter;Tao, Fei-Fei;He, Ning-De;Chen, Da-Qing;Ye, Miao. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2013.Electric Literature of C8HBr4NO2 This article mentions the following:

Photoinduced reactions of 4,5,6,7-tetrahalophthalimides (1a-1h) with selected N-vinyllactams (N-vinylpyrrolidinone, N-vinylcaprolactam) and methylthiazoles resp. lead to dehydrohalogenative coupling reactions between the phthalimide and these heterocycles. These mild and metal-free coupling reactions result in regioselective and stereoselective arylation of the heterocycles by the phthalimide, with the Z-isomer as the main products. Reaction mechanism for the photo-reactions is discussed. In the experiment, the researchers used many compounds, for example, 4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7Electric Literature of C8HBr4NO2).

4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Electric Literature of C8HBr4NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

A facile and green synthesis of novel imide and amidic acid derivatives of phenacetin as potential analgesic and anti-pyretic agents was written by Reddy, Yervala D.;Kumar, Padam P.;Devi, Bhoomireddy R.;Dubey, Pramod K.;Kumari, Yalamanchili B.. And the article was included in Letters in Organic Chemistry in 2013.COA of Formula: C8HBr4NO2 This article mentions the following:

Facile and green syntheses of potential analgesic and antipyretic compounds, N-(4-ethoxyphenyl)-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)acetamide derivatives and N-[(4-ethoxyphenylcarbamoyl)methyl]phthalamic acid derivatives have been developed. Two synthetic routes (A and B) have been established for the preparation of the former. In the route-A, 4-ethoxyaniline was reacted with chloroacetyl chloride in a solution of potassium acetate and acetic acid to yield N-(4-ethoxyphenyl)-2-chloroacetamide. The latter was reacted with imide compounds either in triethanolamine as a green solvent or in solid phase in the presence of TEBAC and KI to yield the products. Alternatively, in the route-B, reaction of anhydrides with glycine yielded the (1,3-dioxo-1,3-dihydroisoindol-2-yl)acetic acid derivatives which on reaction with 4-ethoxyaniline either in triethnolamine and DCC as a dehydrating agent or in solid phase in the presence of DCC gave the products. The latter were hydrolyzed in 0.5N ethanolic KOH to afford N-[(4-ethoxyphenylcarbamoyl)methyl]phthalamic acid derivatives In the experiment, the researchers used many compounds, for example, 4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7COA of Formula: C8HBr4NO2).

4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.COA of Formula: C8HBr4NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Tumor necrosis factor-alpha production-regulating activity of phthalimide derivatives in genetically modified murine melanoma cells B78H1 was written by Orzeszko, Andrzej;Lasek, Witold;Switaj, Tomasz;Stoksik, Magdalena;Kaminska, Beata. And the article was included in Farmaco in 2003.Recommanded Product: 4,5,6,7-Tetrabromoisoindoline-1,3-dione This article mentions the following:

The effect of imides, monothioimides, trimellitimides, as well as 5′-deoxy-5′-phthaloylamino-derivatives of azidothymidine on tumor necrosis factor-alpha (TNF-α) production by genetically modified murine B78H1 melanoma cells transduced with the gene for human TNF-α (B78/TNF) was investigated. It was found that N-(adamant-1-yl)monothiophthalimide and N-(adamant-2-yl)-monothiophthalimide showed over 200% enhancing of TNF-α production while some of imides were inhibitors. In the experiment, the researchers used many compounds, for example, 4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7Recommanded Product: 4,5,6,7-Tetrabromoisoindoline-1,3-dione).

4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Recommanded Product: 4,5,6,7-Tetrabromoisoindoline-1,3-dione

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles